Clinical trials: Chronic Nephropathy
Patients With Type 2 Diabetes
Use of Clinical-trials and Simulation Models to Estimate Cost-effectiveness of Non-steroidal Mineralocorticoid Antagonists, RASi and SGLT2i as Triple Therapy With Type 2 Diabetes and Chronic Kidney Disease
To evaluate triple therapy with nsMRA, RASi and SGLT2i on albuminuria in individuals with T2D and CKD
- Trial name
- RAiSiN (NCT06727409)
- Testing
- Finerenone
- Where
- Hong Kong
- Volunteers
- 82 people
- Sponsor
- Chinese University of Hong Kong
Influenza, End Stage Renal Failure
Immunogenicity of a Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Undergoing Hemodialysis
During the 2013-2014 influenza season, CKD patients undergoing HD participated in the study. The patients were randomized into two groups (MF59-adjuvanted vaccine group or non-adjuvanted vaccine group) and were immunized with the…
- Conditions
- Influenza, End Stage Renal Failure, Chronic Kidney Disease
- Trial name
- NCT02686398
- Testing
- Fluad, Agrippal
- Volunteers
- 174 people
- Sponsor
- Korea University Guro Hospital
Kidney Failure, Chronic, Renal Dialysis
Cardiovascular Risk Comparison Between Expanded Hemodialysis Using Theranova and On-line Hemodiafiltration
Theranova is a novel medium cut-off (MCO) dialyzer. Previous studies identified that theranova dialyzer had superior performance on middle molecule removal to conventional hemodialysis (HD) and hemodiafiltration (HDF).
- Trial name
- CARTOON (NCT03448887)
- Testing
- Theranova, Online hemodiafiltration
- Where
- 4 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Hypotension and Shock, Hemodialysis
Pleth Variability Index for Predicting Low Blood Pressure During Maintenance Hemodialysis
What is this study about? We are studying whether the Pleth Variability Index (PVI)-a simple, non-invasive measurement from a pulse oximeter-can help predict low blood pressure (hypotension) during routine maintenance…
- Conditions
- Hypotension and Shock, Hemodialysis, End-Stage Renal Disease Requiring Haemodialysis, Intradialytic Hypotension
- Trial name
- PVI-HD (NCT07022847)
- Testing
- Non-invasive Monitoring
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Renal Insufficiency, Chronic
Effects of Fasting Mimetic Diet on Nephropatic Patients
Fasting mimetic diet (FMD) showed positive effects on cardiovascular risks. Purpose of the trial is to evaluate FMD effects on patients affected by chronic kidney disease (CKD), through the stimulation of kidney stem cells and…
- Trial name
- NCT04490252
- Testing
- Fasting mimetic diet
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- University of Roma La Sapienza
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of ixabepilone in treating young…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00030108
- Testing
- ixabepilone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
End Stage Renal Disease
Trial of Adoptive Immunotherapy With TRACT to Prevent Rejection in Living Donor Kidney Transplant Recipients
Regulatory CD4+CD25+ T cells (Treg) derived from the thymus and/or peripheral tissues have been demonstrated to broadly control T cell reactivity (14).
- Trial name
- TRACT (NCT02145325)
- Testing
- Expanded Tregs
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Chronic Kidney Disease
Phase 1a Study Assessing Safety, Tolerability, Pharmacokinetics, and Immunogenicity of PMG1016
This study is a first-in-human (FIH), randomized, double-blind, placebo-controlled study of PMG1016 in healthy adult participants.
- Trial name
- NCT07615985
- Testing
- PMG1016 Dose 1, PMG1016 Dose 2, PMG1016 Dose 3
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pulmongene Ltd.
Fatigue, End Stage Kidney Disease
The Energy Conservation Education Intervention
Fatigue is the most common symptom reported by 70 - 85 % of people with end-stage kidney disease (ESKD) receiving haemodialysis (HD).
- Conditions
- Fatigue, End Stage Kidney Disease, Quality of Life
- Trial name
- NCT04360408
- Testing
- Energy conservation education intervention for people with end-stage kidney disease receiving hemodialysis
- Volunteers
- 126 people
- Sponsor
- Queensland University of Technology
Patients With Severe Chronic Kidney Disease Being Evaluated With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson
Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging
The routine administration of 75 mg of intravenous aminophylline in patients with severe chronic kidney disease undergoing a nuclear stress test with regadenoson (Lexiscan®) can reduce or eliminate the incidence of diarrhea and…
- Trial name
- ASSUAGE-CKD (NCT01336140)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Chronic Kidney Disease, Anemia
Effects Of Darbepoetin On Vascular Repair Mechanisms In Kidney Disease The DARBEPC Study
Humans have cells in their blood stream called endothelial progenitor cells or EPCs. These are thought to be important in keeping blood vessels healthy. People with chronic kidney disease (CKD) have low numbers of these cells.
- Trial name
- NCT00396123
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Chronic Kidney Disease, Hyperuricemia
Compare the Renal Protective Effects of Febuxostat and Benzbromarone
The purpose of this study is to determine whether febuxostat and benzbromarone could protect renal function, and which one could be better.
- Conditions
- Chronic Kidney Disease, Hyperuricemia, Abnormal Renal Function
- Trial name
- NCT02338323
- Testing
- Febuxostat, Benzbromarone
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai 10th People's Hospital
Chronic Kidney Disease (CKD)
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness.
- Trial name
- EMPHASIS (NCT06607913)
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Proteinuria, Diabetic Nephropathy
Effect of Renin Angiotensin System Blockade on the Fas Antigen (CD95) and Asymmetric Dimethylarginine (ADMA) Levels in Type-2 Diabetic Patients With Proteinuria
In recent years, diabetic nephropathy, which may lead to dialysis treatment, is the most prevalent underlying disease of people in developed countries.
- Conditions
- Proteinuria, Diabetic Nephropathy, Chronic Kidney Disease
- Trial name
- NCT00893425
- Testing
- ramipril
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Chronic Kidney Diseases
SOP's for CKD-MBD-Biomarkers
CKD-MBD (Chronic Kidney Disease - Mineral and Bone Disorder) is an extensive disease and includes dysfunction of the mineral metabolism, the bone metabolism and cardiovascular diseases in the context of renal insufficiency.
- Trial name
- NCT02708368
- Testing
- blood withdrawal
- Where
- 2 sites in Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Heart Failure
Evaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney Disease
The purpose of this study was to evaluate the feasibility of individualized titration of patiromer according to serum potassium.
- Trial name
- NCT01130597
- Testing
- patiromer, spironolactone
- Where
- 13 sites in Georgia, Slovenia
- Volunteers
- 63 people
- Sponsor
- Relypsa, Inc.
CKD (Chronic Kidney Disease) Stage 5D, Hemodialysis
Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis
This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis.
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Hemodialysis, Pruritis
- Trial name
- NCT06671535
- Testing
- Polymethylmethacrylate membrane, polysulfone membranes
- Where
- Russia
- Volunteers
- 62 people
- Sponsor
- Saint Petersburg State University, Russia
Renal Insufficiency, Chronic, Nephrotic Syndrome
Rituximab Combined With MSCs in the Treatment of PNS (3-4 Stage of CKD)
Primary nephrotic syndrome(PNS) is a group of clinical symptoms caused by a variety of factors, including immune,environmental, genetic, et al.
- Trial name
- CKD (NCT02966717)
- Testing
- Rituximab, conventional therapy, Mesenchymal stem cells
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Zhujiang Hospital
Chronic Kidney Disease
Trial of Pirfenidone to Prevent Progression in Chronic Kidney Disease
Kidney disease is a global health problem, affecting more than 10% of the world's population and more than half of adults over 70 years of age in the United States.
- Trial name
- TOP-CKD (NCT04258397)
- Testing
- Pirfenidone
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Veterans Medical Research Foundation
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
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