Clinical trials: Chronic Mountain Sickness
Pulmonary Hypertension, Mountain Sickness
Study of the Effects of Iron Levels on the Lungs at High Altitude
The study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels.
- Trial name
- NCT00952302
- Testing
- Iron sucrose, Normal saline, Venesection
- Where
- Peru
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Measurement of Retinal Venous Pressure in Chronic Low-oxygen Environment
The hypothesis is that the pressure in the retinal veins increases from chronic lack of oxygen and leads to decreased blood flow. On the basis of high altitude mountaineering this hypothesis should be verified.
- Trial name
- NCT01771770
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
HA Residents With PVD, 6MWD Assessed at HA (2840m) vs LA (Sea Level)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT05996302
- Testing
- Relocation to sea level
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Multiple System Atrophy
High-Altitude Neurodegeneration Cohort (HANC) Study
Chronic physiological hypoxia has been implicated in the pathogenesis of multiple system atrophy (MSA), a fatal neurodegenerative disorder of unknown etiology.
- Trial name
- HANC (NCT07657520)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- West China Hospital
High Altitude Polycythemia
Treatment of High Altitude Polycythemia by Acetazolamide
The prevalence of High Altitude Polycythemia (or Chronic Mountain Sickness) is between 8 and 15% in the high altitude regions of South America. There is no pharmacological treatment available.
- Trial name
- NCT00424970
- Testing
- acetazolamide
- Where
- Peru
- Volunteers
- 55 people
- Sponsor
- Association pour la Recherche en Physiologie de l'Environnement
Hypoxia, Altitude
Treatment of Chronic Mountain Sickness
This study aims to assess the effect of two drugs for the treatment of chronic mountain sickness in highlanders.
- Trial name
- Exp5300 (NCT04251364)
- Testing
- Acetazolamide, Atorvastatin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Hypoxia, Altitude, Blood Flow Restriction
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions.
- Conditions
- Hypoxia, Altitude, Blood Flow Restriction, Resistance Training
- Trial name
- NCT06171841
- Testing
- low-intensity resistance training, high-intensity resistance training, low-intensity resistance training combined with blood flow restriction
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Chronic Respiratory Disease, Hypoxia, Altitude
Validation of a Predictive Score for HAST
Patients with chronic lung diseases travelling by plane often suffer with symptoms related to lower oxygen levels they are exposed to while flying.
- Conditions
- Chronic Respiratory Disease, Hypoxia, Altitude, COPD, ILD
- Trial name
- NCT03728595
- Testing
- Venepuncture, Spirometry, Hypoxic altitude simulation test (HAST)
- Where
- United Kingdom
- Volunteers
- 96 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Erythrocytosis, Mountain Sickness
Study of Cobalt's Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru
Chronic mountain sickness is characterized by excessive red blood cell production which causes sludging of the vascular system. This high viscosity blood causes heart failure, cognitive dysfunction, and strokes.
- Trial name
- CoCMS (NCT01187108)
- Testing
- N-acetylcysteine, Acetazolamide
- Where
- Peru
- Volunteers
- 85 people
- Sponsor
- University of Colorado, Denver
Right Heart Function, Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high…
- Conditions
- Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness
- Trial name
- NCT04915365
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
High Altitude (HA) Residents With Pulmonary Vascular Diseseases (PVD), Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) vs Sea Level (LA)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06092424
- Testing
- Relocation from HA to LA
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Zurich
Hypoxia
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment.
- Trial name
- NCT03101904
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Chronic Obstructive Pulmonary Disease, Altitude Sickness
Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate efficacy of acetazolamide in preventing overt altitude-related adverse health effects (ARAHE) in lowlanders with chronic obstructive pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Altitude Sickness, Altitude Hypoxia
- Trial name
- NCT04913389
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
High Altitude (HA) Residents With Pulmonary Vascular Diseases (PVD), 6 Minute Walk Distance (6MWD) Assessed at 2840m (HA) With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in participants with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH) who permanently live >2500m…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06003244
- Testing
- 6-minute walk distance (6MWD) test, 6-minute walk distance (6MWD) test with supplemental oxygen (3 l/min, nasal)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Mountain Sickness, Chronic
Chronic Mountain Sickness, Systemic Vascular Function
Diseases associated with chronic hypoxemia like chronic obstructive pulmonary disease (COPD) or emphysema, represent major medical and socio-economical problems and one of the leading cause of morbidity and mortality in the…
- Trial name
- CMS (NCT01182792)
- Testing
- Vitamin C and E
- Where
- 2 sites in Bolivia, Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Chronic Mountain Sickness
Erythrocytapheresis for Chronic Mountain Sickness
The study aims to explore the efficacy and safety of erythrocytapheresis in chronic mountain sickness
- Trial name
- NCT04557995
- Testing
- Erythropheresis
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Third Military Medical University
COPD
Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease Who Live at High Altitude
A clinical, prospective, randomized controlled trial to determine the effect of prescribing oxygen in a group of COPD (chronic pulmonary disease) patients with PaO2 (arterial oxygen tension) ≥50 and ≤55 mmHg who do not have…
- Trial name
- COPD-LTOT (NCT03020212)
- Testing
- Oxygen
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundación Neumologica Colombiana
Chronic Obstructive Pulmonary Disease (COPD)
Altitude Related Illness In Patients With Respiratory Disease
Randomized, placebo controlled trial evaluating efficacy of dexamethasone in preventing acute mountain sickness in lowlanders with chronic obstructive lung disease travelling from 700 m to 3200 m.
- Trial name
- NCT02450968
- Testing
- Dexamethasone
- Where
- Kyrgyzstan
- Volunteers
- 124 people
- Sponsor
- University of Zurich
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
HA Residents With PVD, SDB Assessed at HA (2840m) vs LA (Sea Level)
To study the effect of relocation from 2840m (Quito) to sea level (Pedernales) in patients with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH)…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06072417
- Testing
- Assessment without intervention at High altitude, Relocation to sea level for 2 days
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich