Clinical trials: Chronic Low-back Pain (cLBP)
Chronic Low-back Pain (cLBP)
Effectiveness of Radial Extracorporeal Shockwave Therapy in Patients With Chronic Low Back Pain
Analysis of the effectiveness of radial shock wave therapy as part of a multimodal pain therapy in the inpatient setting. Different therapy protocols are compared in previously non-operated and in previously operated patients.
- Trial name
- ShockEffect (NCT05308641)
- Testing
- radial extracorporeal shockwave therapy_4000_20, radial extracorporeal shockwave therapy_500_2, standard multimodal pain therapy
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Ruhr University of Bochum
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low Back Pain
Oxycodone DETERx™ Versus Placebo in Chronic Low Back Pain (CLBP)
The purpose of this study is to evaluate the analgesic efficacy of Oxycodone DETERx compared with placebo in opioid-experienced and opioid-naive subjects with moderate-to-severe chronic low back pain requiring around-the-clock…
- Trial name
- NCT01685684
- Testing
- Oxycodone DETERx
- Where
- 45 sites in United States
- Volunteers
- 740 people
- Sponsor
- Collegium Pharmaceutical, Inc.
Chronic Low Back Pain (CLBP)
A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain
This study is a prospective, multi-center study designed to compare the safety and efficacy of spinal cord induced muscle stimulation (MuscleSCS) for the treatment of chronic low back pain.
- Trial name
- MuscleSCS (NCT07215104)
- Testing
- MuscleSCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Francis Hospital
Chronic Low Back Pain (Non-specific, Uncomplicated), Chronic Low Back Pain (CLBP)
Chronic Low Back Pain Comorbidities: Unravelling Impaired Glucose Metabolism
Chronic low back pain (CLBP) is a global health problem. The first step for developing effective treatments is a better understanding of underlying mechanisms, including its comorbidities.
- Trial name
- GLOW (NCT07734714)
- Testing
- Glucose beverage, Isomaltulose beverage, Standardized breakfast
- Where
- Belgium
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low-back Pain (cLBP)
Visual Feedback Manipulation in Virtual Reality Alters Extension-evoked Pain Perception in Chronic LBP
This study investigates the potential to modify movement-evoked pain in individuals with chronic low back pain (LBP) by manipulating visual proprioceptive feedback through virtual reality (VR).
- Trial name
- CLEVER BODY (NCT06750900)
- Testing
- NORMAL CONDITION, UNDERSTATED CONDITION, OVERSTATED CONDITION
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Chronic Low Back Pain (CLBP), Physical Therapy
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
The purpose of this research study is to investigate whether a single administration of psilocybin can improve interoceptive awareness (awareness of bodily sensations) in individuals with chronic low back pain undergoing physical…
- Conditions
- Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin
- Trial name
- NCT07306364
- Testing
- Psilocybin 10 mg, Psilocybin 25 mg, Niacin 100 mg
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Low Back Pain (CLBP)
Voice-Derived Acoustic Features and Pain Intensity in Chronic Low Back Pain
This observational study investigated whether characteristics of a person's voice are associated with pain intensity in adults with chronic low back pain and whether voice recordings can help predict individual pain levels.
- Trial name
- NCT07078019
- Testing
- Voice Recording Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- nurmuhammet tas
Chronic Low-back Pain
VANISH for Chronic Low Back Pain
The program, called TMC-CP01, will use a combination of virtual reality, biofeedback, and psychological exercises to manage pain associated with Chronic Low Back Pain.
- Trial name
- VANISH (NCT04236804)
- Testing
- Flowly (TMC-CP01)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ajay Wasan, MD, Msc
Chronic Low Back Pain (CLBP)
Impairment Based Treatment Versus Modified Functional Restoration Program in Chronic Low Back Pain Patients
The aim of this feasibility study is to evaluate the practicality of conducting a future randomized controlled trial comparing two rehabilitation approaches for older adults with degenerative chronic low back pain…
- Trial name
- FIRM-CLBP (NCT07699419)
- Testing
- Impairment-based trearment, Modified Functional restoration program
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Low Back Pain (CLBP)
Lumbar Extension Strengthening in Addition to Manual Therapy and Exercise for Chronic Low Back Pain
The goal of this clinical trial is to determine the effect of adding lumbar strengthening exercises to a program of manual therapy and motor control exercises (standard therapy) in adults with chronic low back pain (cLBP).
- Trial name
- NCT07719452
- Testing
- Standard Physical Therapy, Lumbar Extensor Strengthening plus Standard Physical Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brooke Army Medical Center
Overweight or Obesity, Chronic Low-back Pain
Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT
Chronic low back pain (CLBP) is the most expensive cause of workrelated disability: it causes the highest number of years lived with disability.
- Trial name
- BO2WL (NCT05811624)
- Testing
- Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone.
- Where
- 2 sites in Belgium, Switzerland
- Volunteers
- 252 people
- Sponsor
- Vrije Universiteit Brussel
Chronic Low Back Pain
Effects of OMT on Interoception
Recent evidence suggested that the anterior insula cortex seems to be the main site of interoception. Several studies showed an association between change in insula function and interoception, bodily perception and consciousness…
- Trial name
- NCT02464475
- Testing
- osteopathic manipulative treatment
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Come Collaboration
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Meralgia Paresthetica, Chronic Low-back Pain (cLBP)
Dry Needling Versus Cyriax Technique on Pain, Paraesthesia and Functional Disability in Patients With Chronic Low Back Pain
This study is designed to compare the effectiveness of two physiotherapy techniques-Dry Needling and the Cyriax Technique-in people suffering from chronic low back pain (CLBP) that radiates to the outer thigh, a condition…
- Trial name
- NCT07089472
- Testing
- Dry Needling Therapy, Cyriax Technique
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- University of Lahore
Osteoarthritis, Knee, Osteoarthritis, Hip
Open Label Safety and Tolerability Study of COV155 in Subjects With Osteoarthritis (OA) or Chronic Low Back Pain (CLBP)
A study to show the safety of COV155 in patients with osteoarthritis of the knee or hip or moderate to severe chronic low back pain.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Low Back Pain
- Trial name
- NCT01722864
- Testing
- COV155
- Where
- 34 sites in United States
- Volunteers
- 153 people
- Sponsor
- Mallinckrodt
Pain Threshold, Low Back Pain
Relationship Between Pressure Pain Threshold and Pain Intensity, Affect and Disability in CLBP
The association between pressure pain threshold and different aspects of low back pain has garnered attention over the years. However, since most of such studies in the past employed cross sectional designs, a longitudinal study…
- Conditions
- Pain Threshold, Low Back Pain, Pain Measurement
- Trial name
- NCT04482075
- Testing
- segmental stability training
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Dow University of Health Sciences
Chronic Low Back Pain (CLBP)
Effects of Repetitive Transcranial Magnetic Stimulation on Pain Thresholds in Patients With Chronic Low Back Pain
Chronic low back pain (CLBP) is a common reason for which patients are treated with opioids. Because the misuse of prescription opioids has become a serious problem in the Uinted States, finding effective alternative…
- Trial name
- NCT03973788
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Low Back Pain
Effect of the LumbaCure® Intervention on Elderly Patients Suffering From cLBP.
The goal of this investigation is to evaluate the safety and efficacy of the LumbaCure® device in elderly people suffering from low back pain.
- Trial name
- LumbaCure2303 (NCT06203886)
- Testing
- LumbaCure
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Odix
Chronic Low Back Pain (CLBP)
Traditional Medicine Use in Low Back Pain
Chronic low back pain (CLBP) is classified as one of the leading causes of disability worldwide. Furthermore, the painful experience of CLBP can be influenced by some already established factors, such as beliefs, self-efficacy…
- Trial name
- TMLBP (NCT06627101)
- Volunteers
- 273 people
- Sponsor
- Federal University of Amapa