Clinical trials: Chronic Migraine Headache
Chronic Migraine
Non-Invasive Neurostimulation for the Prevention of Chronic Migraine
The purpose of this multi-center, prospective, double-blind, randomized, sham-controlled pilot study is to study feasibility and collect preliminary clinical data related to the safety and clinical benefits of daily use of…
- Trial name
- NCT01667250
- Testing
- GammaCore Active Device
- Where
- 6 sites in United States
- Volunteers
- 59 people
- Sponsor
- ElectroCore INC
Episodic Migraine, Chronic Daily Migraine
fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease?
This is a 2 visit research study for patients with or without a diagnosis of migraine. Participants will be administered informed consent, have a medical history taken and a physical examination performed, and complete 3…
- Trial name
- NCT00868556
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Migraine
Enfacement Illusion and Chronic Migraine Pain
The concept of body image can be described as "the intentional content of consciousness comprising perceptions, attitudes and beliefs relating to one's body".
- Trial name
- NCT04904458
- Testing
- Experimental group ("enfacement illusion"), Control Group (Pleasant virtual environment exposure)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Depression, Headaches Chronic
CBT Depression Intervention for Co-Occurring Chronic Headache
Having co-occurring depression and chronic headaches is challenging and can greatly impact one's professional, personal, family, and social life.
- Conditions
- Depression, Headaches Chronic, Migraine Disorders
- Trial name
- NCT02870725
- Testing
- CBT Individual Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Georgia
Chronic Migraine
Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action
The purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention.
- Trial name
- NCT04271202
- Testing
- Emgality 120 MG in 1 ML Prefilled Syringe
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Migraine, Insomnia
Efficacy of Behavioral Insomnia Treatment for Chronic Migraine
The purpose of this study is to test the efficacy of a brief behavioral insomnia intervention in reducing headache frequency and severity among patients with chronic migraine and insomnia.
- Trial name
- NCT01314651
- Testing
- Stimulus Control and Sleep Restriction, Lifestyle Modification
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Daniel Riche
Chronic Migraine, Headache, Temporomandibular Joint Dysfunction
The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine
The aim of this clinical study to evaluate the effect of temporomandibular joint dysfunction accompanying patients with chronic migraine on pain, quality of life, sleep and functionality.
- Conditions
- Chronic Migraine, Headache, Temporomandibular Joint Dysfunction, Chronic Pain, Quality of Life
- Trial name
- NCT05381129
- Testing
- Detection of Pain, Quality of Life, Sleep and Functioning, Temporomandibular joint dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istanbul University - Cerrahpasa
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
Chronic Migraine Headache
The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine
Chronic migraine is a disabling neurovascular disorder and one of the leading causes of years lived with disability worldwide. Population-based studies report a worrying level of resistance to currently available treatments in…
- Trial name
- SIGMA (NCT07617441)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Migraine Disorders
BOTOX® Prophylaxis in Patients With Chronic Migraine
This is a post authorization observational study to monitor the utilization practices and describe the safety profile of BOTOX® in clinical practice for the prophylactic treatment of headaches in adult patients with chronic…
- Trial name
- NCT01432379
- Testing
- botulinum toxin Type A
- Where
- 4 sites in Germany, Spain and 2 more
- Volunteers
- 1,168 people
- Sponsor
- Allergan
Chronic Migraine
Study of Oral Atogepant When Added to OnabotulinumtoxinA (BOTOX) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Chronic Migraine
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound.
- Trial name
- ATO-BOTOX (NCT05216263)
- Testing
- Atogepant
- Where
- 29 sites in United States
- Volunteers
- 75 people
- Sponsor
- AbbVie
Chronic Migraine
Intramuscular Electrical Stimulation for the Treatment of Trigger Points in Patients With Migraine
The goal of this single-case experimental study is to investigate the effects of intramuscular electrical stimulation for the treatment of trigger points on reducing the frequency of headaches in a small sample of patients with…
- Trial name
- NCT05893914
- Testing
- Dry Needling and intramuscular electrical stimulation to trigger points
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Thomas W. Perreault, PT
Migraine
A Study of Wearable Devices to Predict Migraines
The purpose of this research is to determine if data from smart devices, including heart rate and movement during sleep and wake times, will be able to track headaches and predict recurrence and exacerbations (make worse).
- Trial name
- NCT05755945
- Testing
- eHealth Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chronic Migraine, Pain
Anesthetic Blockades and Migraine
Greater occipital nerve (GON) anesthetic blockades are widely used for the treatment of headaches, yet its efficacy in migraine has hardly been assessed with controlled studies.
- Trial name
- NCT02188394
- Testing
- Anesthetic blockades with bupivacaine, Isotonic saline injection
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- César Fernández-de-las-Peñas
Chronic Migraine, Headache
Comparison of the Efficacy of Ultrasound-guided Greater Occipital Nerve Block and Pulsed Radiofrequency Therapy in Chronic Migraine Patients
Chronic migraine (CM) is related to headache-related disability and reduced quality of life. Therefore, patients with CM require preventive treatment.
- Trial name
- NCT05464212
- Testing
- USG Guided Greater Occipital Nerve Block, USG Guided Greater Occipital Nerve Block and Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Eskisehir Osmangazi University
Migraine Disorders
Evaluation of ALD403 (Eptinezumab) in the Prevention of Chronic Migraine
The purpose of this study is to assess the efficacy and safety of ALD403 in the prevention of migraine headache in chronic migraineurs.
- Trial name
- PROMISE 2 (NCT02974153)
- Testing
- ALD403 (Eptinezumab)
- Where
- 144 sites in United States, Belgium and 11 more
- Volunteers
- 1,121 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Migraine, Headache
Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache.
The purpose of this study is to determine whether Topiramate is effective in preventing the development of chronic daily headache among patients with episodic migraine headaches.
- Conditions
- Migraine, Headache, Classic Migraine, Common Migraine
- Trial name
- NCT00212810
- Testing
- Topiramate
- Volunteers
- 385 people
- Sponsor
- Ortho-McNeil Neurologics, Inc.
Migraine
An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention.
The purpose of this study is to assess the long-term safety and effectiveness of topiramate for the prevention of migraine headaches in adults. Topiramate has been approved to prevent migraine headaches in adults.
- Trial name
- NCT00210860
- Testing
- topiramate
- Volunteers
- 142 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Migraine Disorders
An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
A 6-month, observational, post authorization safety study for the collection and evaluation of additional safety data on topiramate as a prophylactic treatment for migraines in adult patients.
- Trial name
- NCT00297336
- Testing
- Topiramate
- Volunteers
- 80 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece