Clinical trials: Chronic Kidney Disease Requiring Chronic Dialysis
Hypercholesterolemia, CKD Stage 5
Evolocumab Plus Ezetimibe in Haemodialized Statin-intolerant Patients With Hypercholesterolemia
Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol, reducing in turn the risk of cardiovascular events.
- Conditions
- Hypercholesterolemia, CKD Stage 5, Chronic Kidney Disease Requiring Chronic Dialysis
- Trial name
- NCT04659525
- Testing
- Evolocumab, Ezetimibe
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Policlinico Casilino ASL RMB
Chronic Kidney Disease Requiring Hemodialysis
Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients
The goal of this study is to learn if a collaborative care intervention of pharmaco-therapy and/or cognitive behavioral therapy (CBT), delivered in a real-world setting, improves symptoms of pain, fatigue and/or depression.
- Trial name
- TACcare 2 0 (NCT06978127)
- Testing
- Technology Assisted Stepped Collaborative Care, Usual Care Arm
- Where
- 2 sites in United States
- Volunteers
- 424 people
- Sponsor
- University of Pittsburgh
End Stage Renal Disease
A Pilot Study To Evaluate The CreatiVasc Hemoaccess Valve System In Patients Requiring Arteriovenous Graft Placement
The ability to selectively control blood flow through an arteriovenous (AV) graft only when it is needed for dialysis may reduce the current repetitive complications such as thrombosis, venous hypertension post-dialysis bleeding…
- Trial name
- NCT01644526
- Testing
- Hemoaccess Valve System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Diaxamed LLC
Chronic Kidney Disease Requiring Chronic Dialysis
Cellulose Triacetate Dialyzer in Hemodiafiltration-online
In post-dilution haemodiafiltration only synthetic membranes have been used to date. The allergy problems described with these membranes require the development of other membranes capable of performing this treatment.
- Trial name
- NCT03105817
- Testing
- Asymmetric cellulose triacetate (ATA™)
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Hospital Universitario Infanta Leonor
Chronic Kidney Diseases, Patient Requiring Heparin Free Dialysis Treatments
Feasibility Study for Heparin-free Hemodialysis With the Dialyzer With Endexo™
This study will assess the safety and efficacy of heparin free hemodialysis (HD) performed with dialyzers with Endexo in adult end-stage renal disease (ESRD) subjects on thrice-weekly in-center HD.
- Trial name
- NCT04511338
- Testing
- Dialyzer with Endexo
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fresenius Medical Care North America
Chronic Kidney Disease Requiring Chronic Dialysis
A Phase 3 Extension Study to Investigate the Long-term Safety, Tolerability and Efficacy of PA21, a Phosphate Binder in Dialysis Patients
This is a Phase 3, randomised, active controlled, multicentre extension study to investigate the long-term safety and efficacy of PA21, a phosphate binder, for control of hyperphosphataemia in dialysis patients.
- Trial name
- NCT01464190
- Testing
- PA21 (2.5 g tablet containing 500 mg iron), Sevelamer carbonate
- Where
- 15 sites in United States, Austria and 13 more
- Volunteers
- 659 people
- Sponsor
- Vifor Pharma
Chronic Kidney Disease Requiring Hemodialysis, End Stage Renal Disease (ESRD)
Early Feasibility Study of the Velocity™ Percutaneous Arterio-Venous Fistula System for Creating Hemodialysis Vascular Access
The Velocity Percutaneous Arterio-Venous System is a minimally invasive method of creating hemodialysis vascular access. The study aims to understand clinical efficacy and initial clinical safety data of the device.
- Trial name
- VENOS-2 (NCT06712251)
- Testing
- Velocity pAVF System
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Venova Medical
Chronic Kidney Disease Requiring Chronic Dialysis
Orthostatic Hypotension and Blood Pressure Variability in Persons Undergoing Hemodialysis
High blood pressure is a risk factor for end-stage renal disease and is common in patients undergoing maintenance hemodialysis. Intradialytic hypotension is associated with an adverse prognosis.
- Trial name
- NCT06348589
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Vrinnevi Hospital
Chronic Kidney Disease Requiring Chronic Dialysis
Intradialytic Pedalling Exercise and Vascular Hemodynamic Parameters Among Prevalent Hemodialysis Population
The purpose of this pilot study is to evaluate 1) the effect of intradialytic pedaling exercise on arterial stiffness and other arterial hemodynamic parameters over 4 months, and 2) the longer-term effect of pedaling on arterial…
- Trial name
- NCT03027778
- Testing
- Exercise
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Anemia, Chronic Kidney Disease Requiring Chronic Dialysis
A Study to Compare Efficacy and Safety of Nanogen's Darbepoetin Alfa With Aranesp® (Amgen) in the Treatment of Anemia in Chronic Kidney Disease Patients on Dialysis (CKD)
This is a double-blind, two-arm, randomized, multicenter to compare the efficacy and safety of NNG-DEPO and Aranesp in CKD on dialysis patients.
- Trial name
- NCT05585645
- Testing
- Stimus (NNG-DEPO)
- Where
- Vietnam
- Volunteers
- 214 people
- Sponsor
- Nanogen Pharmaceutical Biotechnology Joint Stock Company
Chronic Kidney Disease(CKD), Chronic Kidney Disease Requiring Chronic Dialysis
Investigation of the Validity, Reliability, and Responsiveness of BETY-BQ in Chronic Kidney Disease, on Dialysis, and Kidney Transplantation
A review of the literature has shown that Chronic Kidney Disease (CKD) is strongly associated with an increasing degree of psychosocial impact, such as depression and anxiety and a decrease in quality of life.
- Conditions
- Chronic Kidney Disease(CKD), Chronic Kidney Disease Requiring Chronic Dialysis, Kidney Transplantation
- Trial name
- NCT06591702
- Testing
- Questionnaire study
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Hacettepe University
Hyperphosphatemia, End-stage Renal Disease
Trial of a New Formulation of KRX-0502 (Ferric Citrate) in Patients With End-Stage Renal Disease
The objective of this study is to see if KRX-0502 (ferric citrate) is safe and effective as a dietary phosphate binder in controlling and managing serum phosphorus levels in patients with end-stage renal disease (ESRD).
- Conditions
- Hyperphosphatemia, End-stage Renal Disease, Renal Failure Chronic Requiring Hemodialysis
- Trial name
- NCT00967993
- Testing
- ferric citrate
- Where
- 3 sites in Israel
- Volunteers
- 22 people
- Sponsor
- Keryx Biopharmaceuticals
Chronic Kidney Disease Requiring Chronic Dialysis
Reduction of Oxalate and Inflammation by Hemodiafiltration vs. Hemodialysis
The health care burden of CKD is substantial and growing with 10-15% of the population affected in both developed and developing countries.
- Trial name
- NCT02684656
- Testing
- Hemodialysis, Hemodiafiltration
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Kidney Disease (CKD) Stage 5, Kidney Dysfunction Requiring Dialysis (KDRD)
Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
In this pragmatic clinical trial, which will dovetail with Veterans' routine outpatient dialysis clinic visits in six VA medical centers, the investigators will study 252 Veterans with kidney disease who need to start dialysis…
- Conditions
- Chronic Kidney Disease (CKD) Stage 5, Kidney Dysfunction Requiring Dialysis (KDRD), Dialysis Dependency
- Trial name
- INCHVETS (NCT05465044)
- Testing
- Twice-weekly hemodialysis with incremental crossover to thrice-weekly schedule, Thrice-Weekly Hemodialysis
- Where
- 8 sites in United States
- Volunteers
- 252 people
- Sponsor
- VA Office of Research and Development
Chronic Kidney Disease Requiring Chronic Dialysis, Chronic Kidney Diseases
Cardiopulmonary Exercise Testing Parameters' Variability in Hemodialysis Patients.
Chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), is associated with increased risk for cardiovascular events and all-cause mortality.
- Trial name
- NCT05557929
- Where
- Greece
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Chronic Kidney Disease Requiring Chronic Dialysis
Effects of Green Propolis Extract (EPP-AF) on Inflammation in Hemodialysis Patients.
End-stage chronic kidney disease is associated with the condition of chronic inflammation. Patients on hemodialysis are known to be predisposed to several factors that predispose to inflammation: dialysis membranes, central…
- Trial name
- NCT04072341
- Testing
- Propolis Period (Green Propolis 250mg/day), Control Period
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Intradialytic Hypotension, End-Stage Renal Disease Requiring Haemodialysis
Predictive Value of Carotid Ultrasonography for Intradialytic Hypotension
This multicenter, prospective observational study aims to evaluate the predictive value of carotid corrected flow time (FTc) and peak flow velocity variability (PFVV) for hypotension during maintenance hemodialysis.
- Conditions
- Intradialytic Hypotension, End-Stage Renal Disease Requiring Haemodialysis, Uremia; Chronic, Hemodialysis
- Trial name
- CUPID (NCT07033260)
- Testing
- Non-invasive Monitoring
- Where
- China
- Volunteers
- 183 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Renal Failure Chronic Requiring Dialysis, Obstructive Sleep Apnea
Effects of Compression Stockings on Obstructive Sleep Apnea in Patients Under Hemodialysis
To study the effects of compression stockings on sleep apnea in hemodialysis patients with diagnosed obstructive sleep apnea. The rationale of this study consists in the fluid shift theory, which consists in the nocturnal rostral…
- Trial name
- EComStockOSA (NCT02503215)
- Testing
- Compression Stockings
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo
Chronic Kidney Disease, Renal Failure Chronic Requiring Hemodialysis
Specific Enteral Nutrition in Malnourished, Dialysis Patients With Chronic Kidney Disease. Efficacy, Safety, Quality of Life
The objective of this unblinded study is to assess the nutritional effects of a 12 weeks administration of the specific enteral nutrition (SEN) RealDiet®Renal pockets, as well as the impact on the patients' quality of life.
- Conditions
- Chronic Kidney Disease, Renal Failure Chronic Requiring Hemodialysis, Severe Malnutrition, Tolerance
- Trial name
- AL-EN-PHED (NCT01946841)
- Testing
- RealDiet®Renal
- Where
- France
- Sponsor
- Lactalis
Anemia, End Stage Renal Disease
16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis
The purpose of this study is to evaluate the hemoglobin response (efficacy), safety, and tolerability of orally administered AKB-6548 in participants with end stage renal disease undergoing chronic hemodialysis.
- Trial name
- NCT02260193
- Testing
- AKB-6548
- Where
- 16 sites in United States
- Volunteers
- 94 people
- Sponsor
- Akebia Therapeutics