Clinical trials: Chronic Obstructive Pulmonary Disease (COPD)
COPD
Association Between Handgrip Strength and Small Airway Disease in Patients with Stable Chronic Obstructive Pulmonary Disease
The goal of this observational study is to investigate the correlation between handgrip strength and small airway disease among patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT06223139
- Testing
- Handgrip strength
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Thammasat University
COPD, Chronic Obstructive Pulmonary Disease
Home-based Pulmonary Rehabilitation for COPD Patients
Objectives The objective of this project is to motivate patients with COPD to incorporate the habit of doing daily mindful physical activity by using the proposed home-based pulmonary rehabilitation program that integrates video…
- Trial name
- NCT04820257
- Testing
- Home based exercise
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
COPD
Evaluation of Airway Gene Expression in COPD and Controlled Populations
To explore potential proteins that may be used to develop novel therapies for COPD. This will be accomplished by acquiring material from the lower respiratory tract via endobronchial brushings.
- Trial name
- NCT00571792
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Obstructive Pulmonary Disease (COPD), Blood Flow Restriction Training (BFRT)
Effects Of Low-Load Blood Flow Restriction Training Of The Upper Extremity In Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation, progressive dyspnea, and peripheral muscle dysfunction, significantly impairing functional capacity and quality of life.
- Trial name
- NCT07469111
- Testing
- Low-Load Blood Flow Restriction Training (LL-BFRT) + Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Inonu University
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Pulmonary Rehabilitation on Respiratory Sounds in Patients With COPD
The effect of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) has been based on systemic outcome measures, however, little is known about the effectiveness of this intervention on patients'…
- Trial name
- NCT02050711
- Testing
- Pulmonary rehabilitation, Usual care
- Where
- Portugal
- Volunteers
- 106 people
- Sponsor
- Aveiro University
COPD
Triple Therapy in Real-life: Impact on Adherence and Health Status (TRITRIAL)
The mean objectives are to evaluate the impact of BDP/FF/G fixed combination on health-status and adherence
- Trial name
- NCT03963167
- Testing
- BDP/FF/G fixed combination
- Where
- Italy
- Volunteers
- 661 people
- Sponsor
- Chiesi Italia
Ultrasonography, Mechanical Ventilation Weaning
The Use of Diaphragmatic Ultrasonography in Mechanical Ventilation Weaning Decision in COPD Patient
The aim of this study is to evaluate the use of diaphragmatic ultrasonography in taking mechanical ventilation weaning decision and predicting outcome in Chronic obstructive pulmonary disease patient.
- Conditions
- Ultrasonography, Mechanical Ventilation Weaning, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07082361
- Testing
- conventional clinical criteria of weaning from mechanical ventilation, conventional clinical criteria and ultrasonic criteria for weaning
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Tanta University
Chronic Obstructive Pulmonary Disease
Influence of Reliance on Historical Blood Eosinophil Counts on ICS Prescribing by GOLD 2019 Thresholds in COPD
Blood eosinophils are a type of white blood cell that helps fight infection. They have a number of different functions but are primarily involved in numerous inflammatory processes.
- Trial name
- BECCOPD (NCT04571983)
- Testing
- Blood Eosinophil counts - comparing historical with stable state
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Asthma, COPD
Non-inferiority of Portable Versus Desktop Spirometry
The investigators compared the ventilation parameters for volume and flow obtained from standard spirometry procedures from patients presently monitored and treated for asthma or chronic obstructive pulmonary disease (COPD) using…
- Trial name
- NCT03894475
- Testing
- AioCare, Spirometer USB CPFS/D (MGC Diagnostics)
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Pulmonary Disease, Chronic Obstructive
A Comparative Study Between Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy Versus Tiotropium Monotherapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
COPD is a progressive disease characterized by increasing obstruction to airflow and the progressive development of respiratory symptoms including chronic cough, increased sputum production, dyspnea and wheezing.
- Trial name
- NCT03474081
- Testing
- FF/UMEC/VI, Tiotropium, Albuterol/salbutamol
- Where
- 72 sites in United States, Poland and 1 more
- Volunteers
- 800 people
- Sponsor
- GlaxoSmithKline
Allergic Bronchiolitis
Investigation of the Frequency of Hereditary Hyper Alpha-tryptasemia in Patients With Elevated Basal Tryptasemia
The aim of the study is to assess the number of patients with elevated blood tryptase for whom this elevation could be linked to a hereditary alpha-tryptase secretion abnormality or hyper-alpha-tryptasemia.
- Trial name
- HaT (NCT06133907)
- Testing
- Serum
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
COPD
Effectiveness of Harmonica Playing in Improving Lung Function Among COPD Patients
Although it has been documented that harmonica playing plays a role in the pulmonary rehabilitation (PR) of patients with chronic obstructive pulmonary disease (COPD), current studies are limited by small sample sizes…
- Trial name
- NCT05995847
- Testing
- Harmonica playing program plus basic PR care with routine follow-up, Basic PR care with routine follow-up
- Where
- 2 sites in China
- Volunteers
- 248 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pulmonary Disease, Chronic Obstructive
QTc Study GSK573719+GW642444
This is a randomized, placebo controlled, four period incomplete block,crossover thorough QT study to estimate the effect of repeat dose GSK573719/GW642444M (Vilanterol) combination and GSK573719 monotherapy on the QTc interval…
- Trial name
- NCT01521377
- Testing
- Moxifloxacin, GSK573719/Vilanterol 125/25mcg, GSK573719
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Diseases, COPD
Effect of IMT in Patients After Acute Exacerbations of COPD
The goal of this clinical trial is to test whether home-based inspiratory muscle training can reduce hospital readmissions and death in patients recovering from a severe acute exacerbation of chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Diseases, COPD, Symptom Exacerbation
- Trial name
- IN-SPIRED (NCT07213128)
- Testing
- Training
- Where
- 12 sites in Belgium
- Volunteers
- 358 people
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease
The Influence of an Acute Exacerbation During Pulmonary Rehabilitation in COPD Patients Awaiting Lung Transplantation
Data from chronic obstructive pulmonary disease patients awaiting lung transplantation which performed a pulmonary rehabilitation program will be analyzed retrospectively.
- Trial name
- NCT04363723
- Testing
- Pulmonary Rehabilitation
- Where
- Germany
- Volunteers
- 559 people
- Sponsor
- Klaus Kenn
Chronic Hypersecretions
Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion
Mechanical devices to increase the individual's bronchial hygiene are commonly used in patients with chronic retention of secretions and abnormal cough reflex.
- Trial name
- UNIKO (NCT00700388)
- Testing
- TPEP device (UNIKO), MABT (Manually assisted breathing techniques)
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Villa Pineta Hospital
Pulmonary Disease, COPD
Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate a multifaceted intervention to improve the quality of end-of-life communication between patients with COPD and their primary care providers using information about patients preferences for…
- Conditions
- Pulmonary Disease, COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00106080
- Testing
- Audit and Feedback
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- VA Office of Research and Development
COPD, Pulmonary Vascular Disorder
Pulmonary Vasculature and Right Heart Dysfunction in Chronic Obstructive Pulmonay Disease
The pulmonary vasculopathy and right heart dysfunction in COPD are drawing increasing attention these days. Recent researches show that pulmonary vasculopathy and right heart dysfunction relate to greater severity in COPD.
- Conditions
- COPD, Pulmonary Vascular Disorder, Right Ventricular Dysfunction
- Trial name
- NCT03184727
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Neuromuscular Electrical Stimulation as an Adjunct to Exercise Training in Stable Chronic Obstructive Pulmonary Disease (COPD)
Skeletal muscle dysfunction impairs exercise capacity, quality of life and prognosis in chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01658046
- Testing
- Neuromuscular electrical stimulation, Endurance training, Quadriceps strength training
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Hacettepe University
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
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