Clinical trials: Chronic Obstructive Pulmonary Disease, completed
Chronic Bronchitis
Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis
A study to assess the safety and efficacy of moxifloxacin compared to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbation of chronic bronchitis.
- Trial name
- NCT00656747
- Testing
- Avelox (Moxifloxacin, BAY12-8039), Amoxicillin clavulanic acid
- Where
- 220 sites in Andorra, Argentina and 29 more
- Volunteers
- 1,372 people
- Sponsor
- Bayer
Chronic Obstructive Pulmonary Disease
Signaling Pathway Activation After Exercise in Patients With Chronic Obstructive Pulmonary Disease
Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary disease (COPD). Although resistance exercises increase strength and muscle mass in patients with COPD, the response to training appears to be…
- Trial name
- SIM (NCT01561625)
- Testing
- exercise
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease
An Evaluation of Post Discharge Utilization Among Patients With an Acute Exacerbation of COPD
Patients who are hospitalized at select Carolinas Healthcare System (CHS) sites with Chronic Obstructive Pulmonary Disorder (COPD) acute exacerbation symptoms will be treated per the CHS COPD Clinical Pathway.
- Trial name
- NCT03207776
- Testing
- Usual Care, COPD Clinical Pathway
- Where
- 8 sites in United States
- Volunteers
- 4,832 people
- Sponsor
- Wake Forest University Health Sciences
Pulmonary Disease, Chronic Obstructive
Efficacy and Safety of Tiotropium Compared to Salmeterol and Placebo in Patients With Chronic Obstructive Bronchitis (COPD)
The objective of this study is to compare the long-term (six month) bronchodilator efficacy and safety of tiotropium inhalation capsules, salmeterol inhalation aerosol and placebo inpatients with COPD.
- Trial name
- NCT02173691
- Testing
- Tiotropium inhalation powder capsules, Salmeterol inhalation aerosol
- Volunteers
- 584 people
- Sponsor
- Boehringer Ingelheim
COPD
Inspiratory Muscle Training on Respiratory Muscle Function，Quality of Life and Exercise Capacity in Stable COPD
Comparable RCTs of clinical therapeutic effects using respiratory physiology-oriented IMT device in different operation principle in COPD are so far lacking.
- Trial name
- NCT03101774
- Testing
- Threshold inspiratory muscle training, Resistive inspiratory muscle training, Control group
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Cough Variant Asthma
Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
- Trial name
- NCT03573284
- Testing
- fractional exhaled nitric oxide(FeNO), impulse oscillometry(IOS)
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Zhujiang Hospital
Copd
Oral Supplementation During PR Participation in COPD
Chronic obstructive pulmonary disease (COPD) is a very common and chronic lung condition and is a leading cause of morbidity and death.
- Trial name
- NCT06324214
- Testing
- Urolithin A (Mitopure)
- Where
- 3 sites in Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Asthma, COPD
A Clinical Study in Healthy Subjects to Evaluate 9MW1911 Injection
This is a Phase 1, randomized, placebo-controlled study, enrolling approximately 38 healthy adult subjects (18-65 yrs). The purpose of this study is to evaluate the safety, tolerability and PK of single ascending dose of 9MW1911…
- Conditions
- Asthma, COPD, Atopic Dermatitis
- Trial name
- NCT05170243
- Testing
- 9MW1911 Injection
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Respiratory Disease, Lung Cancer
Evaluate Efficacy of Respiratory Rehabilitation Personalized Mobile Services for Respiratory Diseases
This trial is multicenter prospective study to evaluate clinical efficacy of respiratory rehabilitation personalized mobile services for respiratory disease.
- Conditions
- Respiratory Disease, Lung Cancer, COPD
- Trial name
- NCT03432117
- Testing
- Fixed respiratory rehabilitation, Responsive respiratory rehabilitation
- Where
- 5 sites in South Korea
- Volunteers
- 179 people
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease Transcription Factor and Cytokine Study
Chronic Obstructive Pulmonary Disease Transcription Factor and Cytokine Study.
- Trial name
- NCT02557958
- Testing
- Azithromycin
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Pulmonary Disease, Chronic Obstructive, Breathing Exercises
Effects of an Exercise Rehabilitation Programme With a Nasal Inspiratory Restriction Device in COPD Patients
This study evaluates the effects of a nasal restriction device for inspiratory muscle training (FeelBreathe) after 8 weeks of exercise intervention on exercise capacity, quality of life, dyspnea and inspitarotory muscle strength…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Breathing Exercises, Exercise Tolerance
- Trial name
- EPOC_2_0 (NCT03936348)
- Testing
- Exercise training program with and without FB
- Volunteers
- 16 people
- Sponsor
- University of Cadiz
Pulmonary Disease, Chronic Obstructive
To Evaluate Effects of GSK2256294 on Pulmonary Artery Pressure in Healthy Volunteers Under Normoxic and Hypoxic Conditions
The study evaluates the effect of GSK2256294 exposure at steady state on pulmonary artery systolic pressure (PASP) in healthy volunteers, under hypoxic conditions, after 7 days of dosing.
- Trial name
- NCT02262689
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Disturbed Blood Flow Induces Endothelial Dysfunction in Severe Chronic Obstructive Pulmonary Disease
The aim of the study is to determine if increased retrograde shear would further deteriorate the already impaired vascular function in severe COPD patients.
- Trial name
- NCT03004352
- Testing
- retrograde flow, oxygen
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Chronic Obstructive Pulmonary Disease
Efficacy of DNK333 in Patients With COPD and Cough
This study evaluates the efficacy and safety of two weeks treatment of DNK333 in patients with COPD and cough.
- Trial name
- NCT01287325
- Testing
- DNK333 100 mg twice daily
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Novartis
Chronic Obstructive Pulmonary Disease
Safety and Efficacy of Multiple Doses of QAX028 in Chronic Obstructive Pulmonary Disease (COPD) Patients
This study will assess the bronchodilator effects of multiple doses of QAX028 at two different dose levels when compared to tiotropium and placebo in a COPD population.
- Trial name
- NCT01068613
- Testing
- QAX028, Tiotropium
- Where
- 4 sites in United States
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Efficacy, Tolerability and Safety of NVA237 in Patients With Chronic Obstructive Pulmonary Disease
This study will assess the efficacy, tolerability and safety of NVA237 compared to tiotropium when added on to fluticasone/salmeterol in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT01513460
- Testing
- NVA237 50µg once daily, Tiotropium 18µg once daily, Flu/Sal
- Where
- 71 sites in Australia, New Zealand
- Volunteers
- 773 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Chronic Bronchiolitis or Resistant Asthma?
Chronic Bronchiolitis or Resistant Asthma? Testing a way to diagnosis and treatment
- Trial name
- NCT00368342
- Testing
- Erythromycin, Azithromycin , Clarithromycin
- Sponsor
- Baqiyatallah Medical Sciences University
Obstructive Chronic Pulmonary Disease, Emphysema
Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients
Aims: To prove the benefits of an specific strength training program in COPD patients compared to those achieved with the traditional endurance training.
- Trial name
- NCT01336283
- Testing
- Endurance training, Strength training, Combined training
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Chronic Obstructive Pulmonary Disease
Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)
Primary Objective: Evaluate the efficacy of itepekimab compared with placebo on the annualized rate of acute moderate-or-severe COPD exacerbations in former smokers with moderate-to-severe COPD Secondary Objectives: Evaluate the…
- Trial name
- AERIFY-1 (NCT04701983)
- Testing
- Itepekimab SAR440340
- Where
- 232 sites in United States, Argentina and 19 more
- Volunteers
- 1,127 people
- Sponsor
- Sanofi
Chronic Obstructive Pulmonary Disease
Evidence-based Analysis of Low-dose CT in Management of COPD
Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of chronic morbidity and mortality worldwide.
- Trial name
- NCT02599883
- Testing
- Low-Dose Computed Tomography
- Volunteers
- 195 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
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