Clinical trials: Chronic Obstruct Airways Disease
COPD, Sleep
Sleeping Position Study in COPD Patients
Background: Chronic obstructive pulmonary disease (COPD) is a common chronic disease characterized by persistent respiratory symptoms and airflow restriction, due to airway and/ or alveolar abnormalities usually caused by…
- Trial name
- NCT04963205
- Testing
- Adjustable bed backrest, Standard bed
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Lowie Vanfleteren
COPD, Pulmonary Hypertension
Study of Sildenafil Effects in Combination With Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Associated Pulmonary Hypertension
Sildenafil is a phosphodiesterase-5 inhibitor that has been approved for the treatment of pulmonary arterial hypertension with orphan drug designation. Sildenafil modulates the nitric oxide (NO) pathway in the vessel wall.
- Trial name
- SIL-COPD-02 (NCT01055405)
- Testing
- Sildenafil
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Hospital Clinic of Barcelona
Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Study to Evaluate the Pharmacokinetic Characteristics, Safety, Tolerability, and Preliminary Efficacy of 9MW1911 in Patients With Chronic Obstructive Pulmonary Disease (COPD).
The study will evaluate the pharmacokinetic characteristics, safety, tolerability, and preliminary efficacy of 9MW1911 in combination with standard of care COPD maintenance therapy in patients with moderate to severe COPD.
- Trial name
- NCT06175351
- Testing
- 9MW1911
- Where
- 22 sites in China
- Volunteers
- 80 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Chronic Obstructive Pulmonary Disease
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation.
- Trial name
- NCT03331302
- Testing
- Hyperpolarized Xenon-129 MRI (Experimental), Radioactive Xenon-133 scintigraphy (Active Comparator)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms…
- Trial name
- IMAS (NCT00974805)
- Testing
- Seretide 500 Accuhaler
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Southampton
COPD Exacerbation, Smoking, Tobacco
The Role of Congenital Mucosal Immune System in the Airways of Patients With Chronic Obstructive Pulmonary Disease
The purpose of the study is to explore the role of congenital mucosal immune system in the airways of patients with COPD including the impact of ILCs (Innate lymphoid cells) on metabolism of epithelial cells.During the research…
- Trial name
- NCT04061122
- Testing
- airway epithelial smear test
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Lodz
Chronic Obstructive Pulmonary Disease (COPD)
The Impact of Psychosocial Interventions in Patients with COPD
Chronic Obstructive Pulmonary Disease (COPD) is one of the most common exacerbating, non-communicable diseases. It is the third leading cause of death worldwide, causing 3.23 million deaths in 2019.
- Trial name
- NCT06599177
- Testing
- Informational leaflet
- Where
- Greece
- Volunteers
- 160 people
- Sponsor
- University of Crete
Chronic Obstructive Pulmonary Disease (COPD)
Stepping up to Health - for Veterans With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to assess the efficacy of an internet-mediated pedometer based intervention that is designed to increase walking and improve function among veterans with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01102777
- Testing
- automated internet-mediated walking program, Usual Care
- Where
- United States
- Volunteers
- 307 people
- Sponsor
- VA Office of Research and Development
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To establish and confirm the safety and clinical utility of BTVA applied unilaterally for lung volume reduction in patients with upper lobe predominate heterogeneous severe emphysema.
- Trial name
- BTVA (NCT01102712)
- Testing
- BTVA System
- Where
- 10 sites in Australia, Austria and 2 more
- Volunteers
- 34 people
- Sponsor
- Uptake Medical Corp
Chronic Obstructive Pulmonary Disease (COPD)
A Safety, Pharmacokinetic and Pharmacodynamic Study of PUR0200 in COPD Patients
The purpose of this study is to assess the safety and tolerability of PUR0200. In addition, the study will look at the blood levels of different doses of PUR0200 and their affect on lung function in COPD patients.
- Trial name
- NCT01921712
- Testing
- PUR0200, Active comparator
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- Pulmatrix Inc.
Chronic Obstructive Pulmonary Disease (COPD)
Change in Patient-repOrted Outcomes in COPD Patients Newly Initiated on TRIXEO AEROSPHERE in Real worlD
The purpose of this study is to describe patients' clinical and self-reported outcomes of treatment with budesonide / glycopyrronium / formoterol Metered dose inhaler (BGF MDI) in Romania in real-life setting, up to 6 month of…
- Trial name
- COnCORD (NCT06368427)
- Testing
- budesonide / glycopyrronium / formoterol
- Where
- 16 sites in Romania
- Volunteers
- 10 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Safety and Efficacy of Multiple Doses of Canakinumab (ACZ885) in Chronic Obstructive Pulmonary Disease (COPD) Patients
Was to evaluate the safety, tolerability and efficacy of multiple doses of canakinumab (ACZ885) vs. placebo when administered via intravenous infusion (IV), on pulmonary function in patients with COPD
- Trial name
- NCT00581945
- Testing
- Canakinumab
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novartis
Pulmonary Disease, Chronic Obstructive
To Evaluate Real-World Effectiveness of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol (FF/UMEC/VI) in a Single Inhaler (Trelegy Ellipta) in Participants With Symptomatic COPD
The primary objective of this study is to evaluate the effectiveness of TRELEGY ELLIPTA on health status in participants with symptomatic COPD.
- Trial name
- NCT05535972
- Testing
- FF/UMEC/VI
- Where
- China
- Volunteers
- 463 people
- Sponsor
- GlaxoSmithKline
COPD
COPD Exacerbations
Detecting exacerbations to prevent a severe and / or to early treat an exacerbation is crucial in patients with COPD in order to prevent hospitalization.
- Trial name
- NCT02798575
- Testing
- Astral 150 ventilator
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Diabetes Mellitus, Chronic Obstructive Pulmonary Disease
A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With COPD
A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT00138671
- Testing
- Subcutaneous Insulin, Inhaled Insulin
- Where
- 88 sites in United States, Brazil and 3 more
- Volunteers
- 105 people
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease, Asthma
Hyperoxia During Pulmonary Rehabilitation in Chronic Lung Disease - Does it Matter?
Chronic respiratory diseases are a global burden. Treatment options have improved in recent years, pulmonary rehabilitation plays a key role.
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- NCT06174207
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Chronic Obstructive Pulmonary Disease
Evidence-based Analysis of Low-dose CT in Management of COPD
Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of chronic morbidity and mortality worldwide.
- Trial name
- NCT02599883
- Testing
- Low-Dose Computed Tomography
- Volunteers
- 195 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Chronic Obstructive Pulmonary Disease
RECEIVER: Digital Service Model for Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a serious but treatable chronic health condition. Optimised management improves symptoms, complications, quality of life and survival.
- Trial name
- NCT04240353
- Testing
- COPD digital support service
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- NHS Greater Glasgow and Clyde
Chronic Obstructive Pulmonary Disease
A Study to Evaluate Biomarkers in Chronic Obstructive Pulmonary Disease
The primary objective of this study is to identify biomarkers that can be used for evaluation of efficacy in subjects presenting with AECOPD
- Trial name
- NCT01268072
- Where
- 10 sites in United States, Canada
- Volunteers
- 61 people
- Sponsor
- MedImmune LLC
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