Clinical trials: Chronic Lower Back Pain (CLBP)
Low Back Pain, Paraspinal Muscle
Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults
The goal of this clinical trial is to assess the clinical efficacy and safety of sodium aescinate in treating low back pain (LBP) in adult participants.
- Conditions
- Low Back Pain, Paraspinal Muscle, CLBP - Chronic Low Back Pain, Non-specific Chronic Low Back Pain
- Trial name
- NCT07339631
- Testing
- Sodium Aescinate Tablets
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Chronic Lower Back Pain (CLBP)
Brief Pain Reprocessing Therapy in Veterans
This research is studying whether a Zoom-based behavioral intervention may have an impact as a treatment for Veterans with Chronic Low Back Pain (CLBP).
- Trial name
- NCT06771713
- Testing
- Brief Pain Reprocessing Therapy (BPRT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Chronic Low Back Pain (CLBP)
SENECA - Smart Therapies for Chronic Pain
This will be a randomized controlled prospective pilot study: The feasibility and usability of VIVO 2nd GEN therapy + Standard-of-Care (SoC) vs. Standard-of-Care alone will be evaluated.
- Trial name
- SENECA (NCT07628179)
- Testing
- VIVO 2nd GEN, Standard-of-Care Multimodal Pain Therapy
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Aurimod GmbH
Chronic Low-back Pain (cLBP)
Virtual Reality Based High-intensity Interval Training in Chronic Low Back Pain
One of the most prevalent causes of pain on a global scale is chronic musculoskeletal pain. Low back pain is a prevalent manifestation of chronic musculoskeletal pain.
- Trial name
- NCT07388134
- Testing
- Virtual reality based high intensity interval training (VR-HIIT) group, High intensity interval training (HIIT) group
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Universidad de Granada
Chronic Low Back Pain (CLBP)
A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain
This study is a prospective, multi-center study designed to compare the safety and efficacy of spinal cord induced muscle stimulation (MuscleSCS) for the treatment of chronic low back pain.
- Trial name
- MuscleSCS (NCT07215104)
- Testing
- MuscleSCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Francis Hospital
Chronic Low Back Pain
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
The primary purpose of the study was to test the efficacy of 2 tablets (twice daily) of ABT-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain…
- Trial name
- NCT00761150
- Testing
- ABT-712
- Where
- 32 sites in United States
- Volunteers
- 308 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Low Back Pain
Effects of Bilateral Asymmetrical Limbs Proprioceptive Neuromuscular Facilitation on Multifidus Muscle in CLBP.
The low back pain is a leading cause to limit individual functional activities worldwide and 60%-80% of adults are probable to get low back pain at least once in life time.
- Trial name
- NCT04206137
- Testing
- Group A (PNF rhythmic initiation group ), Group B (Swiss ball exercises)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- University of Karachi
Chronic Low-back Pain (cLBP)
Effects of Vertebral Axial Loading Walking Combined With Core Stabilization Exercises in Individuals With Chronic Low Back Pain
Chronic low back pain is a common musculoskeletal condition persisting for more than three months and is associated with pain, functional limitations, impaired balance, altered proprioception, reduced trunk muscle performance…
- Trial name
- NCT07334782
- Testing
- Exercise - Core Stabilization Exercise Program, Core Stabilization Exercises Plus Vertebral Axial Loading Walking Training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Low Back Pain, Chronic Low-back Pain (cLBP)
Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)
This study tests whether a virtually delivered integrated tai chi, qigong, and meditation program, added to usual care, improves chronic low back pain, disability, quality of life, and healthcare costs compared with usual care…
- Trial name
- NCT07772154
- Testing
- Virtually Delivered Integrated Tai Chi, Qigong, and Meditation (VDTQM)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- New York Medical College
CLBP - Chronic Low Back Pain
Effect Virtual Reality Fully Immersive Based Exercise Game on Reducing Fear of Movement in People With CLBP
Low back pain is one of the most common problems among adults and a leading cause of disability worldwide including in Saudi Arabia (Buchbinder et al., 2018) (Awaji, 2016) .
- Trial name
- NCT05267756
- Testing
- (kurki-application),VR glasses
- Where
- Saudi Arabia
- Volunteers
- 28 people
- Sponsor
- King Saud University
Chronic Low-back Pain (cLBP), Chronic Low-back Pain
Effectiveness of a Multidisciplinary Treatment for Patients With Chronic Low Back Pain
PAINDOC is a treatment program that includes 4 disciplines that, separately, have demonstrated their effectiveness in the treatment of chronic low back pain: education in pain neuroscience, therapeutic education (Empowered…
- Conditions
- Chronic Low-back Pain (cLBP), Chronic Low-back Pain, Back Pain
- Trial name
- PAINDOC (NCT06679205)
- Testing
- Multidisciplinary and multimodal intervention, Usual Care
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Chronic Low-back Pain (cLBP)
Acceptance and Commitment Therapy Plus Exercise for Older People With Chronic Low-back Pain: A Pragmatic Cluster Randomised Controlled Trial
Low back pain (LBP) is the fifth-most common disorder among older adults 60 years or older. The prevalence of LBP increases with age, with the highest prevalence occurring at 85 years old.
- Trial name
- NCT07211464
- Testing
- Acceptance and commitment therapy (ACT), back exercise, back care education
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Low-back Pain (cLBP)
Effects of a Hip Flexor and Extensor Muscle Training Program in Individuals with Chronic Mechanical Low Back Pain
The goal of this clinical trial is to evaluate the effect of a physiotherapy intervention program in the lumbopelvic area in chronic low back pain patients. The main questions it aims to answer are: 1.
- Trial name
- NCT06787209
- Testing
- Program to improve lumbopelvic function., generic health care
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Lucía Pilar Vicente Pina
Chronic Low Back Pain (CLBP)
Disc Puncture Does Not Accelerate Degenerative Changes in Lumbar Discs of Patients With Discogenic Pain
Procedures 10 years ago performed included intradiscal nucleoplasty (ACUTHERM) and intradiscal electrothermal therapy (IDET). At follow up MRI scans evaluated by two blinded specialists for disc degeneration were carried out.
- Trial name
- NCT07567404
- Testing
- Intradiscal electrothermal Therapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- SRH Gesundheitszentrum Bad Herrenalb
Chronic Low Back Pain
Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)
The primary purpose of the study is to test the efficacy of 2 tablets (twice daily) of ABT-712, compared to placebo, administered over a 4-week period in participants with moderate to severe mechanical chronic low back pain…
- Trial name
- NCT00763321
- Testing
- ABT-712
- Where
- 31 sites in United States
- Volunteers
- 287 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Chronic Low-back Pain (cLBP), Myofacial Pain
Treatment Validation for Myofascial Pain
The goal of this clinical trial is to see if a body test called the NUN biomarker can track changes in chronic low back pain after dry needling and predict who will feel better.
- Trial name
- NCT07133139
- Testing
- Dry Needling, NUN Biomarker
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ajay Wasan, MD, Msc
Chronic Low Back Pain (CLBP)
Comparison of the Immediate Effect of Passive vs. Passive-Active Hamstring Stretching on Flexibility in Patients With Chronic Low Back Pain
The goal of this clinical trial is to determine whether a combination of passive and active hamstring stretching (PAS) is more effective than passive stretching alone (PS) in improving flexibility in patients with chronic low…
- Trial name
- EFIM2 (NCT06888895)
- Testing
- Passive-active stretching (PAS), Passive hamstring stretching
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Low Back Pain, Mechanical
Short Terms Effects of Medial Branch Block vs Para-spinal Muscle Injection in Patients With Non-specific CLBP
This study compares the efficacy of medial branch block (MBB) vs. paravertebral deep intramuscular (PDI) injection for pain relief in chronic low back pain.
- Trial name
- NCT02521519
- Testing
- Medial branch block in one side, paravertebral deep intramuscular (PDI) injection
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Low-back Pain (cLBP)
Exercise-Based Strategies for Chronic Back Pain
This randomized, controlled, five-arm, parallel-group trial will evaluate the effects of 8 weeks of supervised resistance training and developmental position-based exercise, with or without real-time non-invasive intra-abdominal…
- Trial name
- BACK-FIT (NCT07475481)
- Testing
- Gym settings, Physio settings, Home - based settings: exercises based on developmental positions
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Chronic Low Back Pain (CLBP)
Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured Adults With Chronic Low Back Pain
Chronic low back pain (cLBP) is a leading cause of disability, with socioeconomically disadvantaged populations experiencing worse outcomes and lower rates of treatment initiation for evidence-based pain psychology services.
- Trial name
- NCT07843706
- Testing
- Empowering Pain Psychology Access and Collaboration (EPPAC), Usual Care Pain Psychology Evaluation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University