Clinical trials: Chronic Obstr Lung Disease
Respiratory Failure With Hypercapnia
Extra-Corporeal Carbon Dioxide Removal in Exacerbations of Chronic Obstructive Pulmonary Disease
Around 20% of the patients requiring hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) develop hypercapnia, which is associated with an increased risk of death.
- Trial name
- NCT03990155
- Testing
- HFNCOT+ECCO2R
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) affects up to 14 million people and is among the top five leading causes of death worldwide.
- Trial name
- COPD-LT (NCT02774226)
- Testing
- Tetrahydrobiopterin (BH4), Antioxidant Cocktail
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Augusta University
COPD
Study of the Effects of Education on Patients With Chronic Obstructive Pulmonary Disease
The investigators hypothesize that education will improve exercise capacity, symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01633697
- Testing
- Pranayama, Education alone
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Vermont
COPD
Assessing Exercise Capacity After PulseHaler™ Treatment in GOLD II-IV COPD Patients
Prospective, sham controlled, interventional study to evaluate the extent to which PulseHaler improves the functional status of Chronic Obstructive Lung Disease (GOLD) II-IV Chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT04236076
- Testing
- PulseHaler
- Volunteers
- 104 people
- Sponsor
- Respinova LTD
Lung Diseases, Lung Diseases, Obstructive
Lung Health Study (LHS) I and III
In the Lung Health Study I, to determine the effects of Special Care, compared to Usual Care, on rate of decline in pulmonary function in a group of cigarette smokers identified as having mild abnormalities in pulmonary function.
- Conditions
- Lung Diseases, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00000568
- Testing
- smoking cessation, ipratropium
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease, COPD
Cardiac Limitations in Chronic Obstructive Pulmonary Disease: Benefits of Bronchodilation
This study is being done to examine the influence of Tiotropium (good or bad) on heart function at rest and during exercise in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00578968
- Testing
- Tiotropium
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Respiratory Failure, Neuromuscular Disease
Ventilator Monitoring in Early Exacerbation Detection
The aim of this study is to determine whether respiratory disease exacerbations (a sudden worsening of symptoms) can be predicted by variables that are monitored by non-invasive ventilators (small machines that assist breathing)…
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01644162
- Testing
- iVAPS ventilation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- ResMed
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD
Laying the Foundation for Building a Resilient KPNC Community in the Face of Worsening Air Quality Due to Wildfire Smoke
The overarching goal of this project is to conduct a pilot intervention in high-risk Kaiser Permanente Northern California patients with chronic obstructive pulmonary disease to mitigate their exposure to poor air quality and…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD, Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- DS-F (NCT07118189)
- Testing
- N95 masks and indoor air cleaner
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Chronic Obstructive Pulmonary Disease (COPD)
A Prospective, Cohort Study of Hyperpolarized 3He MRI in Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the MRI characteristics of Chronic Obstructive Pulmonary Disease subjects both at baseline and yearly for a period of 5 years, and to correlate these biomarkers with pulmonary function…
- Trial name
- NCT02734368
- Testing
- Hyperpolarized Helium-3
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation
Trial to Study Intubation Rates of Non-invasive Ventilation Using Pressure Support Ventilation (PSV) Versus Adaptive Support Ventilation (ASV) Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The clinical course of chronic obstructive pulmonary disease (COPD) is associated with recurrent episodes of exacerbation that results in respiratory failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation, Adaptive Support Ventilation
- Trial name
- PSV vs ASV for (NCT02877524)
- Testing
- Adaptive support ventilation, Pressure support ventilation
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COPD, Emphysema
Evaluation of Immunological, Microbiological and Metabolomic Profiles in COPD
COPD is a significant health problem worldwide. It affects more than 10% of patients over the age of 40. According to the World Health Organization, it is the third most common cause of death among adults in the world, and the…
- Conditions
- COPD, Emphysema, Chronic Bronchitis, Smoking
- Trial name
- NCT06826560
- Where
- Poland
- Volunteers
- 92 people
- Sponsor
- Medical University of Warsaw
Pulmonary Disease, Chronic Obstructive (COPD)
Real-world, 52-week Prospective Study to Capture the Reasons for Switch to Triple Combination Therapy, Assess the Clinical and Patient Reported Outcomes in Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece
Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive respiratory condition characterized by irreversible airflow limitation.
- Trial name
- TRIAENA (NCT05915182)
- Testing
- Budesonide Glycopyrronium bromide Formoterol fumarate pressurized Metered Dose Inhaler
- Where
- 15 sites in Greece
- Volunteers
- 212 people
- Sponsor
- AstraZeneca
COPD (Chronic Obstructive Pulmonary Disease)
Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators
The purpose of this study is to compare the effectiveness of inhaled bronchodilators delivered via nebulizers vs. dry powder inhalers (DPIs) in symptomatic participants with Chronic Obstructive Pulmonary Disease (COPD) who have…
- Trial name
- NCT07133880
- Testing
- umeclidinium 62.5 µg and vilanterol 25 µg, Revefenacin 175 µg, Formoterol 20 µg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Tennessee Graduate School of Medicine
COPD, Lung Cancer
Prevalence of COPD in Our Lung Cancer Population, Compared to Controls
This study will investigate the prevalence of chronic obstructive pulmonary disease (COPD) in patients who are newly diagnosed with lung cancer and compare it to the prevalence of COPD in controls recruited from a smoking…
- Conditions
- COPD, Lung Cancer, Smoking
- Trial name
- NCT02603627
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Russian Current and Expiratory Muscle Training in COPD Patients
Respiratory muscles are essential to alveolar ventilation. In COPD, these muscles work against increased mechanical loads due to airflow limitation and geometrical changes of the thorax derived from pulmonary hyperinflation.
- Trial name
- NCT04704479
- Testing
- Russian current, EMT
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Obstructive Airway Disease
Pulmonary Disease in a Psychiatric Inpatient Population
Purpose: Patients with mental health disorders have a reduced life expectancy, compared to the general population. The shorter life expectancy is caused by natural and unnatural death.
- Trial name
- NCT01823627
- Testing
- Spirometry with reversibility test
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Psykiatrien Syd
Postoperative Pain, Satisfaction with Care
Thoracic Spinal Versus Thoracic Epidural Anesthesia for Patients with Chronic Obstructive Pulmonary Disease Undergoing Supine Percutaneous Nephrolithotomy for Management of Renal Stones.
Owing to the elevated risk of perioperative comorbidities, chronic obstructive and restrictive pulmonary disorders can be a challenging task for the anesthetist.
- Trial name
- NCT06663488
- Testing
- Thoracic epidural anesthesia, Thoracic spinal anesthesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Chronic Obstructive Pulmonary Disease
Analysis With Clusters of QUAntitative Tomodensitometric Vascular, bronchIal and Parenchymal Pulmonary Parameters for COPD Patients
Chronic obstructive pulmonary disease (COPD) is caused by tobacco consumption. The goal is to characterize on clinical and radiological data, using computed tomography, this illness in order to improve diagnostic and be able to…
- Trial name
- ACQUAVIP (NCT03337854)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Bordeaux
Chronic Obstructive Pulmonary Disease
Using Clinical Prediction Models to Improve Treatment for Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease of the lungs that affects more than 2.5 million Canadians. Patients with COPD experience episodes of lung attacks (or exacerbations).
- Trial name
- NCT05309356
- Testing
- ACCEPT Decision Intervention, Comparator
- Where
- 2 sites in Canada
- Volunteers
- 1,130 people
- Sponsor
- University of British Columbia
COPD (Chronic Obstructive Pulmonary Disease)
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative
The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted will still derive symptomatic benefit from…
- Trial name
- RETHINC (NCT02867761)
- Testing
- Indacaterol/Glycopyrrolate
- Where
- 16 sites in United States
- Volunteers
- 780 people
- Sponsor
- University of Michigan
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