Clinical trials: Chronic Obstr Lung Disease
COPD
Serum Surfactant Protein-D as Predictor of Disease Severity in Hospitalized COPD Patients
evaluation of the serum levels of surfactant protein-D (SP-D), C-reactive protein (CRP), fibrinogen, and peripheral blood neutrophilic and eosinophilic counts in patients with COPD correlation of these biomarkers with clinical…
- Trial name
- NCT07154953
- Testing
- Serum Surfactant Protein-D
- Volunteers
- 75 people
- Sponsor
- Assiut University
Chronic Obstructive Airways Disease Exacerbated, Critical Care
Survival After Failed First-line Non-invasive Ventilation in Acute on Chronic Obstructive Pulmonary Disease
Observational cohort study of mid-to-long term survival of patients with acute on chronic obstructive pulmonary disease, analyzed per type of ventilation support provided during first 24 hours in intensive care.
- Trial name
- NCT03011853
- Testing
- Non-invasive and/or invasive mechanical ventilation
- Where
- Sweden
- Volunteers
- 7,900 people
- Sponsor
- Swedish Intensive Care Registry
COPD
Efficacy and Safety of Two Doses of Formoterol Fumarate MDI (PT005) in Patients With Stable Chronic Obstructive Pulmonary Disease (COPD), Compared to Foradil® Aerolizer® as an Active Control
The purpose of this study is to evaluate the safety and efficacy of inhaled formoterol fumarate (7.2 and 9.6 µg ex-actuator) compared to placebo and Foradil Aerolizer in patients with moderate to very severe chronic obstructive…
- Trial name
- NCT01043601
- Testing
- Inhaled PT005, Formoterol Fumarate 12 µg (Foradil Aerolizer)
- Where
- United States
- Sponsor
- Pearl Therapeutics, Inc.
Chronic Obstructive Lung Disease
Effect of Tadalafil in Chronic Obstructive Lung Disease Patients Suffering From Secondary Pulmonary Hypertension
Tadalafil may lower the pulmonary artery pressure in patients with Chronic Obstructive Lung Disease and secondary pulmonary hypertension and thereby improve patients quality of life.
- Trial name
- NCT00506701
- Testing
- Tadalafil
- Where
- Denmark
- Sponsor
- Herlev Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Improving Medication Management in COPD
A pilot trial to examine feasibility of a pharmacist-led intervention for patients with COPD (Chronic Obstructive Pulmonary Disease) and multimorbidity to improve medication safety and reduce dyspnea.
- Trial name
- NCT07453719
- Testing
- Pharmacist-led Medication Management Intervention
- Volunteers
- 92 people
- Sponsor
- Duke University
Chronic Obstructive Airway Disease
Continuous Versus Interval Walking Training in Patients With COPD - a Pilot Study
This study will investigate the effects of interval walking training versus continuous walking training in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT02209207
- Testing
- Treadmill, walking training
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Obstructive Pulmonary Disease
A Study of CM512 in Subjects With Moderate-to-Severe Chronic Obstructive Pulmonary Disease
A Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase II Study to Explore the Efficacy and Safety of CM512 Injection in Adults with Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT06980142
- Testing
- CM512
- Volunteers
- 204 people
- Sponsor
- Keymed Biosciences Co.Ltd
Pulmonary Disease, Chronic Obstructive
Inhaled Long-acting Bronchodilators With or Without Inhaled Glucocorticosteroids for Preventing Hospitalizations and Death in Elderly Patients With Chronic Obstructive Pulmonary Disease
This will be a phase IV, open label, multicenter, randomized pragmatic study in frail elderly patients with COPD. Participants will be treated with either inhaled LABD alone or LABD combined with inhaled glucocorticosteroids.
- Trial name
- NCT03662711
- Testing
- Bronchodilator Agents
- Where
- 39 sites in Italy
- Volunteers
- 843 people
- Sponsor
- Università degli Studi di Ferrara
Patient Participation
Role of MSCT of Chest in Differentiation Between COPD Patients According to Their Smoking Status
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality all over the world. Smoking is considered as an important risk factor, but other risk factors are present.
- Trial name
- NCT05475977
- Testing
- MSCT chest
- Volunteers
- 90 people
- Sponsor
- Somaia Ahmad AbdAllah Ahmad
Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Effects of Nocturnal Non-invasive Ventilation on Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease
It has been shown, that in patients with very severe chronic obstructive pulmonary disease (COPD) the additional use of non-invasive ventilation during pulmonary rehabilitation (PR) may enhance the benefits of PR.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, Non-invasive Ventilation, Energy Expenditure
- Trial name
- NCT01961245
- Testing
- nocturnal non-invasive ventilation
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Schön Klinik Berchtesgadener Land
Pulmonary Disease, Chronic Obstructive
Study To Evaluate The Efficacy And Safety Of PH-797804 For 12 Weeks In Adults With Moderate To Severe Chronic Obstructive Pulmonary Disease (COPD) On A Background Of Tiotropium Bromide
PH-797804 is an oral anti-inflammatory drug that may reduce the inflammation that is associated with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT01543919
- Testing
- PH-797804
- Where
- 132 sites in United States, Argentina and 12 more
- Volunteers
- 730 people
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease, Respiratory Disease
A Wireless Bed Sensor for Monitoring Coughs
Aging of the population is dramatically increasing the number of hospitalized patients, with the consequent challenges of limited medical personnel and resources in hospitals.
- Trial name
- "MoniToux" (NCT03177694)
- Testing
- Wireless bed sensor
- Volunteers
- 20 people
- Sponsor
- Ligue Pulmonaire Neuchâteloise
Severe Emphysema
A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema
To compare the efficacy and safety of subsegmental treatment and segmental treatment with InterVapor in patients with severe emphysema
- Trial name
- BTVA (NCT06152107)
- Testing
- BTVA treatment plus optimal medical therapy (GOLD guidelines)
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Patient Education in Patients With Chronic Obstructive Pulmonary Disease (COPD) - Effect and Costs
The aim of this study is to determine the long term effect of a self-help group in a patient education program for patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00705302
- Testing
- Group training with self-help group, Group training
- Where
- Norway
- Volunteers
- 88 people
- Sponsor
- Norwegian University of Science and Technology
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Inspiratory Muscle Activation Pattern and Training Efficacy in Patients With Chronic Obstructive Pulmonary Disease After Acute Exacerbation
The purpose of this study is to assess the activation patterns of diaphragm and sternocleidomastoid (SCM) muscle during different loaded inspiratory muscle performance in patients with COPD after acute exacerbation.
- Trial name
- NCT04316312
- Testing
- Threshold inspiratory muscle trainer
- Where
- Taiwan
- Volunteers
- 1 people
- Sponsor
- National Taiwan University Hospital
Idiopathic Pulmonary Fibrosis, Chronic Obstructive Pulmonary Disease
Coping Strategies Within Pulmonary Rehabilitation in Patients With IPF and COPD
The aim of this prospective observational trial is to evaluate the influence of Coping strategies on pulmonary rehabilitation outcomes like 6-minute walk distance and Quality of life.
- Trial name
- NCT04257630
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Schön Klinik Berchtesgadener Land
COPD, Healthy Volunteers
Airvo 3 Respiratory Rate Validation Study
This is a clinical performance testing to validate the accuracy of the Airvo 3 device with respiratory rate algorithm manufactured by Fisher \& Paykel Healthcare for continuous respiratory rate monitoring.
- Trial name
- NCT06329609
- Testing
- Airvo 3 with respiratory rate algorithm
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Chronic Obstructive Pulmonary Disease
A Safety and Efficacy Study of Symbicort Turbuhaler Compared With Standard Chronic Obstructive Pulmonary Disease (COPD) Treatment in Japan
The purpose of this study is to evaluate the safety and efficacy of Symbicort Turbuhaler compared to standard COPD treatment during one year in Japanese patients with COPD.
- Trial name
- NCT01070784
- Testing
- Symbicort Turbuhaler (Budesonide/formoterol), Drug: any available COPD treatment; investigator to decide
- Where
- 17 sites in Japan
- Volunteers
- 328 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
A Randomised, Double-blind, Crossover Study of Ba679BR Respimat in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this trial is to compare the efficacy and the safety of Ba 679 BR Respimat 5 ug once daily to tiotropium inhalation capsule 18 ug (Spiriva inhalation capsule) in a crossover study of 4-week treatment periods in…
- Trial name
- NCT00292448
- Testing
- Ba 679 BR Respimat, Tiotropium (Spiriva) inhalation capsule 18 ug
- Where
- 27 sites in Japan
- Volunteers
- 157 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease, Chronic Obstructive
Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This is a multicenter, prospective, randomized, double-blind, placebo-controlled trial that will enroll 1028 patients with at least moderately severe COPD over a three year period and follow them at regular intervals for one…
- Trial name
- NCT02587351
- Testing
- Metoprolol succinate
- Where
- 27 sites in United States
- Volunteers
- 532 people
- Sponsor
- University of Minnesota
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