Clinical trials: Chronic Migraine Headache, open to volunteers
Migraine, Headache
Determining the Utility of a Behavioral Intervention in Chronic Migraine
This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine.
- Conditions
- Migraine, Headache, Migraine Disorders, Chronic Migraine
- Trial name
- RLB (NCT05415020)
- Testing
- Lifestyle Behavior Protocol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Chronic Migraine, Tension-type Headache
Fire Needling Plus Filiform Needling for Chronic Migraine With Comorbid Tension-Type Headache
The investigators conducted a multicenter, prospective, randomized controlled clinical study to learn whether fire needling combined with filiform needling applied to pericranial muscle tenderness areas can effectively treat…
- Trial name
- NCT07633522
- Testing
- filiform needling, fire needling combined with filiform needling
- Where
- 3 sites in China
- Volunteers
- 88 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Chronic Migraine Headache
The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine
Chronic migraine is a disabling neurovascular disorder and one of the leading causes of years lived with disability worldwide. Population-based studies report a worrying level of resistance to currently available treatments in…
- Trial name
- SIGMA (NCT07617441)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Migraine, Migraine With or Without Aura
New Methods for Evaluating Preventive Migraine Treatment
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided.
- Conditions
- Migraine, Migraine With or Without Aura, Headache Disorders, Chronic Migraine, Headache
- Trial name
- NCT07071506
- Testing
- Active drug for chronic migraine treatment.
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Chronic Migraine Headache, OnabotulinumtoxinA
Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine
Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life.
- Conditions
- Chronic Migraine Headache, OnabotulinumtoxinA, Greater Occipital Nerve Block, Combination Therapy
- Trial name
- NCT07535723
- Testing
- OnabotulinumtoxinA, Greater Occipital Nerve Block (GONB)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Chronic Migraine, Headache
Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
- Trial name
- NCT07512219
- Testing
- Greater occiptal nerve block, Pulsed radiofrequency
- Volunteers
- 70 people
- Sponsor
- Sohag University
Migraines, Chronic Pain
Mind Body Intervention for Chronic Migraine Headaches
The goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar…
- Trial name
- NCT06690060
- Testing
- Mind-Body Intervention
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
Ear Noise, Tinnitus, Noise Induced
Multimodal Therapy for Somatosensory Tinnitus
Tinnitus (ringing or buzzing in the ears) affects approximately 10-15% of the adult population and significantly reduces quality of life in many patients.
- Conditions
- Ear Noise, Tinnitus, Noise Induced, Tinnitus, Subjective, Headache Other
- Trial name
- SOMATIN (NCT07468318)
- Testing
- Multimodal physiotherapy for TMJ and Cervical spine, Combined Exercise Program (Aerobic + Resistance + Breathing), Tinnitus-Specific Psychological Support
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Migraine, Migraine With Aura
Gepant treAtments: EffectIveNess and tolERability (GAINER)
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of rimegepant as acute migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- GAINER (NCT05903027)
- Testing
- Rimegepant 75 MG Disintegrating Oral Tablet
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Myofascial Trigger Points, Chronic Migraine Headache
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Chronic Migraine
Chronic migraine is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life.
- Conditions
- Myofascial Trigger Points, Chronic Migraine Headache, Greater Occipital Nerve Block
- Trial name
- NCT07347067
- Testing
- MTrPs Injection, Greater occipital nerve block group
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Migraine Headache, Transcranial Direct Current Stimulation
TCDS for the Treatment of Chronic Migraine
Migraine affects 1 in 7 people worldwide, but for those suffering from chronic migraine there is a need for safe, effective and well tolerated treatments.
- Trial name
- NCT07214454
- Testing
- Transcranial direct current stimulation (Nettle device) 2mA stimulation for 20 minutes per day
- Volunteers
- 20 people
- Sponsor
- University College, London
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Migraine, Headache, Refractory Migraine
Occipital Nerve Stimulation in Chronic Migraine
The goal of this clinical trial is to compare two different types of occipital nerve stimulation (BurstDR (dorsal root) microdosing versus Tonic) in chronic refractory migraine.
- Trial name
- NCT07087678
- Testing
- Prodigy internal pulse generator occipital nerve stimulator
- Volunteers
- 40 people
- Sponsor
- University College, London
Chronic Daily Headache, Chronic Migraine
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal…
- Trial name
- NCT03231241
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Stanford University
Migraine, Chronic Migraine Headache
The Nordic Chronic Migraine Trial of CGRP Monoclonal Antibody and Onabotulinumtoxin A Dual Therapy Compared to CGRP mAbs Monotherapy
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound.
- Trial name
- NorMig (NCT07040813)
- Testing
- CGRP mAbs and onabotulinumtoxin A
- Where
- 6 sites in Norway
- Volunteers
- 450 people
- Sponsor
- Oslo University Hospital
Chronic Migraine, Adverse Childhood Experiences
Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences
This study aims to evaluate the effectiveness of an online Mindfulness-Based Cognitive Therapy (MBCT) program in reducing pain, stress-related symptoms, and improving functionality in adults with chronic migraine and a history of…
- Conditions
- Chronic Migraine, Adverse Childhood Experiences, Depression, Anxiety
- Trial name
- NCT07033520
- Testing
- Online Mindfulness-Based Cognitive Therapy
- Where
- Colombia
- Volunteers
- 60 people
- Sponsor
- Fundación Cardiovascular de Colombia
Chronic Headache, Migraine
Assessment of the Effectiveness of Virtual Reality as a Learning Tool for Relaxation Techniques in Reducing Pediatric Migraines and Tension Type Headache
The goal of this interventional study is to assess the efficacy of a therapeutic intervention aimed at diminishing pediatric chronic headache.
- Conditions
- Chronic Headache, Migraine, Tension Type Headache
- Trial name
- NCT06921109
- Testing
- Experimental: Relaxation training with VR, Experimental: Relaxation training without VR, No Intervention: Control group
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University of Liege
Headache (Migraine), Migraine
Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification
Patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. Healthy controls will only be asked to visit the study center for sample collection.
- Conditions
- Headache (Migraine), Migraine, Migraine Headache, Migraine with Aura
- Trial name
- FAST (NCT06674772)
- Testing
- Saliva test
- Where
- Spain
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute