Clinical trials: Chronic Lung Disease
COPD, Chronic Obstructive Pulmonary Disease
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care.
- Trial name
- AIRFLOW-4 (NCT07051707)
- Testing
- Targeted Lung Denervation (TLD)
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nuvaira, Inc.
Pulmonary Emphysema
Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE)
The purpose of this study is to demonstrate the safety and efficacy of AeriSeal System treatment plus optimal medical therapy compared in patients with advanced upper lobe predominant (ULP) heterogeneous emphysema.
- Trial name
- ASPIRE (NCT01449292)
- Testing
- Treatment plus Optimal Medical Therapy, Optimal Medical Therapy
- Where
- 40 sites in United States, France and 5 more
- Volunteers
- 300 people
- Sponsor
- Aeris Therapeutics
Chronic Obstructive Pulmonary Disease
Trial of Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease
The study null hypothesis is that vitamin D supplementation will not influence time to upper respiratory tract infection or time to moderate/severe exacerbation of chronic obstructive pulmonary disease.
- Trial name
- ViDiCO (NCT00977873)
- Testing
- Cholecalciferol, Miglyol oil
- Where
- 4 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- Barts & The London NHS Trust
Chronic Obstructive Pulmonary Disease
A Pilot- and Feasibility Trial of the EHealth Tool My COPD for People with COPD
The aim of this multi-center, randomized controlled pilot- and feasibility trial is to evaluate the user satisfaction, reach and safety of My COPD, a novel eHealth tool for remote delivery of evidence-based treatment targeting…
- Trial name
- My COPD (NCT05086341)
- Testing
- My COPD
- Where
- 2 sites in Sweden
- Volunteers
- 22 people
- Sponsor
- Umeå University
Cystic Fibrosis, Chronic Disease
Measuring and Improving Coproduction Using coopeRATE
The purpose of this study is to identify new methods of measuring and improving collaborative goal setting between patients and clinicians in adult cystic fibrosis care.
- Trial name
- NCT04060329
- Testing
- coopeRATE Prompt
- Where
- 9 sites in United States
- Volunteers
- 280 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Noninvasive Ventilation, Chronic Disease Lung
Behavioural Intervention in Mechanically Ventilated Patients
Background: Non-invasive ventilation at home for chronic respiratory failure due to different etiologies has proven effective regarding mortality and quality of life.
- Trial name
- NCT03932175
- Testing
- Intervention group
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Hospital Clinic of Barcelona
Chronic Obstructive Pulmonary Disease
Exacerbation Study
This study compares indacaterol with tiotropium in terms of bronchodilation over 52 weeks
- Trial name
- INVIGORATE (NCT00845728)
- Testing
- Indacaterol 150 µg, Tiotropium
- Where
- 423 sites in Argentina, Australia and 38 more
- Volunteers
- 3,439 people
- Sponsor
- Novartis Pharmaceuticals
COPD
Optimizing Maintenance for Patients with COPD Via a Web Platform - Case Study
Pulmonary rehabilitation (PR) has been shown to improve quality of life of people with COPD by decreasing their symptoms. However, the benefits obtained during PR tend to decrease within six months to one year after PR.
- Trial name
- NCT04284865
- Testing
- Web Platform
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Université de Sherbrooke
COPD
Effect of Neuromuscular Electrical Stimulation Versus Cycle Ergometer Training in a Pulmonary Rehabilitation Program
The aim of this study is to evaluate the effectiveness of quadriceps strengthening with neuromuscular electrical stimulation versus cycle ergometer as part of pulmonary rehabilitation program , in patients with severe or very…
- Trial name
- ESNM (NCT02656667)
- Testing
- neuromuscular electrical stimulation, cycle ergometer training, Conventional pulmonary rehabilitation
- Where
- 2 sites in France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Brest
COPD
A Home-based Module to Promote Mindful Breathing Awareness for COPD Patients
The purpose of this study is to develop a mindful breathing module to an already effective and developed home based rehabilitation program for guiding COPD patients in a mindful breathing practice and further palliate…
- Trial name
- NCT04517500
- Testing
- Home-based pulmonary rehabilitation program, Mindful breathing module, Health coaching
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Move With Air: Exercise Training Study
The purpose of this study is to explore the role of a stream of cool air to the face, through fan-to-face therapy, as a novel adjunct non-pharmacological therapy to enable symptomatic adults with cardiopulmonary disease to…
- Conditions
- Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Heart Failure
- Trial name
- NCT05646407
- Testing
- Honeywell HT-900 Turbo Force Air Circulator
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University
Pulmonary Disease, Chronic Obstructive
Advair® DISKUS® Versus Serevent® DISKUS® For Chronic Obstructive Pulmonary Disease Exacerbations
This study evaluates the effect of two medicines on COPD (Chronic Obstructive Pulmonary Disease) exacerbations. This study will last up to 56 weeks, and subjects will visit the clinic 10 times.
- Trial name
- NCT00115492
- Testing
- Fluticasone Propionate/Salmeterol Combination Product, Salmeterol
- Where
- 110 sites in United States, Canada
- Volunteers
- 797 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Exacerbations and Real-World Outcomes Among Patients With Chronic Obstructive Pulmonary Disease Following Severe Exacerbation
This real-world retrospective study will use de-identified administrative claims data and will examine patients with a diagnosis of COPD who have experienced a qualifying severe disease exacerbation and received subsequent…
- Trial name
- NCT07414134
- Testing
- BGF- BUDESONIDE/GLYCOPYRRONIUM/FORMOTEROL
- Where
- United States
- Volunteers
- 3,598 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
TOPIC Trial for COPD
The study is a randomized, double-blind, placebo-controlled, multiple-dose, pilot study of orally-administered ivacaftor in subjects with chronic obstructive pulmonary disease.
- Trial name
- NCT02135432
- Testing
- Ivacaftor
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease
Digital Therapeutics on Inhalation Medication Adherence in COPD
Digital Therapeutics (DTx) is an evidence-based，clinically evaluated software to treat，manage，and prevent a broad spectrum of diseases and disorders according to Digital Therapeutics Alliance，which may improve the adherence of…
- Trial name
- NCT05667363
- Testing
- Digital Intervention
- Where
- China
- Volunteers
- 582 people
- Sponsor
- China-Japan Friendship Hospital
Cancer-related Fatigue, Breast Cancer
Guaraná Supplementation for Cancer-Related Fatigue
Cancer-related fatigue is one of the most common and distressing symptoms experienced by patients during and after cancer treatment, and current options to manage it are limited.
- Conditions
- Cancer-related Fatigue, Breast Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- GUARANA-CRF (NCT07816263)
- Testing
- Guaraná (Paullinia cupana)
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Chronic Obstructive Pulmonary Disease
Safety Study to Evaluate MN-221 in Chronic Obstructive Pulmonary Disease (COPD) Patients
In MediciNova's clinical development plan for MN-221, it was recognized that treatment of COPD exacerbations may necessitate more than one single i.v.
- Trial name
- NCT01551316
- Testing
- MN-221
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- MediciNova
SARS-CoV-2 Infection, COVID-19
An Open-label, Clinical Feasibility Study of the Efficacy of Remdesivir for Long-COVID.
Following an infection with Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV2), one in ten people will experience persisting symptoms, or develop symptoms which can last for months and even years.
- Trial name
- ERASE-LC (NCT05911906)
- Testing
- Remdesivir
- Where
- 4 sites in United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Derby
Emphysema, Pulmonary
Unilateral vs. Bilateral Lung Volume Reduction Surgery
This study compares two surgical approaches for patients with severe Chronic Obstructive Pulmonary Disease (COPD) and severe emphysema: unilateral (operating on one lung) versus bilateral (operating on both lungs) lung volume…
- Trial name
- NCT07731958
- Testing
- Unilateral LVRS, Bilateral LVRS
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bronchopulmonary Dysplasia, Lung Diseases
Inhaled NO in Prevention of Chronic Lung Disease
To test the hypothesis that low-dose inhaled nitric oxide administered to preterm infants who continue to require mechanical ventilation at 14 days of age will reduce the incidence of chronic lung disease.
- Trial name
- NCT00000548
- Testing
- mechanical ventilation
- Sponsor
- University of California, San Francisco
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