Clinical trials: Chronic Low-back Pain
Chronic Low Back Pain
Yoga for Veterans With CLBP
Chronic low back pain (CLBP) is a prevalent condition among VA patients, but many current treatment options have limited effectiveness.
- Trial name
- NCT02524158
- Testing
- Yoga Therapy for CLBP
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- VA Office of Research and Development
Pain, Low Back Pain
Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain
The purpose of this study is to determine whether buprenorphine hydrochloride (HCl) buccal film is effective and safe in the treatment of chronic low back pain (CLBP).
- Trial name
- NCT01256450
- Testing
- Buprenorphine
- Where
- 24 sites in United States
- Volunteers
- 334 people
- Sponsor
- BioDelivery Sciences International
Chronic Low Back Pain, Posttraumatic Stress Disorder
Exercise Maintenance in Chronic Pain and PTSD
The primary purpose of the R21 is using an experimental medicine research approach to study whether a chronic, progressive-based exercise program will help Veterans suffering from chronic low back pain (cLBP) and PTSD achieve…
- Trial name
- NCT03644927
- Testing
- Progressive exercise training, Waitlist Control
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Back Pain Lower Back Chronic
Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Low Back Pain
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) 20 in comparison to the buprenorphine transdermal system (BTDS) 5 and oxycodone immediate-release in…
- Trial name
- NCT00313014
- Testing
- Buprenorphine, Oxycodone Immediate-Release
- Where
- 85 sites in United States
- Volunteers
- 660 people
- Sponsor
- Purdue Pharma LP
Back Pain Lower Back Chronic
Examining Racial and SocioEconomic Disparities (ERASED) in Chronic Low Back Pain Study
It remains unclear whether certain disadvantaged subgroups of society may be at heightened risk for poor chronic low back pain (cLBP) outcomes.
- Trial name
- ERASED (NCT03338192)
- Testing
- QST
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- University of Alabama at Birmingham
Lower Back Pain
Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans
The study design is a randomized, double-blind, two-arm trial of pregnenolone and placebo to determine the possible analgesic effects in OEF/OIF Veterans with chronic low back pain.
- Trial name
- NCT01898013
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Durham VA Medical Center
Acute Pain, Low Back Pain, Mechanical
Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
This is a study of adults with acute low back pain flare-up at risk of becoming chronic and disabling. The study tests how well spinal manipulation and guided selfcare work compared to standard medical care.
- Trial name
- PACBACK (NCT03581123)
- Testing
- Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Low Back Pain
The Glucosamine-study: The Effect of Glucosamine in Treatment of Chronic Low Back Pain
Low back pain (LBP) is the most frequent cause of sick leave and disability pension, and degenerative and osteoarthritic (OA) changes is a significant cause of pain and disability.
- Trial name
- NCT00404079
- Testing
- Glucosamine sulphate
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Chronic Pain
Study to Evaluate the Effectiveness of DRG Stimulation for Discogenic Low Back Pain
The purpose of this prospective post market observational pilot study is to evaluate the effect of DRG stimulation in the management of chronic discogenic pain in subjects who are refractory to other available treatments.
- Trial name
- NCT02587637
- Testing
- Dorsal root ganglion (DRG) stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Chronic Low Back Pain
Rage Against the Pain to Address Chronic Low Back Pain Among Veterans
Chronic low back pain is a leading cause of disability among Veterans. Yoga is recommended as a front-line treatment option for chronic low back pain and is available across the VA healthcare system; however, despite yoga being…
- Trial name
- RAP (NCT05103475)
- Testing
- Rage Against the Pain (RAP), Control
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Chronic Low Back Pain
Flurbiprofen Tape for Treatment of Chronic Low Back Pain
The purpose of this trial is to evaluate the analgesic efficacy and safety of flurbiprofen tape for chronic low back pain (lasting greater than 3 months).
- Trial name
- LBP (NCT00759330)
- Testing
- Flurbiprofen Tape (Arm 2), Flurbiprofen Tape (Arm 4)
- Where
- 10 sites in United States
- Volunteers
- 127 people
- Sponsor
- Teikoku Pharma USA, Inc.
Chronic Low-back Pain, Anxiety
EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain
The aim of this randomized controlled trial (RCT) is to assess outcomes for virtual reality therapy (including pain intensity, pain interference, anxiety, depression, physical function, sleep, behavioral skills development…
- Conditions
- Chronic Low-back Pain, Anxiety, Depression
- Trial name
- AVR_HEOR (NCT05263037)
- Testing
- EaseVRx
- Where
- United States
- Volunteers
- 1,093 people
- Sponsor
- AppliedVR Inc.
Chronic Pain, Back Pain
Group-based Mindfulness for Chronic Pain in the Primary Care Setting
The purpose of this pragmatic clinical trial (PCT) research is to determine whether a group-visit approach modeled on Mindfulness-Based Stress Reduction can improve function for persons with chronic low back pain.
- Trial name
- OPTIMUM (NCT04129450)
- Testing
- Group medical visits with mindfulness-based stress reduction, Usual PCP care
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Boston Medical Center
Chronic Low Back Pain
Chronic Low Back Pain Research Project
The purpose of this study is to determine whether gabapentin is efficacious as an analgesic for chronic low back pain.
- Trial name
- NCT00108550
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- US Department of Veterans Affairs
Low Back Pain, Low Back Sprain
Usability of a Multimodal External Neuromodulatory Device to Relieve Acute Low Back Pain
Ten patients with acute or chronic low back pain will be invited to try a multimodal device for 20 minutes. Pain will be recorded prior to and after use, and feedback on the device will be elicited.
- Conditions
- Low Back Pain, Low Back Sprain, Low Back Pain, Recurrent
- Trial name
- NCT04494841
- Testing
- Duotherm VibraCool Back Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MMJ Labs LLC
Low Back Pain, Recurrent
Treatment of Veterans With Chronic Low Back Pain
The purpose of this study is to assess the effectiveness of hypnosis in the treatment of chronic low back pain.
- Trial name
- CLBP (NCT00361270)
- Testing
- Hyp-8, Hyp-2 w recordings, Hyp-8 w recordings
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets
This is a 6-month, nonrandomized, open-label extension study to assess the long-term safety of hydrocodone bitartrate extended-release (ER) tablets in patients with moderate to severe chronic low back pain who require continuous…
- Trial name
- NCT01922739
- Testing
- Hydrocodone ER
- Where
- 61 sites in United States
- Volunteers
- 182 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Low Back Pain
Comparison of Kinesio Taping and Local Injection in Chronic Low Back Pain
Low back pain can be seen in every period of life. More than 80 percent of the society complain of low back pain at any time of life.
- Trial name
- NCT03895307
- Testing
- kinesio tape, local anesthetic, local serum physiologic
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Post-Traumatic Stress Disorder, Chronic Low Back Pain
Yoga and Mantram for Chronic Pain and PTSD
PTSD is prevalent among Veterans and is associated with physical and functional impairments in addition to PTSD symptoms. Veterans with PTSD experience more chronic pain and pain-related functional limitations than Veterans…
- Conditions
- Post-Traumatic Stress Disorder, Chronic Low Back Pain, Chronic Neck Pain
- Trial name
- NCT03816007
- Testing
- Yoga and Mantram Repetition, Veteran Calm
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen