Clinical trials: Chronic Opioid Use
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Joint Pain, Chronic Pain
Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty
Personalized medicine is a concept in which medical care is individualized to a patient based on their unique characteristics, including comorbidities, demographics, genetics, and microbiome.
- Conditions
- Joint Pain, Chronic Pain, Opioid Use
- Trial name
- NCT04974463
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Diego
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Opioid Use Disorder, Chronic Pain
Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
This study is a multisite randomized clinical trial of a treatment designed to reduce pain interference while simultaneously addressing relapse prevention among individuals who have co-occurring chronic pain and Opioid Use…
- Trial name
- HOPE (NCT05571917)
- Testing
- Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP), Enhance Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- University of New Mexico
Chronic Pain, Opioid Use
Cognitive Function and Addiction Under Opioid Tapering
This study evaluates the effects of opioid dose reduction in the treatment of chronic pain in adults. Participants were divided in two groups: 1) patients that reduced opioid dose and 2) patients that kept the same opioid dose…
- Trial name
- NCT03365817
- Testing
- Opioids taper off, Opioid stable treatment
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Opioid Use, Pain
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
This hybrid implementation-effectiveness trial will evaluate Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment (MT).
- Trial name
- IMPOWR-MORE (NCT06032559)
- Testing
- MORE, SMP, TAU
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Pain
Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial
The focus of this study is to determine whether adding Whole Health Coaching (WHC) improves pain care among adults with chronic pain and who are currently working with a pain management team (PMT) at the VA.
- Trial name
- TEAMWORK (NCT07149870)
- Testing
- Pain Management Team + Whole Health Coach (PMT-WHC), Pain Management Team-Usual Care (PMT-UC)
- Where
- 5 sites in United States
- Volunteers
- 432 people
- Sponsor
- VA Office of Research and Development
Chronic Pain, Opioid Use
Predicting Chronic Pain Following Breast Surgery
Breast surgery, which includes mastectomy, breast reconstructive surgery, or lumpectomies with sentinel node biopsies, may lead to the development of chronic pain and long-term opioid use.
- Conditions
- Chronic Pain, Opioid Use, Breast Pain, Breast Cancer
- Trial name
- NCT04967352
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, San Diego
Pain, Chronic Pain
Decreasing Long-term Opioid Use in Cancer Survivors
This is a feasibility pilot trial assessing a behavioral intervention for chronic pain among disease-free cancer survivors to decrease long-term opioid dependence.
- Conditions
- Pain, Chronic Pain, Cancer Pain, Survivorship
- Trial name
- NCT05067556
- Testing
- Acceptance and Commitment Therapy for chronic pain (ACT-CP)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Opioid Use Disorder (OUD), Chronic Pain
Mindfulness Texting for Medication Adherence and Chronic Pain Management
The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages based on integrated Acceptance and Commitment Therapy and Mindfulness Based Relapse Prevention (ACT+MBRP) on medication adherence…
- Trial name
- MiMA (NCT07711795)
- Testing
- Mindfulness text messages
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of New Mexico
Pain
Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain
This study aims to evaluate the impact of a Transitional Pain Service (TPS) on hospital readmission rates, opioid consumption, and chronic post-surgical pain(CPSP), Despite increasing recognition of the benefits of integrated…
- Trial name
- NCT07783672
- Testing
- Transitional Pain Service
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Pain, Opioid Use
The Association of Microbiome Patterns With Chronic Opioid Use
The United States is in the midst of an opioid epidemic, with the number of opioid-related deaths having risen six-fold since 1999.
- Trial name
- NCT05304403
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Postoperative Pain, Opioid Use
SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery
This prospective, randomized, assessor-blinded study will compare serratus posterior superior intercostal plane block and erector spinae plane block in adult female patients undergoing unilateral breast surgery.
- Trial name
- SPES-CPSP (NCT07674836)
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Ultrasound-guided Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Engin Çetin
Inflammatory Bowel Diseases
Nabilone Use For Acute Pain in Inflammatory Bowel Disease Patients
This is a clinical trial of nabilone for patients with Inflammatory Bowel Disease (IBD) who are undergoing IBD-related surgery (Any abdominal surgery lasting for more than one hour).
- Trial name
- NCT03422861
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Acute Musculoskeletal Pain, Chronic Pain
The Pain Intervention Via Video Optimization Trial
This project tests a brief evidence-based video to help educate patients regarding effective and safe pharmacologic and non-pharmacologic therapies for acute musculoskeletal pain (MSP).
- Trial name
- PIVOT (NCT06035575)
- Testing
- Educational video
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Pain, Back Pain
CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial
The goal of this clinical trial is to learn whether a combined behavioral and pharmacologic intervention can help reduce opioid use, improve pain recovery, and prevent opioid misuse after surgery in adults undergoing elective…
- Conditions
- Chronic Pain, Back Pain, Neck Pain, Opioid Misuse
- Trial name
- CARES (NCT06027099)
- Testing
- Tizanidine, MI-Opioid Taper, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 375 people
- Sponsor
- Stanford University
Opioid-use Disorder, Pain
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)
The purpose of this pilot trial is to determine the feasibility of integrating exercise and psychotherapy that is specifically targeted to reducing and managing pain into residential drug treatment programs.
- Trial name
- NCT04736550
- Testing
- Exercise, Psychotherapy for Pain (I-STOP)
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Case Western Reserve University
Pain, Chronic Pain
Evaluation of an Opioid Stewardship Program in Non-Cancer Patients
The objective of this prospective, non-randomized clinical trial is to evaluate the effectiveness of a pharmacist-led Opioid Stewardship Program (OSP) in outpatient adults with chronic non-cancer pain.
- Conditions
- Pain, Chronic Pain, Opioid Analgesia, Opioid Use
- Trial name
- NCT07102446
- Testing
- Opioid Stewardship Program
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Korea University Guro Hospital
Back Pain
The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study
The investigators will conduct a pilot cluster randomized controlled trial (RCT) of chiropractic care added to usual medical care, versus usual medical care alone, for adult patients prescribed opioid therapy for chronic…
- Trial name
- ACCESS-DC (NCT06160947)
- Testing
- Usual Medical Care, Usual Medical Care + Chiropractic Care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University