Clinical trials: Chronic Migraine, Headaches
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Chronic Migraine
Trip-Tox, Effectiveness of Triptans Before and After Onabotulinumtoxin A Treatment in Chronic Migraine
Observational, longitudinal, prospective, prospective, comparative study of the effectiveness of triptans before and after onabotulintoxin A initiation in a single group of chronic migraine patients.
- Trial name
- NCT04871152
- Testing
- OnabotulinumtoxinA
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Migraine in Children, Pain, Neuropathic
Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients
Single-center, open-label, pre-post treatment pilot study to evaluate the safety and effectiveness of sphenopalatine ganglia blocks for the treatment of chronic migraine in the pediatric population.
- Trial name
- NCT04466826
- Testing
- Headache Journal, Sphenopalatine Block, Tx360
- Where
- United States
- Sponsor
- Washington University School of Medicine
Sphenopalatine Block, BOTOX
Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine
This trial compares the efficacy and safety of sphenopalatine ganglion block (SPGB) and intramuscular BOTOX injection in chronic migraine.
- Conditions
- Sphenopalatine Block, BOTOX, Chronic Migraine
- Trial name
- NCT06974617
- Testing
- Sphenopalatine block, Botulinum Toxin Type A
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Gulf War Illness, Persian Gulf Syndrome
Exercise in Gulf War Illness (GWI)
The purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of VO2MAX plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional…
- Trial name
- NCT01291758
- Testing
- Submaximal bicycle exercise stress tests performed 24 hr apart
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Migraine
A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine
The purpose of this study is to learn about the effect of a study medicine called rimegepant in adolescents who have frequent migraine attacks. Rimegepant is a tablet that disintegrates when you put it on or under your tongue.
- Trial name
- NCT06616194
- Testing
- Rimegepant
- Where
- 102 sites in United States, Canada and 10 more
- Volunteers
- 636 people
- Sponsor
- Pfizer
Migraine With and Without Aura, Chronic Migraine
Migraine and Body Composition
This research is being done to look at the association between migraine and obesity.
- Conditions
- Migraine With and Without Aura, Chronic Migraine, Healthy Controls
- Trial name
- NCT01720862
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Migraine
Treatment of Cervical Pain in Chronic Migraine
Chronic migraine (CM) is defined as a headache that occurs more than 15 days per month, which has the features of migraine headache on at least 8 days per month.1 The cause of CM is not well understood.
- Trial name
- NCT03453203
- Testing
- Osteopathic Manipulative Treatment Using Counterstrain
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Migraine
Evaluation of Galcanezumab in the Prevention of Chronic Migraine
The main purpose of this study is to evaluate the efficacy of the study drug known as galcanezumab in participants with chronic migraine.
- Trial name
- REGAIN (NCT02614261)
- Testing
- Galcanezumab
- Where
- 117 sites in United States, Argentina and 11 more
- Volunteers
- 1,117 people
- Sponsor
- Eli Lilly and Company
Chronic Migraine
Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine
Monoclonal antibodies (mABs) targeting calcitonin gene-related peptide (CGRP) proved effective in the preventive treatment of episodic and chronic migraine as well as in difficult-to-treat patients such as those who had…
- Trial name
- NCT04361721
- Testing
- Erenumab
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine Without Aura, Chronic Tension-Type Headache
Cortical Reorganisation in Patients With Primary Headache Disorders
Primary headache disorders are now accepted as physiological diseases, and advanced imaging-techniques have demonstrated a migraine generator in the brain stem and increased stimulus sensitivity in these patients.
- Trial name
- NCT00263991
- Testing
- EEC-techniques
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine, Headache
Long-term Atogepant in Real-world Practice
This prospective multicentre observational study aims to evaluate the long-term effectiveness, safety, tolerability, and treatment persistence of atogepant for migraine prevention in routine clinical practice.
- Conditions
- Migraine, Headache, Headache (Migraine), Migraine Disease
- Trial name
- GEMA PROJECT (NCT07699549)
- Testing
- Atogepant 60 mg, Headache diary, Patient-reported outcome measures
- Where
- Spain
- Volunteers
- 513 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Chronic Migraine
Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging Changes.
Pilot study evaluating effect of Botox injection treatment for 12 individuals suffering from chronic migraine on function MRI imaging, before and after treatment.
- Trial name
- NCT02436499
- Testing
- Botulinum Toxin-A
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
New Daily Persistent Headache, New Daily Persistent Headache (NDPH)
New Daily Persistent Headache Biomarkers Study
New daily persistent headache is a debilitating syndrome which is seldom researched, poorly understood, and without effective treatments. Chronic migraine is a more common but similarly disabling disorder.
- Trial name
- NDPH (NCT04260087)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Chronic Headache, Migraine
Assessment of the Effectiveness of Virtual Reality as a Learning Tool for Relaxation Techniques in Reducing Pediatric Migraines and Tension Type Headache
The goal of this interventional study is to assess the efficacy of a therapeutic intervention aimed at diminishing pediatric chronic headache.
- Conditions
- Chronic Headache, Migraine, Tension Type Headache
- Trial name
- NCT06921109
- Testing
- Experimental: Relaxation training with VR, Experimental: Relaxation training without VR, No Intervention: Control group
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University of Liege
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Migraine Headache
Ibudilast in the Treatment of Patients With Chronic Migraine.
This will be a double-blind, randomised, placebo-controlled, two period cross over study of ibudilast in the treatment of chronic migraine. For participants resident in Adelaide, South Australia (i.e.
- Trial name
- IBU-003 (NCT01389193)
- Testing
- Ibudilast
- Where
- Australia
- Volunteers
- 33 people
- Sponsor
- Parisa Gazerani
Greater Occipital Nerve Block, Medical Treatment
Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical Treatment
The aim of this work is to assess the efficacy of ultrasound guided greater occipital nerve block either by local anesthetic or by botulinum toxin in comparison to medical treatment in prevention of chronic migraine.
- Conditions
- Greater Occipital Nerve Block, Medical Treatment, Chronic Migraine
- Trial name
- NCT06122545
- Testing
- Greater Occipital Nerve Block, Medical Treatment, bupivacaine or onabotulinum toxin A injection.
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Migraine
Transcranial Direct Current Stimulation Associated With Mindfulness in Chronic Migraine
This study is a group controlled clinical trial. ParallelParallel study, patients aged 25-50 years, with Migraine Chronicle. Twelve sessions will be held during four mindfulness practice with four recordings (one per week).
- Trial name
- NCT04219345
- Testing
- Transcranial direct current stimulation
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Chronic Migraine
Saline Injections for Prophylactic Treatment of Chronic Migraine
In this study, the investigators want to investigate whether saline injections in the neck and head muscles can reduce symptoms of chronic migraine.
- Trial name
- NCT03919045
- Testing
- Saline injection
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Göteborg University