Clinical trials: Chronic Low-back Pain (cLBP)
MSK Conditions, Chronic Low Back Pain (CLBP)
Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial
The goal of this clinical trial is to learn if antibiotics (amoxicillin) work to treat chronic low back pain in adults. In some patients, this type of back pain may be caused by bacteria in the vertebrae, resulting in a condition…
- Conditions
- MSK Conditions, Chronic Low Back Pain (CLBP), Modic Changes
- Trial name
- ABBA (NCT06771492)
- Testing
- Amoxicillin
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Bart Koes
Chronic Low Back Pain (CLBP)
Pain Neurophysiology Education in Chronic Low Back Pain
The investigators conducted a randomized controlled study including 22 patients suffering from chronic common low back pain. Patients were randomized into 2 groups: Control group received conventional rehabilitation only (11…
- Trial name
- PNE-LBP (NCT06915532)
- Testing
- Pain Neurophysiology Education, conventional rehabilitation
- Where
- Tunisia
- Volunteers
- 22 people
- Sponsor
- Hopital Charles Nicolle
Chronic Low Back Pain
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
The primary purpose of the study was to test the efficacy of 2 tablets (twice daily) of ABT-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain…
- Trial name
- NCT00761150
- Testing
- ABT-712
- Where
- 32 sites in United States
- Volunteers
- 308 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Chronic Low Back Pain (CLBP)
Egoscue and Core Stabilization for Chronic Low Back Pain
Chronic low back pain is a widespread musculoskeletal condition that limits mobility and affects quality of life. It is often caused due to the poor posture, hyperlordosis and weak core muscles.
- Trial name
- NCT07684118
- Testing
- Egoscue exercises, Core stabilization exercises
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
Chronic Low Back Pain
Transcranial Stimulation for Physiotherapy Optimisation - Chronic Low Back Pain (STOP-CLBP)
The main objective of this study is to investigate the effects of non-invasive brain stimulation (the so-called transcranial direct current stimulation ; tDCS) combined with an active physiotherapy program on the multidimensional…
- Trial name
- STOP-CLBP (NCT05757609)
- Testing
- Anodal tDCS combined with active physiotherapy
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Stephane ARMAND
Chronic Low Back Pain (CLBP)
Percussive Massage Therapy Using Heat Attachment in Chronic Low Back Pain
Low back pain is a global problem that currently affects many people's participation in daily activities, and its prevalence has been increasing over the years.
- Trial name
- NCT07346651
- Testing
- Percussive Massage Therapy, Exercise Training (Conventional Rehabilitation), Transcutaneous Electrical Nerve Stimulation (Conventional Rehabilitation)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Fenerbahce University
Low Back Pain, Mechanical
Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBP
This study compares the efficacy of medial branch block (MBB) vs. paravertebral deep intramuscular (PDI) injection for pain relief in chronic low back pain.
- Trial name
- NCT02521519
- Testing
- Medial branch block in one side, paravertebral deep intramuscular (PDI) injection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Chronic Low-back Pain (cLBP), Non-specific Low Back Pain (NSLBP)
Hybrid mHealth for Low Back Pain
The goal of this clinical trial is to evaluate whether adding a WhatsApp-based AI chatbot to standard physiotherapy and psychological care can improve self-management and outcomes in adults aged 18-65 with chronic low back pain…
- Trial name
- NCT07902778
- Testing
- Face-to-face physiotherapy and psychological care (for hybrid arm), WhatsApp-based AI chatbot for self-management (for hybrid and WhatsApp-only arms), Face-to-face physiotherapy and psychological care (No Digital Support) (for control arm)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Low-back Pain (cLBP)
Clinical Research of Effectiveness and Safety of Herbal Medicine Strategy for Chronic Low Back Pain
This study is a pragmatic multicenter randomized controlled trial evaluating the effectiveness and safety of herbal medicine strategy for chronic low back pain, using standard Korean medicine treatment as the control.
- Trial name
- NCT07058376
- Testing
- Herbal Medicine Strategy, Standard Korean Medicine Treatment
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Jaseng Medical Foundation
Low Back Pain, Recurrent, Chronic Low Back Pain (CLBP)
Magnetic Resonance Elastography Of Chronic Low Back Pain Before And After Therapy
The purpose of this study is to quantify Magnetic Resonance Elastography (MRE)-derived mechanical property biomarkers of the lumbar paraspinal musculature and associated myofascial tissue regions before and after the intervention.
- Trial name
- NCT07712458
- Testing
- EMMA (Expert Manipulative Massage Automation)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Low Back Pain, Chronic Low-back Pain (cLBP)
Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)
This study tests whether a virtually delivered integrated tai chi, qigong, and meditation program, added to usual care, improves chronic low back pain, disability, quality of life, and healthcare costs compared with usual care…
- Trial name
- NCT07772154
- Testing
- Virtually Delivered Integrated Tai Chi, Qigong, and Meditation (VDTQM)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- New York Medical College
Low Back Pain
Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects
The purpose of the study is to determine if buprenorphine hydrochloride (HCl) buccal film is effective in treating opioid-experienced subjects, with moderate to severe chronic low back pain (CLBP), who require continuous…
- Trial name
- NCT01675167
- Testing
- Buprenorphine
- Where
- 66 sites in United States
- Volunteers
- 815 people
- Sponsor
- BioDelivery Sciences International
Chronic Low Back Pain
Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component
Objective: The objective of this study is to compare the efficacy of duloxetine in the treatment of patients with chronic low back pain with a radicular component to placebo.
- Trial name
- NCT01166048
- Testing
- Duloxetine
- Where
- Austria
- Volunteers
- 41 people
- Sponsor
- Medical University of Vienna
Chronic Low Back Pain (CLBP), Musculoskeletal Pain
Virtual Reality-Based Rehabilitation in Chronic Low Back Pain: Effects on Muscle Architecture, Balance, and Satisfaction (VR-LBPREHAB)
Chronic low back pain is a common musculoskeletal disorder that causes pain, disability, and reduced quality of life. It is often related to changes in trunk muscle function, thoracolumbar fascia morphology, and impaired balance…
- Conditions
- Chronic Low Back Pain (CLBP), Musculoskeletal Pain, Postural Balance, Exercise Therapy
- Trial name
- VR-LBPREHAB (NCT07172828)
- Testing
- Virtual Reality-Based Rehabilitation, Conventional Motor Control Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Hacettepe University
Chronic Lower Back Pain (CLBP)
Mechanistic Evaluation of Polypharmacy Effects for Pain
This is a single-group, within-subject, double-blind, double-dummy, placebo-controlled study evaluating whether gabapentin (Neurontin) changes the analgesic, safety, and subjective effects of the opioid hydromorphone (Dilaudid)…
- Trial name
- PAT (NCT07846020)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Maryland, Baltimore
Low Back Pain, Paraspinal Muscles
Transcutaneous Electrical Nerve Stimulation (TENS) for the Treatment of Low Back Pain (LBP) in Adults
The goal of this clinical trial is to assess the effects and safety of transcutaneous electrical nerve stimulation (TENS) in adults with myofascial low back pain.
- Conditions
- Low Back Pain, Paraspinal Muscles, CLBP - Chronic Low Back Pain
- Trial name
- NCT07368920
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Low Back Pain
Relationship Between Kinesiophobia, Physical Activity and Disability Level and Pain Management in Patients With CLBP
The aim of this study was to examine the relationship between pain management, kinesiophobia, physical activity and disability level in patients with chronic low back pain (CLBP) in different genders.
- Trial name
- NCT06125496
- Testing
- Pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Alanya Alaaddin Keykubat University
Chronic Low Back Pain (CLBP)
Clinical Research on the Comparative Effectiveness and Safety of JHG002 Therapy for Chronic Low Back Pain: A Multicenter Randomized Controlled Trial
A multicenter randomized controlled trial
- Trial name
- NCT07304076
- Testing
- Hominis placental pharmacopuncture, Tanscutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in South Korea
- Volunteers
- 96 people
- Sponsor
- Jaseng Medical Foundation
Chronic Low Back Pain (CLBP), Intervertebral Disc Displacement
Sustained Acoustic Medicine for Chronic Low Back Pain Secondary to Herniated Nucleus Pulposus or Other Conditions
ZetrOZ's Ultrasonic Diathermy device is intended for use as a portable and wearable medical device which, when applied to various areas of the body applies Low Intensity Therapeutic Ultrasound (LITUS) to deep tissues.
- Trial name
- NCT02609854
- Testing
- Sustained Acoustic Medicine (SAM)
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- ZetrOZ, Inc.