Clinical trials: Chronic Obstructive Pulmonary
Chronic Obstructive Pulmonary Disease
Safety, Preliminary Pharmacokinetics and Bronchodilator Properties of V0162
Pulmonary administered anticholinergic agents have shown their importance in the chronic obstructive pulmonary disease (COPD) management to reduce morbidity, disability and mortality.
- Trial name
- NCT01348555
- Testing
- Bronchodilatator
- Where
- 2 sites in Belgium, France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Asthma, COPD
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT04624490
- Testing
- Hyperpolarized Xe129
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mario Castro, MD, MPH
Pulmonary Disease, Chronic Obstructive, Interstitial Pulmonary Fibrosis
An Atlas of Airways at a Single Cell Level in Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Controls
The increasing incidence of chronic respiratory disease is a public health problem that affects hundreds of thousands of people worldwide at all ages.
- Trial name
- DISCOVAIR (NCT04529993)
- Testing
- Bronchoscopy
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pulmonary Disease, Chronic Obstructive
Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD
The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and…
- Trial name
- NCT01909544
- Testing
- Fatiguing exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Pulmonary Disease, Chronic Obstructive
A Phase I Pharmacokinetic Study of Fluticasone Furoate /Umeclidinium Bromide/Vilanterol (100/62.5/25 Microgram [mcg]) After Single and Repeat Dose Administration From a Dry Powder Inhaler in Healthy Chinese Subjects
This is an open-label study to evaluate the PK of FF/UMEC/VI in dose combinations of 100/62.5/25 mcg after single and repeat dose administration from a DPI in healthy Chinese subjects.
- Trial name
- NCT02837380
- Testing
- FF, VI/UMEC
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cholecystitis, Chronic
Outcomes of Three Ports Versus Four Ports Laparoscopic Cholecystectomy, Sohag General Surgery Department Experience
To compare the outcomes of three ports and four ports Laparoscopic Cholecystectomy
- Trial name
- NCT06264115
- Testing
- Laparoscopic Cholecystectomy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pulmonary Disease, Chronic Obstructive
A Study to Look at How GSK1325756 is Taken up by the Body When Given by Mouth When Stomach Acid is Reduced
This is a Phase I study to assess the combined effects of food and suppression of gastric acid secretion on the relative bioavailability of an immediate release (IR) tablet formulation and prototype bioenhanced formulations of…
- Trial name
- NCT01453478
- Testing
- GSK1325756
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
To Evaluate Effects of GSK2256294 on Pulmonary Artery Pressure in Healthy Volunteers Under Normoxic and Hypoxic Conditions
The study evaluates the effect of GSK2256294 exposure at steady state on pulmonary artery systolic pressure (PASP) in healthy volunteers, under hypoxic conditions, after 7 days of dosing.
- Trial name
- NCT02262689
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Obstructive Pulmonary Disease
Systemic Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
COPD is ranked number 3 by the WHO list of important diseases worldwide and is the only disease with increasing mortality. The pathogenesis of cigarette smoke-induced COPD is obscure, therefore more insight is needed to design…
- Trial name
- NCT00850863
- Where
- Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Top Institute Pharma
Pulmonary Disease, Chronic Obstructive
Blood Levels and Effects of GSK1325756 in Healthy Adult Volunteers Aged 40 to 80 Years Old
This study will invite two groups of volunteers to participate. The data from one group of volunteers will be used to find out how much study drug, known as GSK1325756, is in the blood after taking the drug twice in one day.
- Trial name
- NCT01267006
- Testing
- GSK1325756
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Validating the Use of Frailty Measurements to Predict Care & Quality of Life
The aim of this research program is to validate frailty measurements as a risk stratification tool to predict deteriorations in patient-reported outcomes, to gain a better understanding of patient preferences for care within…
- Trial name
- NCT06325241
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Healthy
DBM-1152A Inhalation Solution in Healthy Volunteers
This is a single-center, randomized, double-blind, placebo-controlled Phase 1b study to evaluate the safety, tolerability, and pharmacokinetics (PK) of multiple-dose DBM-1152A inhalation solution in healthy Chinese adults.
- Trial name
- NCT07439419
- Testing
- DBM-1152A
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
Chronic Obstructive Pulmonary Disease
Airway Clearance Study
The purpose of the study is to evaluate how the airways in COPD patients, compared to healthy volunteers, absorb steroid drugs from Symbicort Turbuhaler and Seretide Diskus.
- Trial name
- NCT00379028
- Testing
- Budesonide/Formoterol Turbuhaler, Salmeterol/Fluticasone Diskus
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COPD
Imaging Activated Macrophages in the Lungs
To test whether folate-based positron emission tomography (PET) imaging using 68Ga-EC2115 can differentiate chronic obstructive pulmonary disease (COPD) patients from control subjects and determine whether the PET signal…
- Trial name
- NCT03494114
- Testing
- Ga-EC2115
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive
Smart Textile Sensor System for Health Monitoring
The present study will investigate a set of biomedical sensors with a wireless data communication system and evaluate the sensors' recording quality.
- Conditions
- Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive, Blood Pressure, Heart Rhythm Disorder
- Trial name
- NCT05473702
- Testing
- Nanowear SimpleSense Wearable monitoring device
- Where
- 3 sites in United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Nanowear Inc.
Copd, Smoking
Clinical Features of Smoker Patients With Chronic Obstructive Pulmonary Disease
Smoking is the most important factor in the etiology of COPD. Some of the patients with COPD continue to smoke despite knowing this situation or they cannot quit even if they want.
- Trial name
- NCT04711629
- Testing
- Clinical Tests
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Asthma, Pulmonary Disease, Chronic Obstructive
Right Heart Dysfunction and Pulmonary Hypertension Evaluation in Airway Disease Using Cardiac Magnetic Resonance
Poor function of the right side of the heart and rise in pressure of the blood vessels leading to the lungs are two main heart-related factors that are associated with worsening of airway disease.
- Trial name
- RiPAIR (NCT02865577)
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Leicester
COPD
Determinants of Onset and Progression of COPD in Young Adults
COPD (Chronic Obstructive Pulmonary Disease) is a Public Health problem due to its impact in the patient's quality of life, high prevalence, growing incidence and socioeconomic implication.
- Trial name
- EARLY COPD (NCT02352220)
- Where
- Spain
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Borja Cosio
Chronic Obstructive Pulmonary Disease
Exhaled Breathing Condensate (EBC) Features and Lung Function Decline in Chinese Adults
Chronic obstructive lung disease (COPD) is a worldwide leading and still increasing cause of chronic morbidity and mortality. The important issue of COPD is its delayed diagnosis.
- Trial name
- NCT02037828
- Where
- China
- Volunteers
- 2,440 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
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