Clinical trials: Chronic Obstructive Pulmonary
COPD
Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Molecular mechanisms of COPD exacerbations and the modulating effect of low dose theophylline on that inflammation are elucidated in this project.
- Trial name
- NCT00671151
- Testing
- Theophylline
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Son Dureta
COPD (Chronic Obstructive Pulmonary Disease), Nursing Care
Investigation of the Attitudes of Patients With Chronic Obstructive Pulmonary Disease Towards Traditional Complementary Medicine Practices
Individuals with Chronic Obstructive Pulmonary Disease need the help and support of caregivers in issues such as limitations in their physical and social functions, inadequacy, social isolation, dependency, and continuing their…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Nursing Care, Holistic Care
- Trial name
- NCT07031401
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
COPD, ILD
Recognition of Early Pulmonary Structural Changes by Using Real-time High Fidelity Expiratory CO2 Analysis
In this study the investigators aim to detect and characterize structural airway and lung vessel changes due to COPD or ILD as assessed by real-time high fidelity expiratory CO2 analysis.
- Trial name
- NCT05092035
- Testing
- single high-fidelity expiratory CO2 analysis
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Chronic Low-back Pain, Depression
Pain Neuroscience Education for Depression
This study will look at the effects of Pain Neuroscience Education on a Depression outcome tool in patients with chronic low back pain.
- Trial name
- PNEdepress (NCT04023435)
- Testing
- PNE edcuation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Ambrose University
Lung Cancer, Nonsmall Cell, COPD
Breathe Easier II: A Dyad-based Multiple Behavior Intervention
This pilot randomized control trial (RCT) will test a 12-week, multiple behavior intervention physical activity and stress management for survivors with early stage lung cancer (stages I-III) and their family members (1 survivor…
- Conditions
- Lung Cancer, Nonsmall Cell, COPD, Self-Management, Physical Inactivity
- Trial name
- BE (NCT05956782)
- Testing
- Breathe Easier
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
COPD, Nurse-Patient Relations
Effectiveness of Motivational Interviewing in Patients With COPD
To determine the effect of motivational interviewing based on Pender's health promotion model on patient-reported outcomes in patients with COPD.
- Trial name
- NCT06783582
- Testing
- Motivational interviewing based on Pender's health promotion model
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zeynep Yildirim
COPD, Lung Function
Lung Function Decline and Disease Risk From Young Adulthood to Middle Age
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, but markers that predict risk of developing disease outside of cigarette smoking have not been identified.
- Conditions
- COPD, Lung Function, Heart - Lung Interaction, Restrictive Lung Disease
- Trial name
- CARDIA Lung (NCT02245178)
- Testing
- Lung spirometry, CT scan analysis
- Volunteers
- 3,193 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cardiopulmonary Disease
SGA for TEE: Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease.
Increasingly, transesophageal echos (TEEs) are being done on high risk patients. A TEE is a short procedure done with deep sedation, but poses an increased risk of apnea/ hypoxemia in those with pulmonary disease.
- Trial name
- SGA-TEE (NCT04939220)
- Testing
- TEE with SGA, TEE with Deep Sedation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Obstructive Pulmonary Disease
Effects of Chest Physiotherapy and Lungs Squeezing Technique in Patients With Chronic Obstructive Pulmonary Disease.
Chronic pulmonary obstructive disease refers to a group of lungs problems that includes blockage of airway and difficulty in breathing. It includes mostly emphysema, asthma and chronic bronchitis.
- Trial name
- NCT06480435
- Testing
- Chest physical Therapy, Lungs squeezing technique
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riphah International University
COPD, Asthma
Cardiorespiratory Diagnostic Study
This study uses a new breathing device called 'N-Tidal C' handset which measures breathing patterns. Investigators have found that people with cardiac and respiratory illnesses breathe out a gas, called carbon dioxide (CO2), in a…
- Conditions
- COPD, Asthma, Lung Cancer, Anemia
- Trial name
- CARES (NCT04939558)
- Testing
- N-Tidal C handset
- Where
- United Kingdom
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- TidalSense
Pulmonary Disease, Chronic Obstructive
Absorption & Elimination of Radiolabelled GSK2269557
GSK2269557 is being developed as an anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD) and other inflammatory lung diseases such as asthma.
- Trial name
- NCT03315559
- Testing
- [14C]-GSK2269557 IV infusion, GSK2269557 via DPI, [14C]-GSK2269557 oral solution
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant
The study will assess the Pharmacokinetic (PK) and safety of BGF MDI [Budesonide/glycopyrronium/formoterol (BGF) metered dose inhaler (MDI)] formulated with 2 different propellants :Hydrofluoroolefin (HFO) and Hydrofluoroalkane…
- Trial name
- NCT05477108
- Testing
- Treatment A (BGF MDI HFO with oral activated charcoal), Treatment B (BGF MDI HFA with oral activated charcoal)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Influence of Electronic Cigarettes in the Evaluation of the Inflammatory Response in Patients With a Diagnosis of COPD
This study evaluates the local and systemic inflammatory response in the airway in COPD patients who consume electronic cigarettes compared with conventional cigarette smokers.
- Trial name
- NCT02892396
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fundacio Catalana de Pneumologia
Chronic Obstructive Pulmonary Disease
Raman Analysis of Saliva as Biomarker of COPD
Chronic Obstructive Pulmonary Disease (COPD) is a debilitating and chronic lung syndrome that causes accelerated lung function decline and death in the 20% of cases.
- Trial name
- CORSAI (NCT04628962)
- Testing
- Collection and Raman analysis of saliva for the database
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Chronic Obstructive Pulmonary Disease
Prevalence of Undiagnosed Chronic Obstructive Pulmonary Disease Sufferers in the Region of Murcia
The purpose of this study is determine the prevalence of undiagnosed Chronic Obstructive Pulmonary Disease (COPD) in population served and with exposure to cigarettes in the Region of Murcia
- Trial name
- NCT01380470
- Where
- Spain
- Volunteers
- 1,052 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Assess Drug Absorption of Fixed Dose Combinations of Budesonide, Glycopyrronium, and Formoterol
The study will evaluate bioavailability, pharmacokinetics, safety, and tolerability of budesonide, glycopyrronium and formoterol (BGF) metered dose inhaler (MDI) formulated with 3 different propellants: Propellant 1 (Treatment A…
- Trial name
- NCT04600505
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma, Allergy
The Leaky Lung Test
This is a clinical trial designed to test the hypothesis that measuring the absorption and excretion of inhaled mannitol will provide a clinically useful marker of airway epithelial permeability in asthma.
- Conditions
- Asthma, Allergy, Reactive Airway Disease, Lung Diseases, Obstructive
- Trial name
- NCT02306473
- Testing
- Mannitol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Chronic Obstructive Pulmonary Disease, Emphysema
Macrophages in Smokers' Lung
Cigarette smoking causes an increase in inflammation in the lungs. In about 20% of smokers this inflammation leads to damage in lungs including making holes in the lung tissue.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00298402
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Asthma, Chronic Obstructive Pulmonary Disease (COPD), or Chronic Lung Disease (E.G., Chronic Bronchitis and Restrictive Lung Diseases Such as Asbestosis), The Effect of Yoga, Paranayama Yoga Practice on Respiratory Diseases
EFFECT OF PRANAYAMA YOGA ON COPD
The aim of the study In this study, pranayama yoga practices are the sub-dimensions of respiratory parameters, symptom and disease affection level, psychosocial adjustment and psychosocial adjustment in individuals with COPD.
- Trial name
- COPD (NCT06022627)
- Testing
- Pranayama Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
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