Clinical trials: Chronic Myocardial Ischemia
Cardiomyopathy, Heart Failure
International T1 Multicentre CMR Outcome Study
Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and…
- Conditions
- Cardiomyopathy, Heart Failure, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- T1-CMR (NCT02407197)
- Where
- 4 sites in Australia, Germany and 1 more
- Volunteers
- 1,629 people
- Sponsor
- King's College London
Acute Coronary Syndrome, Chronic Coronary Syndrome
Common Femoral Vein-to-Artery Diameter Ratio for Detection of Elevated LVEDP
This prospective cross-sectional diagnostic accuracy study enrolled patients undergoing coronary angiography and left heart catheterization at Burapha University Hospital, Thailand.
- Conditions
- Acute Coronary Syndrome, Chronic Coronary Syndrome, Heart Failure
- Trial name
- NCT07866859
- Testing
- Ultrasound Measurement of Common Femoral Vein-to-Artery Diameter Ratio
- Where
- Thailand
- Volunteers
- 105 people
- Sponsor
- Burapha University
Coronary Artery Disease, Chronic Coronary Syndrome
Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients…
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Acute Coronary Syndrome
- Trial name
- AIM-FFR (NCT07329699)
- Testing
- MPFFR or Invasive FFR
- Where
- 23 sites in South Korea
- Volunteers
- 2,100 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Effects of Icosapent Ethyl on Coronary Plaque, Inflammation, and Ventricular Remodeling
Even with standard treatments like statins, patients with coronary artery disease often face a residual risk of further heart events.
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, Coronary Artery Disease, Atherosclerosis Cardiovascular Disease
- Trial name
- NCT07641257
- Volunteers
- 420 people
- Sponsor
- Ruijin Hospital
Mental Health Impairment, Diabetes Type 2
Problem-Solving Therapy for Patients With Chronic Disease and Poor Mental Well-being in General Practice
In Denmark the vast majority of patients with chronic ischemic heart disease and/or type 2 diabetes are managed in general practice. 20% of the patients suffer from poor mental health.
- Conditions
- Mental Health Impairment, Diabetes Type 2, Ischemic Heart Disease
- Trial name
- NCT05611112
- Testing
- Problem Solving Therapy
- Where
- Denmark
- Volunteers
- 147 people
- Sponsor
- University of Aarhus
Refractory Angina Pectoris
Extracorporeal Shockwave Therapy for the Treatment of Refractory Chronic Angina Pectoris
Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with…
- Trial name
- NCT01567644
- Testing
- Cardiac Extracorporeal Shockwave Therapy generator (Cardiospec)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Medispec
Silent Stroke, Coronary Disease
Evaluation of Brain Damage Due to Coronary Angioplasty in Percutaneous Intervention Patients
This study examines the formation mechanism and patient-related factors of silent cerebral infarcts, whose importance has become increasingly recognized in patients undergoing percutaneous coronary intervention.
- Trial name
- NCT04734587
- Testing
- Blood serum Neuron-specific Enolase measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ondokuz Mayıs University
Chronic Coronary Syndrome, Acute Coronary Syndromes
Optimal LDL-C Target in High-risk Patients After PCI
Extensive evidence from epidemiological, genetic, and randomized controlled trials (RCTs) of lipid-lowering therapies has firmly established a causal relationship between low-density lipoprotein cholesterol (LDL-C) and…
- Conditions
- Chronic Coronary Syndrome, Acute Coronary Syndromes, Percutaneous Coronary Intervention, High Risk Patient
- Trial name
- REC-SAFETARGET (NCT06821711)
- Testing
- Intensive LDL-C control, Conventional LDL-C control
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease
The "CAD-Man" EXTEND Study
CAD-Man Extend is the long-term follow-up (clinical, laboratory, and computed tomography (CT) imaging) of a single-center, randomized, controlled CAD-Man trial comparing a CT-first strategy with a direct- invasive coronary…
- Trial name
- CAD-Man-EXTEND (NCT06237673)
- Testing
- CT, invasive coronary angiography (ICA)
- Where
- Germany
- Volunteers
- 318 people
- Sponsor
- Charite University, Berlin, Germany
Pulmonary Disease, Chronic Obstructive
Airflow Limitation in Cardiac Diseases in Europe
This is a cross-sectional, observational study, investigating the point prevalence of Airflow Limitation in current or former smokers with established ischemic heart disease.
- Trial name
- ALICE (NCT01485159)
- Testing
- Spirometry
- Where
- 15 sites in Belgium, France and 7 more
- Volunteers
- 3,000 people
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation, Coronary Artery Disease
Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease
This study evaluates the efficacy and safety of Edoxaban with the combination of edoxaban and antiplatelet in patients with stable CAD (coronary artery stenosis ≥50% on medical treatment or revascularized stable CAD [≥ 12 months…
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Stable Angina, Stable Chronic Angina
- Trial name
- EPIC-CAD (NCT03718559)
- Testing
- Edoxaban Monotherapy, Edoxaban plus Single Antiplatelet Agent
- Where
- 18 sites in South Korea
- Volunteers
- 1,040 people
- Sponsor
- Gi-Byoung Nam
Chronic Kidney Disease, Stable Angina
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease
Impaired renal function is associated with reduced responsiveness to clopidogrel. There are no studies which have shown a means by which to overcome platelet hyporesponsiveness in patients with chronic kidney disease (CKD).
- Trial name
- CKD (NCT01328470)
- Testing
- Clopidogrel, cilostazol
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Kyunghee University Medical Center
Heart Failure, Congestive, Coronary Arteriosclerosis
After Discharge Management of Low Income Frail Elderly
The purpose of this study is to determine whether comprehensive post-hospitalization interdisciplinary care management can be an effective care delivery model to improve outcomes in low-income frail elderly.
- Conditions
- Heart Failure, Congestive, Coronary Arteriosclerosis, Atrial Fibrillation, Cerebrovascular Accident
- Trial name
- NCT00328848
- Testing
- Behavioral
- Volunteers
- 530 people
- Sponsor
- Summa Health System
Ischemic Heart Disease
In Vivo Tracking of USPIO Labeled MSC in the Heart
To evaluate the ability to trace iron oxide-labeled mesenchymal stromal cells with magnetic resonance imaging (MRI) after NOGA-guided injection therapy into the myocardium in patients with ischemic heart disease.
- Trial name
- USPIO-MSC (NCT03651791)
- Testing
- USPIO labeled MSC injection
- Volunteers
- 5 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Angina Pectoris
Change in Exercise Capacity as Measured by Peak Oxygen Uptake After CTO PCI
The purpose of this project is to objectively assess the change (improvement) in exercise capacity in patients undergoing routine percutaneous coronary intervention (PCI) for chronic total occlusion (CTO)
- Trial name
- EXERTION (NCT02499666)
- Testing
- Percutaneous Coronary Intervention, Coronary stent, Clopidogrel
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Chronic Coronary Syndrome, Chronic Coronary Total Occlusion
Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease
This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.
- Conditions
- Chronic Coronary Syndrome, Chronic Coronary Total Occlusion, Coronary Arterial Disease (CAD), Stable Chronic Angina
- Trial name
- BNP-CAD (NCT07013344)
- Testing
- BNP
- Where
- 2 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Ospedale San Raffaele
COPD, Coronary Artery Disease
The Impact of Post Discharge One-Time Home Visit: Bridging the Gap Between Hospital and Home.
A single post-hospital discharge home visit by a geriatric nurse practitioner or geriatric fellow can bridge the gap and ease the transition for elderly frail patients returning home after hospital admission.
- Conditions
- COPD, Coronary Artery Disease, Diabetes Mellitus, Stroke
- Trial name
- NCT00276367
- Sponsor
- Maimonides Medical Center
Platelet Aggregation, Spontaneous, Coronary Artery Disease
Effect of Low Dose of Colchicine on Platelet Reactivity
Inflammation plays an important role in atherosclerosis and the occurrence of ischemic events. Statins, in addition to their lipid-lowering effect, have also documented anti-inflammatory effect that may partly explain their…
- Trial name
- NCT05956145
- Testing
- Colchicine 0.5 MG
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Hypertension
Clinical Trial to Evaluate Pharmacokinetic Profiles and Safety Between CKD-385 and D935 in Healthy Volunteers
A randomized, open-label, fed, single dose, crossover study to evaluate the pharmacokinetic profiles and safety of CKD-385 in healthy volunteers
- Trial name
- NCT03748212
- Testing
- D935 Cap. 1T, CKD-385 Tab. 1T
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Coronary Artery Disease, Valvular Heart Disease
Prehabilitation for Patients Undergoing Elective Cardiac Surgery
The objective of this clinical trial is to develop a novel rehabilitation model that, through the PRECICA program, will help to reduce perioperative and postoperative complications in the care process prior to planned cardiac…
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Chronic Thromboembolic Pulmonary Hypertension, Aortic Diseases
- Trial name
- PRECICA (NCT07704086)
- Testing
- Physical exercise, Educational program and respiration physiotherapy
- Where
- 2 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Hospital Universitario 12 de Octubre