Clinical trials: Chronic Obstructive Pulmonary Disease Exacerbation
Acute Heart Failure, COPD Exacerbation
Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation
Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis .
- Trial name
- NCT01619540
- Testing
- Valsalva maneuver
- Where
- 4 sites in Tunisia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Asthma, Reactive Airway Disease
Comparison of Oral Dexamethasone Doses in Asthma Exacerbation
Hypothesis: A 2-day course of oral dexamethasone is the superior option for the resolution of symptoms and prevention of relapse in the emergency department (ED) management of mild-moderate asthma exacerbations.
- Trial name
- NCT00942201
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Rady Children's Hospital, San Diego
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
COPD
A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations
This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days.
- Trial name
- DOLE-COPD (NCT06915688)
- Testing
- Doxycycline, Levofloxacin
- Where
- Pakistan
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Amina Aslam
Chronic Obstructive Pulmonary Disease
Substudy : Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Its prevalence is in progression and COPD is expected to become the fourth leading cause of death by 2030.
- Trial name
- EXA (NCT02282436)
- Testing
- No specific intervention for this study
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
COPD Exacerbation
Mast Cells and Its Proteases in COPD
Mast cells proteases such as chymase and tryptase will be studied in the tissue of small and large airways in COPD patients
- Trial name
- NCT06392334
- Testing
- Biopsy
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Voronezh N.N. Burdenko State Medical Academy
Asthma, COPD
Anti-viral Effects of Azithromycin in Patients With Asthma and COPD
The purpose of this study is to investigate the anti-viral effects of low-dose AZM treatment in patients with asthma and COPD with an exacerbation history.
- Conditions
- Asthma, COPD, Exacerbation Copd, Asthma; Eosinophilic
- Trial name
- AZIMUNE (NCT04319705)
- Testing
- Azithromycin
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Chronic Obstructive Pulmonary Disease Exacerbation, COPD
Clinical Trial to Assess Effect of Verapamil on Systemic Exposure of EP395 and Effect of EP395 on Systemic Exposure of Midazolam and Digoxin
The aim of this trial is to assess the potential key drug-drug interactions with EP395 in the clinical setting.
- Trial name
- NCT06118684
- Testing
- EP395 (Part A and B), Verapamil (Part A), Midazolam (Part B)
- Where
- Sweden
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- EpiEndo Pharmaceuticals
COPD, COPD Exacerbation
Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes (IbICEnCa)
We have demonstrated for the very first time that it is possible to isolate CPCs (circulating pulmonary cells) in patients with COPD in a sample of 17 patients (with a recovery rate of nearly 40%) and none of 10 healthy, non…
- Conditions
- COPD, COPD Exacerbation, COPD, Severe Early-Onset
- Trial name
- IbICEnCa (NCT03591978)
- Testing
- Isolation of Circulating Pulmonary Cells in peripheral blood
- Where
- 4 sites in Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
Exhaled Breath Condensate (EBC) Assessment in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
This study aimed to assess airway inflammation in patients during the course of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) by serial analyses of their exhaled breath condensates (EBC).
- Trial name
- NCT00448500
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Obstructive Pulmonary Disease (COPD)
Lung Ultrasound With Acute Exacerbation and Stable COPD
This cross-sectional study aims to compare lung ultrasound findings, functional capacity, and dyspnea among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), patients with stable COPD, and…
- Trial name
- NCT07757126
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Obstructive Pulmonary Disease
Changes in Inflammatory Markers During Pulmonary Rehabilitation Based on Exacerbation States in COPD
This study will examine the inflammatory response to exercise encompassed as part of a standard pulmonary rehabilitation programme in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- CIMPRES-COPD (NCT02740686)
- Testing
- Sample collection
- Where
- 6 sites in United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
The overlap between chronic obstructive pulmonary disease (COPD) and bronchiectasis is a neglected area of research, and it is not covered by guidelines for clinical practice.
- Conditions
- Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease, Overlap, Microbiome
- Trial name
- NCT04865861
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
COPD
Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Molecular mechanisms of COPD exacerbations and the modulating effect of low dose theophylline on that inflammation are elucidated in this project.
- Trial name
- NCT00671151
- Testing
- Theophylline
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Son Dureta
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen