Clinical trials: Chronic Ischemic Left Ventricular Dysfunction
Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure
This study evaluates the safety and performance/effectiveness of the C-MIC System, an active implantable medical device designed to treat patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Ischemic and Non-ischemic Cardiomyopathy
- Trial name
- NCT07795359
- Testing
- Subcutaneous cardiac microcurrent treatment
- Volunteers
- 60 people
- Sponsor
- Berlin Heals GmbH
Chronic Ischemic Left Ventricular Dysfunction
Human Embryonic Stem Cell-Derived Cardiomyocyte Therapy for Chronic Ischemic Left Ventricular Dysfunction
This clinical study will utilize a new cell therapy approach (Human embryonic stem cells derived cardiomyocytes or hESC-CMs) to improve survival and cardiac function in patients with chronic left ventricular dysfunction secondary…
- Trial name
- HECTOR (NCT05068674)
- Testing
- Human Embryonic Stem Cell-Derived Cardiomyocyte 50M cells, Human Embryonic Stem Cell-Derived Cardiomyocyte 150 cells, Human Embryonic Stem Cell-Derived Cardiomyocyte 300M cells
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Joseph C. Wu
Chronic Ischemic Left Ventricular Dysfunction, Myocardial Infarction
The Transendocardial Autologous Cells (hMSC) or (hMSC) and (hCSC) in Ischemic Heart Failure Trial.
Before initiating the full randomized study, a Pilot Safety Phase will be performed. In this phase the composition of cells administered via the Biosense Webster MyoStar NOGA Injection Catheter System will be tested.
- Trial name
- TAC-HFT-II (NCT02503280)
- Testing
- Autologous hMSCs, Autologous Human C-Kit CSCs II, Biosense Webster MyoStar NOGA Injection Catheter System
- Where
- United States
- Sponsor
- Joshua M Hare
Chronic Ischemic Left Ventricular Dysfunction, Myocardial Infarction
The TRansendocardial Stem Cell Injection Delivery Effects on Neomyogenesis STudy (The TRIDENT Study)
Thirty (30) patients with chronic ischemic left ventricular dysfunction secondary to MI scheduled to undergo cardiac catheterization will be enrolled in the study.
- Trial name
- Trident (NCT02013674)
- Testing
- Allogeneic hMSCs
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua M Hare
Chronic Ischemic Heart Disease, Left Ventricular Dysfunction
Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)
Coronary artery disease (CAD) is a common disorder that can lead to heart failure. Not all people with CAD are eligible for today's standard treatments.
- Conditions
- Chronic Ischemic Heart Disease, Left Ventricular Dysfunction, Angina, Ischemic Cardiomyopathy
- Trial name
- NCT00824005
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- The University of Texas Health Science Center, Houston
Ischemic Cardiomyopathy, Chronic Ischemic Cardiomyopathy
REgenerative CardiOsphere iNjection to STRengthen dysfUnCTional Hearts
A double blinded and placebo-controlled, dose escalation, single-center safety and preliminary efficacy study of cardiospheres delivered via NOGA MYOSTAR injection catheter in subjects with chronic ischemic cardiomyopathy.
- Trial name
- RECONSTRUCT (NCT01496209)
- Testing
- Endomyocardial injections of allogeneic Human CSps, Endomyocardial injections of vehicle only.
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center