Clinical trials: Chronic Myocardial Ischemia
Asthma, Chronic Obstructive Pulmonary Disease
Usability and Acceptability Study of the P-STEP Mobile Application
Assess the usability and acceptance of the P-STEP app, through allowing participants with specific chronic conditions to pilot the app for 12-weeks.
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Coronary Heart Disease
- Trial name
- NCT05830318
- Testing
- P-STEP Mobile Application
- Where
- United Kingdom
- Volunteers
- 178 people
- Sponsor
- University of Leicester
Heart Failure, Coronary Artery Disease
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure
According to modern concepts, mitochondrial dysfunction may be the fundamental basis for the development and progression of CHF, including in patients undergoing myocardial revascularization.
- Trial name
- MITOCH-HF (NCT05770349)
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Ischemic Heart Disease, Heart Failure
Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance
In 2005, more then one-third of Canadians were burdened with one or more chronic diseases. Patients with one chronic disease often have, or are at risk for, another chronic disease.
- Conditions
- Ischemic Heart Disease, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- iCDM (NCT01342263)
- Testing
- iCDM
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- Simon Fraser University
Coronary Atherosclerosis, Endothelial Dysfunction
Assessment of Coronary Plaque Composition Using Optical Coherence Tomography
The investigator's hypothesis is that local activation of the endogenous Lp-PLA2 plays an integral role in early atherosclerosis, and contributes to the mechanism of coronary endothelial dysfunction and to the structural and…
- Conditions
- Coronary Atherosclerosis, Endothelial Dysfunction, Coronary Small Vessel Disease
- Trial name
- NCT01642173
- Testing
- Optical Coherence Tomography (C7 XR Dragonfly )
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Heart Failure
Efficacy and Safety of Jia Shen Tablets in Chronic Heart Failure
Evaluate the efficacy and safety of Jia Shen Tablets in patients with Chronic Heart Failure.
- Trial name
- NCT06669169
- Testing
- Low dose Jia Shen Tablet, High dose Jia Shen Tablet
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Coronary Heart Disease
Recovery of Left Ventricular Function in Chronic Total Occluded Coronary Arteries
The study is a randomised comparison of recanalisation of chronic occluded coronary arteries with implantation of Sirolimus eluting stents and medical therapy.
- Trial name
- REVASC (NCT01924962)
- Testing
- revascularisation
- Where
- Germany
- Volunteers
- 205 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Angina Pectoris
Phase II Multi-Center Study of T89 to Treat Chronic Stable Angina
The purpose of this study is to determine the anti-angina effect and dose response of T89, a 2-herb botanical drug product, in patients with chronic stable angina pectoris in the United States.
- Trial name
- T89 phase 2 (NCT00797953)
- Testing
- T89
- Where
- 15 sites in United States
- Volunteers
- 124 people
- Sponsor
- Tasly Pharmaceuticals, Inc.
Chronic Stable Angina, Dyspnea
A Randomized Multicentre Trial to Evaluate the Utilization of Revascularization or Optimal Medical Therapy for the Treatment of Chronic Total Coronary Occlusions
CTOs are common among patients with angina, and are detected in around 20% of patients undergoing coronary angiography. Treatment of CTO has been found to constitute only 7% of PCI practice on average.
- Conditions
- Chronic Stable Angina, Dyspnea, Coronary Occlusion
- Trial name
- EuroCTO (NCT01760083)
- Testing
- Biolimus-eluting stent implantation
- Where
- 19 sites in France, Germany and 4 more
- Volunteers
- 450 people
- Sponsor
- Euro CTO Club
Platelet Aggregation, Adenosine
Platelet Aggregation in Patients With Coronary Artery Disease and Kidney Dysfunction Taking Clopidogrel or Ticagrelor
About 35% of patients hospitalized with Acute Coronary Syndromes (ACS) have some degree of renal dysfunction. Chronic kidney disease (CKD) is not only associated to worse prognosis in ACS patients, but leads also to an increased…
- Conditions
- Platelet Aggregation, Adenosine, Coronary Artery Disease, Kidney Dysfunction
- Trial name
- NCT03039205
- Testing
- Clopidogrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Chronic Kidney Disease, Multivessel Coronary Artery Disease
Randomized Comparison of xiEnce and visioN Coronary Stents in the sAme muLtivessel Patient With Chronic kiDnEy diSease
Percutaneous coronary intervention (PCI) with bare metal stent (BMS) in patients with renal insufficiency has shown unsatisfactory results.
- Trial name
- RENAL-DES (NCT00818792)
- Testing
- Coronary stent
- Where
- 2 sites in Italy
- Volunteers
- 215 people
- Sponsor
- European Hospital
Coronary Arterial Disease (CAD), Coronary Calcification
Orbital Atherectomy vs Intravascular Lithotripsy for the Treatment of Calcified Coronary Nodules (ORBIT-SHOCK).
The ORBIT-SHOCK pilot study is a multicenter, prospective, randomized clinical trial initiated by investigators. It will include patients diagnosed with atherosclerotic coronary artery disease presenting calcified nodules (CN)…
- Conditions
- Coronary Arterial Disease (CAD), Coronary Calcification, Coronary Calcified Nodules, Orbital Atherectomy
- Trial name
- ORBIT-SHOCK (NCT06736665)
- Testing
- Orbital atherectomy, Intravascular lithotripsy, Optical Coherence Tomography (OCT)
- Where
- 6 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Spanish Society of Cardiology
Acute Myocardial Infarction, Unstable Angina
PERcutaneouS Coronary intErventions in Patients Treated With Oral Anticoagulant Therapy
Approximately 5 to 8% of patients undergoing percutaneous coronary interventions requires chronic anticoagulant therapy due to atrial fibrillation or other clinical entities.
- Conditions
- Acute Myocardial Infarction, Unstable Angina, Chronic Stable Angina
- Trial name
- PERSEO (NCT03392948)
- Where
- 10 sites in Italy
- Volunteers
- 1,080 people
- Sponsor
- Italian Society of Invasive Cardiology
Myocardial Infarction, Hypertension
Reducing Blood Pressure in Patients With High Cardiovascular Risk
BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services healthcare system.
- Conditions
- Myocardial Infarction, Hypertension, Stroke
- Trial name
- BP-REACH (NCT05937685)
- Testing
- BP REACH Intervention
- Where
- 4 sites in United States
- Volunteers
- 546 people
- Sponsor
- University of Southern California