Clinical trials: Chronic Low Back Pain
Pain, Chronic Pain
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in subjects suffering from severe chronic low back pain (LBP) who are taking WHO Step III…
- Conditions
- Pain, Chronic Pain, Low Back Pain, Neuropathic Pain
- Trial name
- NCT00986258
- Testing
- Tapentadol Prolonged Release
- Where
- 27 sites in Belgium, Czechia and 6 more
- Volunteers
- 136 people
- Sponsor
- Grünenthal GmbH
Non-specific Chronic Low Back Pain
An Interactive Gaming-based Intervention for Back Pain
This study aims to compare the outcomes of a traditional, exercise-based rehabilitation intervention for chronic low back pain with the outcomes achieved by combining a traditional intervention with adjunct therapy delivered…
- Trial name
- NCT02503410
- Testing
- Usual care, Interactive gaming
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Spaulding Rehabilitation Hospital
Low Back Pain, Back Pain With Radiation
Evaluating the Role of Neuroinflammation in Low Back Pain
In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain.
- Conditions
- Low Back Pain, Back Pain With Radiation, Back Pain Without Radiation, Back Pain Lower Back Chronic
- Trial name
- IGNITE (NCT03106740)
- Testing
- Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Marco Loggia
Chronic Low Back Pain With a Neuropathic Component
Efficacy and Safety Study of Celecoxib and Pregabalin Compared With Celecoxib Monotherapy, in Patients With Chronic Low Back Pain Having a Neuropathic Component
The purpose of this study is to determine if treatment with celecoxib and pregabalin together would prove to be more effective in relief of pain than treatment with celecoxib alone in people who have chronic low back pain with a…
- Trial name
- NCT01838044
- Testing
- pregabalin and celecoxib
- Where
- 29 sites in Brazil, Chile and 5 more
- Volunteers
- 180 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Low Back Pain
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) Extended Release (ER) in Patients With Moderate to Severe Chronic Low Back Pain
The purpose of this trial is to evaluate the effectiveness (level of pain control) and safety of orally administrated tapentadol (CG5503) Extended Release (ER) (base) at doses of 100-250 mg twice daily in patients with moderate…
- Trial name
- NCT00449176
- Testing
- tapentadol (CG5503) ER, oxycodone CR
- Volunteers
- 981 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Neck Pain, Low Back Pain
Partners for Pain & Wellbeing Equity: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain
The focus of this project is on developing and optimizing community-based programs for the self-management of back or neck pain for individuals from populations that experience health disparities (BP-PEHD).
- Conditions
- Neck Pain, Low Back Pain, Chronic Pain
- Trial name
- NCT05786508
- Testing
- Partners4Pain program, Key to Wellbeing program
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Minnesota
Low Back Pain
A Study of Tanezumab in Adults With Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of multiple doses of tanezumab administered every 8 weeks in treating chronic low back pain.
- Trial name
- NCT00876187
- Testing
- Tanezumab 20 mg IV, Tanezumab 10 mg IV, Tanezumab 5 mg IV
- Where
- 135 sites in United States
- Volunteers
- 1,359 people
- Sponsor
- Pfizer
Chronic Low-back Pain
Brain Effects of Opiate Agonist and Antagonist
This study will look at the short-term effect of morphine on brain response to food.
- Trial name
- NCT04342130
- Testing
- Morphine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Low Back Pain
Targeted Interventions to Prevent Chronic Low Back Pain in High Risk Patients
Low back pain (LBP) is a common problem among US adults. Initial episodes tend to be self-limited ("acute"), but some people can progress to a state of persistent pain.
- Trial name
- TARGET (NCT02647658)
- Testing
- Guideline Based Care plus Psychologically Informed Physical Therapy, Guideline Based Care (GBC)
- Where
- 5 sites in United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pittsburgh
Low Back Pain, Chronic Pain
Optimize Low Back Pain
The objective of this study is to improve health care for patients with chronic LBP and increase the likelihood that patients obtain outcomes that matter most to them.
- Trial name
- OPTIMIZE (NCT03859713)
- Testing
- Physical Therapy, Cognitive Behavioral Therapy, Mindfulness
- Where
- 3 sites in United States
- Volunteers
- 749 people
- Sponsor
- University of Utah
Chronic Low Back Pain
Stimgenics Open-Label, Post Market Study
The purpose of this investigational study is to study the effects of Stimgenics Spinal Cord Stimulation (SGX-SCS) in subjects with chronic, intractable pain of the trunk with lower limb pain, including unilateral or bilateral…
- Trial name
- SGX-SCS-RCT (NCT03606187)
- Testing
- Stimgenics SCS Programming Approach, Standard SCS Programming Approach
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Stimgenics LLC
Chronic Pain, Chronic Low Back Pain
Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain
The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain and functional limitations in subjects with NSCLBP.
- Trial name
- NCT02954432
- Testing
- transcranial Direct Current Stimulation (tDCS), Transcranial Ultrasound (TUS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Spaulding Rehabilitation Hospital
Chronic Low-Back Pain, Refractory Pain
Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)
The objective of this study is to evaluate the efficacy of BurstDR dorsal column stimulation, compared with conventional medical management, in improving pain and back-related physical function in subjects suffering with chronic…
- Conditions
- Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
- Trial name
- NCT04479787
- Testing
- Spinal Cord Stimulation, Conventional Medical Management
- Where
- 30 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Back Pain, Low
Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain
In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain, and whether CBD effects levels of neuroinflammation.
- Trial name
- CBD (NCT03891264)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Back Pain Lower Back Chronic
MOTIVATE: Moving to Improve Outcomes for Older Adults
The overarching goal of this study is to evaluate a tele-based behavioral change intervention for older adults (aged 50 years and older) with chronic low back pain (cLBP) and comorbid depression, and to ultimately assess its…
- Trial name
- NCT03914469
- Testing
- Behavioral Intervention Group
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Aging, Chronic Low-back Pain
Adaptability and Resilience in Aging Adults-2
Chronic low back pain is a major health concern among older adults and is associated with increased economic, functional, and psychological burden.
- Trial name
- ARIAA-2 (NCT04068922)
- Testing
- Resilience Intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Florida
Back Pain
Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain
The primary objective of this randomized controlled trial is to evaluate the safety and efficacy of the TransDiscal System (TDS) in treating discogenic pain of the lumbar spine using a modified disc biacuplasty procedure.
- Trial name
- COLD (NCT01263054)
- Testing
- TransDiscal System, Medical Management
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Halyard Health
Back Pain Lower Back Chronic
An Open Label Extension Study of Duloxetine (LY248686) in Participants With Chronic Low Back Pain
The purpose of the study is to assess the long term safety of duloxetine in participants with Chronic Low Back Pain (CLBP).
- Trial name
- NCT01914666
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 151 people
- Sponsor
- Eli Lilly and Company
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Degenerative Disc Disease, Lumbar Spondylosis
Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease
The main objectives of this study are to evaluate the benefits of back bracing in the symptomatic management of patients with CLBP due to degenerative lumbar disc disease.
- Conditions
- Degenerative Disc Disease, Lumbar Spondylosis, Low Back Pain
- Trial name
- NCT03484403
- Testing
- Lumbar back brace, Back school
- Volunteers
- 61 people
- Sponsor
- Dallas VA Medical Center