Clinical trials: Chronic Obstructive Pulmonary
COPD
Crossover Study to Assess the Efficacy of PT003 With and Without a Valved Holding Chamber in Subjects With Moderate to Severe COPD
This is a Randomized, Phase III, Two-period, Open-label, Chronic-dosing (7 Days), Multi-center, Crossover Study to Assess the Efficacy of PT003 in Subjects with Moderate to Severe COPD with and without a Valved Holding Chamber.
- Trial name
- NCT02454959
- Testing
- GFF MDI (PT003) with Aerochamber, GFF MDI (PT003) without Aerochamber
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- Pearl Therapeutics, Inc.
COPD Exacerbation Acute, Nutrition Poor
Is a Collective Person-centered Dialogue Intervention for Hospitalised COPD Patients Feasible?
The aim of this mixed methods trial is to investigate the feasibility of a collective person-centred dialogue (COPE-D) intervention delivered by an interdisciplinary team for a population of patients hospitalised and diagnosed…
- Conditions
- COPD Exacerbation Acute, Nutrition Poor, Physical Inactivity, Relatives
- Trial name
- COPE-D (NCT06242301)
- Testing
- The collective person-centered dialogue intervention
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Hvidovre University Hospital
Pulmonary Emphysema
Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone Marrow, Cultured Under the Hypoxia in the Treatment of Patients With Severe Pulmonary Emphysema
Actively developing stem cells (SCs) transplantation techniques cause natural interest to the problem of regeneration in the lungs.
- Trial name
- NCT01849159
- Testing
- Mesenchymal stem cells, Reference therapy: 400 mL of 0.9% NaCl solution
- Where
- Russia
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Chronic Obstructive Pulmonary Disease (COPD)
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
The purpose of this study is to investigate the safety and tolerability of Metformin and how it changes blood markers associated with aging in persons who have chronic obstructive pulmonary disease (COPD) who do not have diabetes.
- Trial name
- INSPIRE-COPD-E (NCT07275359)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Chronic Graft-Versus-Host Disease
A Study of Panobinostat (LBH589) as Second-Line Therapy in Patients With Chronic Graft-Versus-Host Disease
There is a clear need for effective, steroid-sparing agents for the management of chronic graft-versus-host disease (GVHD). Thus, agents like Histone deacetylase (HDAC) inhibitors, with the potential of decreasing…
- Trial name
- NCT01028313
- Testing
- LBH589, Methylprednisolone
- Where
- United States
- Sponsor
- SCRI Development Innovations, LLC
Pulmonary Disease, Chronic Obstructive
Study to Assess the Safety of Ipratropium Bromide, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Study to assess the safety of two-week administration of 80 and 160 mcg of ipratropium bromide as delivered by the RESPIMAT® device and as determined by 24 hours ambulatory ECG monitoring in COPD patients.
- Trial name
- NCT02236182
- Testing
- Ipratropium Bromide low dose, Ipratropium Bromide high dose
- Volunteers
- 57 people
- Sponsor
- Boehringer Ingelheim
Lymphocytic Bronchi(Oli)Tis Post-lung Transplantation
Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation
This study investigates the role of azithromycin treatment for lymphocytic bronchitis/bronchiolitis after lung transplantation.
- Trial name
- AZI002 (NCT01109160)
- Testing
- Azithromycin Dihydrate
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- KU Leuven
Pulmonary Disease, Chronic Obstructive
A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The study evaluates the efficacy of fluticasone furoate/umeclidinium bromide/vilanterol (FF/UMEC/VI) to reduce the annual rate of moderate and severe exacerbations compared with dual therapy of FF/VI or UMEC/VI in subjects with…
- Trial name
- NCT02164513
- Testing
- fluticasone furoate (FF), vilanterol (VI), umeclidinium bromide (UMEC)
- Where
- 998 sites in United States, Argentina and 35 more
- Volunteers
- 10,355 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive, Microbiota
Analysis of the Microbiome in the Healthy Smokers and COPD Patients
This study is to build a microbiome cohort by collecting sputum and fecal samples every few months for three years from healthy smokers and chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT04336423
- Testing
- Obtain samples from sputum and feces
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease, Balance
Investigation of Impairments in Body Functions and Structures, Activities and Participation Restrictions in COPD
This cross-sectional study aims to investigate to the impairments in body functions and structures, activities and participation restrictions according to the International Classification of Functioning, Disability and Health…
- Conditions
- Chronic Obstructive Pulmonary Disease, Balance, Activity, Motor, Participation, Patient
- Trial name
- NCT05632120
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Obstructive Pulmonary Disease
DETECT-Register DocumEnTation and Evaluation of a COPD Combination Therapy
Prospective, multi-centre, non-interventional study to collect findings about the effects of LABA/LAMA (Long Acting Beta2-Agonists / Long Acting Muscarinic Antagonists) combination preparations on COPD (Chronic obstructive…
- Trial name
- DETECT (NCT02552160)
- Where
- 180 sites in Germany
- Volunteers
- 3,732 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Breathlessness
Fan Therapy in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a common smoking related lung disease. The main symptom in breathlessness. Pulmonary Rehabilitation (PR) - a supervised group exercise and education class - is an effective…
- Trial name
- NCT03137524
- Testing
- Hand Held Fan Therapy
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- City, University of London
Pulmonary Disease, Chronic Obstructive
A Study in the US Based on Pharmacy and Medical Claims That Compares How Well Stiolto® and Trelegy® Work in People With Chronic Obstructive Pulmonary Disease (COPD)
This study looks at data from people with chronic obstructive pulmonary disease (COPD). Some used Stiolto Respimat and the others Trelegy Ellipta as their first treatment for COPD.
- Trial name
- NCT05169424
- Testing
- Trelegy Ellipta, Stiolto Respimat, Tiotropium + Olodaterol (5/5 mcg)
- Where
- United States
- Volunteers
- 9,117 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
Airway Macrophages and Sputum Milieu in Adult Subjects With Airflow Obstruction
Airway macrophage impairment is a central feature in the immunopathogenesis of chronic obstructive pulmonary disease, regardless of smoking status.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic, Occupational Diseases, Tobacco Use Disorder
- Trial name
- NCT00871637
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Obstructive Pulmonary Disease (COPD)
Aclidinium/Formoterol Fixed Combination Dose Finding Study
The study seeks to determine the optimal dose of the Aclidinium/Formoterol combination for investigation in Phase III clinical trials
- Trial name
- NCT00626522
- Testing
- Aclidinium bromide and formoterol
- Where
- 9 sites in Australia, Czechia and 2 more
- Volunteers
- 808 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
BDP/FF Versus Formoterol Fumarate (FF) in Patients With Severe COPD (Lung Function and Exacerbation Rate)
a 48-week, 2-arm parallel group, "fixed combination" beclomethasone dipropionate plus formoterol fumarate versus formoterol in patients with severe chronic obstructive pulmonary disease
- Trial name
- NCT00929851
- Testing
- CHF1535, Formoterol fumarate
- Where
- United Kingdom
- Volunteers
- 1,199 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD, COPD Exacerbation
Nebulizer Versus Dry Powdered Inhalers for Chronic Obstructive Pulmonary Disease (COPD)
This will be a non-blinded feasibility (pilot) study comparing triple therapy nebulizer vs dry powdered inhalers (DPI) for care transitions in Chronic obstructive pulmonary disease (COPD) exacerbation patients.
- Trial name
- NCT03219866
- Testing
- Nebulizers, Dry Powder Inhaler, Brovana
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain
NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
The investigators investigated whether a strictly controlled pain management with patients participating in a clinical study can attenuate persistence of post-thoracotomy pain.
- Trial name
- NCT01541137
- Testing
- Diclofenac, parecoxib/ valdecoxib, patient controlled epidural analgesia
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Chronic Obstructive Pulmonary Disease
Clinical Impact of Pharmaceutical Consultations in Patients Treated for Chronic Obstructive Pulmonary Disease at Home
The implementation of pharmaceutical consultations in the city or at the hospital could modify the occurrence of exacerbations related to chronic obstructive pulmonary disease after return of the patient to his home.
- Trial name
- BPCObs (NCT03704545)
- Testing
- Pharmaceutical consultation at the hospital, Pharmaceutical consultation at the pharmacy, Follow-up pharmaceutical consultation at the pharmacy
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Obstructive Pulmonary Disease (COPD)
Tolerability/Safety and Efficacy of Inhaled AZD4818 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to see if treatment with AZD4818 for four weeks is tolerable, safe and effective in treating COPD and, if so, how it compares with placebo.
- Trial name
- TOP (NCT00629239)
- Testing
- AZD4818
- Where
- 12 sites in Denmark, Finland and 3 more
- Volunteers
- 65 people
- Sponsor
- AstraZeneca
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