Clinical trials: Chronic Obstructive Pulmonary Disorder, open to volunteers
COPD, Healthy Adult
Shear Wave Elastography of Intercostal Muscles for the Non-invasive Assessment of the Work of BreathinG
Quantifying respiratory effort is a key step in physiological and clinical research on exercise tolerance, mechanisms of fatigability, and ventilatory impairment.
- Trial name
- SWING (NCT07371754)
- Testing
- Intercostal muscle shear wave elastography (SWE) during standardized inspiratory loading
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease
Study on Impact of Maximal Strength Training in Patients With COPD
In the context of pulmonary rehabilitation of COPD patients, recent guidelines and metanalysis describe that Resistance Training (RT) can be successfully performed alone or in conjunction with Endurance Training (ET) without…
- Trial name
- NCT03799354
- Testing
- Maximal strenght training (MST) plus endurance training (ET), Endurance training (ET)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Chronic Obstructive Pulmonary Disease (COPD)
The Effect of Pranayama Practiced With Rain Sounds on Self-Efficacy, Dyspnea, and Respiratory Functions in Patients With COPD
Chronic obstructive pulmonary disease (COPD) ranks third among the leading causes of death worldwide. It causes a variety of symptoms resulting from irreversible obstruction of the airways.
- Trial name
- NCT07820059
- Testing
- pranayama breathing exercises, A group will perform pranayama breathing exercises accompanied by the sound of rain.
- Volunteers
- 114 people
- Sponsor
- Inonu University
Chronic Obstructive Pulmonary Disease (COPD)
Treatment of Chronic Obstructive Pulmonary Disease (COPD) by REGEND007 Cell Therapy
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide with the characterization of obstructed airflow.
- Trial name
- NCT07355868
- Testing
- REGEND007
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Regend Therapeutics
COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations
The REVIVE Pivotal Study
The goal of this study is to test whether a new treatment called the Ryme Medical Targeted Lung Denervation (TLD) Catheter is safe and effective for people with moderate to severe chronic obstructive pulmonary disease (COPD).
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations, COPD Patients, COPD Acute Exacerbation
- Trial name
- REVIVE (NCT07361653)
- Testing
- Ryme TLD
- Volunteers
- 300 people
- Sponsor
- Ryme Medical, Inc.
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Chronic Obstructive Pulmonary Disease (COPD), Severe Asthma
COINCIDE: Cardineurovascular dIsease and Obstructive Airway Disease
Patients with chronic obstructive pulmonary disease (COPD) and severe asthma frequently present with cardiovascular comorbidities that contribute substantially to morbidity and mortality.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Severe Asthma, Cardiovascular Diseases
- Trial name
- COINCIDE (NCT07856667)
- Testing
- Routine Clinical Care
- Volunteers
- 350 people
- Sponsor
- VASCage GmbH
Pulmonary Disease, Chronic Obstructive, Exacerbation Copd
Monitoring of the End-tidal Carbon Dioxide (EtCO2) as a Severity Criterion in COPD Exacerbations
Although we know that these numbers are underestimated, Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease that affects between 8 and 12% of adults.
- Trial name
- CO2PD (NCT05704881)
- Testing
- End-Tidal CO2 measurement during COPD exacerbation
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Grenoble
COPD, Chronic Obstructive Pulmonary Disease
Home-based Pulmonary Rehabilitation for COPD Patients
Objectives The objective of this project is to motivate patients with COPD to incorporate the habit of doing daily mindful physical activity by using the proposed home-based pulmonary rehabilitation program that integrates video…
- Trial name
- NCT04820257
- Testing
- Home based exercise
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
COPD
PEP Buddy in Pulmonary Rehabilitation
In this study, the investigators will test Veterans with COPD in Pulmonary Rehabilitation. Between two groups, the investigators will give one group a device that assists with breathing and symptoms and the other receives a…
- Trial name
- PEPR (NCT07404826)
- Testing
- PEP Buddy
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Pulmonary Disease, Chronic Obstructive
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Depemokimab is being developed as a treatment for individuals with moderate to severe COPD. The aim of this study is to assess the efficacy and safety of depemokimab compared as an add-on medicine in participants with…
- Trial name
- ENDURA-2 (NCT06961214)
- Testing
- Depemokimab
- Where
- 193 sites in United States, Argentina and 14 more
- Volunteers
- 961 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease (COPD)
Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) can affect the small airways and alter respiratory mechanics. Nasal high-flow therapy delivers warmed and humidified gas through nasal cannulas and may change airway resistance.
- Trial name
- NHFlOscillo (NCT07750613)
- Testing
- Heated Humidified Nasal High-Flow Therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- ADIR Association
Respiratory Diseases
Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.
- Trial name
- CHRONOBIO (NCT06366113)
- Testing
- Pulmonary rehabilitation
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Michaël RACODON
COPD Received PR, Elderly (People Aged 65 or More)
Efficacy Of Inpatient Pulmonary Rehabilitation Program In Elderly Patients With Acute Exacerbation Of COPD
The study aimed to identify the effect of early pulmonary rehabilitation in elderly patients with Acute exacerbation (AE) of COPD (AECOPD) in exercise tolerance, dyspnea, sleep quality, fatigue, and time to discharge from…
- Conditions
- COPD Received PR, Elderly (People Aged 65 or More), COPD, COPD Acute Exacerbation
- Trial name
- NCT07020182
- Testing
- physical therapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Chronic Obstructive Pulmonary Disease
Evaluation of the Clinical Trial of Inhaled TQC3721 Suspension in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease
To evaluate the efficacy of TQC3721 Suspension for Inhalation in patients with moderate to severe Chronic obstructive pulmonary disease (COPD)
- Trial name
- NCT07147946
- Testing
- TQC3721 Suspension for inhalation
- Where
- 76 sites in China
- Volunteers
- 666 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Graft-Versus-Host Disease
A Study to Evaluate Adrixetinib (Q702) in Adults With Active Chronic Graft-Versus-Host Disease
Open-label, dose escalation study to evaluate safety, tolerability pharmacokinetic and pharmacodynamic activity, and efficacy of Adrixetinib (Q702) in subjects with relapsed or refractory active chronic graft-versus-host disease…
- Trial name
- NCT07138196
- Testing
- Adrixetinib
- Where
- 8 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Qurient Co., Ltd.
Chronic Obstructive Pulmonary Disease (COPD), Allergies
Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD
This research is being done to test if a drug called omalizumab can help people with Chronic Obstructive Pulmonary Disease (COPD) and allergies.
- Trial name
- COPD-OMA (NCT07059091)
- Testing
- Omalizumab (Xolair®), Sodium Chloride (NaCl) 0.9 %
- Where
- 23 sites in United States
- Volunteers
- 334 people
- Sponsor
- Johns Hopkins University
COPD, COPD (Chronic Obstructive Pulmonary Disease)
Probiotics in COPD: Effects on Symptoms, Lung Function, and Inflammation
The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Probiotic, Probiotic Supplement
- Trial name
- NCT07339280
- Testing
- Probiotic Capsule
- Where
- 5 sites in Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital of Split
Asthma, COPD
Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections.
- Conditions
- Asthma, COPD, Bacterial Pneumonia, Viral Pneumonia
- Trial name
- OXIGENE (NCT07386912)
- Testing
- Characterization of the neutrophil granulocyte epigenome, Characterization of the T-cell immune response to to various oxidatively modified mycobacterial antigens
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Research Center Borstel