Clinical trials: Chronic Major Depression
Bipolar Disorder, Schizophrenia
Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness
Persons with serious mental illness are at increased risk of cardiovascular disease. The goals of this study are to test a treatment, Life Goals Collaborative Care to help promote health behavior change and to get feedback from…
- Conditions
- Bipolar Disorder, Schizophrenia, Major Depressive Disorder, Chronic Affective Disorders
- Trial name
- NCT01244854
- Testing
- Life Goals Collaborative Care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Major Depression
Cognitive Behavioral Treatments for Depression in Chronic Illness
Duke University Medical Center in collaboration with Glendale Adventist Medical Center propose a randomized clinical trial of conventional cognitive behavior therapy (CCBT) vs.
- Trial name
- NCT01208428
- Testing
- Conventional cognitive behavioral therapy, Religious cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Duke University
Chronic Depression
Cognitive Behavioural Analysis System of Psychotherapy (CBASp) Versus Escitalopram in Chronic Depression
60 patients with chronic major depressive disorder according to DSM-IV will be included into the study. Patients will be randomized to receive an open treatment either with CBASP, a psychotherapy for chronic depression, or…
- Trial name
- NCT00837564
- Testing
- CBASP psychotherapy, Escitalopram
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Freiburg
Pulmonary Disease, Chronic Obstructive, Major Depression
Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients
Approximately 20% of patients with chronic obstructive pulmonary disease (COPD) have major depression, a condition that contributes to suffering but also to poor treatment adherence leading to increased disability and morbidity.
- Trial name
- NCT00151372
- Testing
- Treatment Adherence Intervention, Enhanced Care
- Where
- 3 sites in United States
- Volunteers
- 141 people
- Sponsor
- Weill Medical College of Cornell University
Congestive Heart Failure, Diabetes
Evaluation of Programs of Coordinated Care and Disease Management
This is a Congressionally mandated study. In the original study, 16 demonstration programs provided care coordination services to beneficiaries with chronic illness in Medicare's fee-for-service program.
- Conditions
- Congestive Heart Failure, Diabetes, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- Coca (NCT00627029)
- Testing
- Care Coordination
- Where
- 15 sites in United States
- Volunteers
- 18,277 people
- Sponsor
- Mathematica Policy Research, Inc.
Dysthymic Disorder, Depressive Disorder NOS
Duloxetine for Chronic Depression: a Double-blind Study
The investigators are studying a new antidepressant medicine, duloxetine, for the treatment of people with chronic depression. Duloxetine (trade name Cymbalta) was recently approved by the FDA for the treatment of major…
- Trial name
- NCT00360724
- Testing
- Duloxetine (Cymbalta)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- New York State Psychiatric Institute
End Stage Renal Disease, Depression
Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes
The objective of this study is to determine the effect of music therapy during dialysis on: depression, anxiety, quality of life, blood pressure, heart rate, medication compliance, compliance with dialysis treatment, number of…
- Conditions
- End Stage Renal Disease, Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT03925168
- Testing
- Music therapy
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Tulane University
Insomnia, Depressive Disorder, Major
Cannabinoids as a Treatment for Insomnia in Major Depression
This single-site study is a pilot, three-armed, double-blinded, placebo-controlled randomized controlled trial (RCT) that will determine the feasibility of a definitive RCT investigating the use of cannabis oil as a treatment for…
- Conditions
- Insomnia, Depressive Disorder, Major, Sleep Disorder, Depression
- Trial name
- CANMDD (NCT05041647)
- Testing
- 25:1 CBD/THC, 5:1 CBD/THC
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Major Depression, Generalized Anxiety Disorder
Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines
The hypothesis of this study is that symptoms of anxiety, depression and insomnia; and indices of psychosocial function will all improve, while BZ use will decrease significantly during a twelve-week trial period of substituting…
- Trial name
- NCT01244711
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
Pharmacologic Treatment Augmentation in Chronic Depression
To enroll in this clinical trial, prospective participants must meet stringent criteria. The participants need to fall within the age range of 18 to 64 and exhibit chronic depression at therapy resistance stage 2.
- Trial name
- Ket+CBASP (NCT06410599)
- Testing
- Ketamine, CBASP, TAU
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Mild Cognitive Impairment (MCI), Dementia Alzheimer Type
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder
- Trial name
- KoCoA cohort (NCT07485387)
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University
Major Depressive Disorder
Treatment for Chronic Depression
The purpose of this study is to test the clinical efficacy of two psychotherapies for early onset chronic major depression, including Behavioral Activation (Jacobson et al., 2001), and an integrated version of Behavioral…
- Trial name
- NCT00204152
- Testing
- (Condition 1) Behavioral Activation; (Condition 2) Behavioral Activation and Stress Innoculation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Chicago
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Major Depressive Disorder
Brief Multifamily Psychoeducation for Families of Patients With Chronic Major Depression
The purpose of this study is to examine the effectiveness of brief multifamily psychoeducation to relieve the psychological distress of families of patients with chronic major depression and to improve their family functioning.
- Trial name
- NCT01734291
- Testing
- Family psychoeducation
- Where
- Japan
- Volunteers
- 49 people
- Sponsor
- Nagoya City University
Depression Chronic, Depression and Quality of Life
Remote Medical Monitoring of Patients With Depression
The goal of this clinical trial is to learn if ThIA Suivi, a digital tool for remote monitoring of patients, can improve the care of adults with depression who are followed by a psychiatrist.
- Conditions
- Depression Chronic, Depression and Quality of Life, Depression, Major Depressive Episode
- Trial name
- TELEMED-DEP (NCT07878754)
- Testing
- Use of ThIA Medical Device
- Where
- 3 sites in France
- Volunteers
- 608 people
- Sponsor
- ThIA Santé Mentale
Pain
Pharmacogenetic Morphine Spine Study
The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children cope with pain and respond to pain medication.
- Trial name
- NCT01839461
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Multimorbidity, Hypertension
Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity
This study aims to test a new comprehensive management service package for older adults with two or more chronic conditions (multimorbidity).
- Conditions
- Multimorbidity, Hypertension, Diabetes Mellitus, Coronary Artery Disease
- Trial name
- COMPASS (NCT07151430)
- Testing
- Service Package Group
- Volunteers
- 358 people
- Sponsor
- Xuanwu Hospital, Beijing
Chronic Depression, Persistent Depressive Disorder
Intensive Psychotherapy for Chronic Depression
The study evaluates whether Intensive psychotherapy show superior effect on chronic depression over TAU
- Conditions
- Chronic Depression, Persistent Depressive Disorder, Recurrent Major Depression
- Trial name
- NCT05221567
- Testing
- Psychotherapy
- Volunteers
- 280 people
- Sponsor
- Modum Bad
Major Depressive Disorder, Recurrent, Unspecified
Deep Brain Stimulation of Nucleus Accumbens for Chronic and Resistant Major Depressive Disorder
Depression is a common, recurrent and disabling disorder. Among patients with a chronic course of the disease, 20 to 30% are resistant to antidepressant medications.
- Trial name
- PRESTHYM (NCT01569711)
- Testing
- Deep brain stimulation of nucleus accumbens
- Where
- 10 sites in France
- Volunteers
- 6 people
- Sponsor
- Rennes University Hospital