Clinical trials: Chronic Periodontitis
Root Canal Treatment, Intracanal Medicament
The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments
Previously untreated, asymptomatic, single-rooted maxillary anterior teeth with periapical lesions <5 mm, no fractures, resorption, calcification, or recent antibiotic use will performed two-visit root canal treatment.
- Conditions
- Root Canal Treatment, Intracanal Medicament, Post Operative Pain, Apical Periodontitis
- Trial name
- NCT07210177
- Testing
- Bio-C Temp Intracanal Medication, Metapaste Intracanal Medication
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Chronic Periodontitis
1% Metformin Gel in the Treatment of Class II Furcation Defects
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone.
- Trial name
- NCT02580331
- Testing
- SRP and 1% metformin
- Where
- India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Efficacy of Locally Delivred 1.2% Rosuvastatin Gel in Chronic Periodontitis
BACKGROUND: Chronic periodontitis (CP) is an inflammatory condition affecting tooth supporting tissues and alveolar bone that surround the tooth leading to formation of deepend gingival sulcus that is highly prone to pathologic…
- Trial name
- NCT02283515
- Testing
- Rosuvastatin
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Apical Periodontitis, Retreatment
Biomarkers in Apical Periodontitis
Aim: To evaluate the effects of three different irrigation activation techniques-conventional syringe irrigation (CSI), ultrasonic irrigation (UI), and SWEEPS (Shock Wave Enhanced Emission Photoacoustic Streaming)-on the levels…
- Conditions
- Apical Periodontitis, Retreatment, Biomarkers, Cytokine
- Trial name
- NCT07504861
- Testing
- laser activation, PUI, CSI
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Chronic Periodontitis
Combined Use of Er:YAG and Nd:YAG Laser
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
- Trial name
- NCT02851823
- Testing
- Periodontal curettes, Er-YAG+Nd-YAG lasers
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Chronic Periodontitis, Aggressive Periodontitis
Nitro-oxidative Stress in Periodontitis
Periodontitis is a chronic inflammatory disease whose etio-pathogencity is not fully understood yet. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in physiological and pathological processes.
- Trial name
- NCT02127203
- Where
- Syria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damascus University
Thyroid Diseases, Chronic Periodontitis
Thyroid Disease and Chronic Periodontitis
Currently, the investigators are unaware of any previous studies that have analyzed the relationship between the prevalence of thyroid disease and chronic periodontitis among adults utilizing a retrospective, cross-sectional…
- Trial name
- NCT03369405
- Testing
- NO intervention, patient records review only
- Where
- United States
- Volunteers
- 4,965 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Periodontal Diseases, Chronic Periodontitis
Photodynamic Therapy During Supportive Periodontal Therapy
27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites.
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT02666573
- Testing
- Fotosan 630, CMS Dental, Copenhagen, Denmark, Scaling and root planing
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Periodontal Regeneration
Amnion Chorion Membrane Combined With Allograft Bone Putty for the Management of Intrabony Defects
The ultimate goal for periodontal management is to obtain true periodontal regeneration. Periodontal regeneration implies that CAL gain is achieved through the formation of new cementum and new inserted periodontal ligaments…
- Trial name
- NCT05922527
- Testing
- Combined regenerative technique, Open flap debridement
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periodontitis, Chronic Kidney Disease
Impact of Non Surgical Periodontal Therapy on Cystatin C Levels
Study the effect of non-surgical periodontal therapy on cystatin C levels in gingival crevicular fluid and serum in both healthy patients and patients with renal impairment.
- Trial name
- NCT07103421
- Testing
- Non-Surgical Periodontal Therapy
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Latakia University
Periodontal Inflammation
The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy in Different Age Groups
the summary is to evaluate The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitrous Oxide Synthase Salivary Levels in Different Age Groups of Chronic Periodontitis Patients
- Trial name
- NCT06140394
- Testing
- diode laser, non surgical scaling
- Where
- 2 sites in Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Chronic Periodontitis (Disorder)
Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis
To assess the association between periodontal parameters, serum lipid profile and Lp-PLA2 level in systemically healthy Chronic Periodontitis subjects and healthy controls.
- Trial name
- NCT03041480
- Testing
- serum lipid levels and Lp-PLA2
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis, Adult
Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy
The aim of the study is to evaluate the efficacy of proanthocyanidins as an adjunctive periodontal therapy in patients with periodontitis. Recently proanthocyanidins were proposed as a viable adjunct to periodontal treatment.
- Trial name
- NCT05015387
- Testing
- Minimally invasive non-surgical therapy, Subgingival application of collagen hydrogels with proanthocyanidins, Collection of saliva samples
- Where
- Lithuania
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Periodontitis, Diabetes Mellitus
Effects of Gum Disease Treatment on Host Defense Factors
Human immune system produces many different factors, which will influence health-disease statuses. This partially explains why under similar conditions only some people become sick.
- Trial name
- PETREBED (NCT03146975)
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Chronic Periodontitis, Bacteremia
Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy
There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment.
- Trial name
- AMX-Perio (NCT03354338)
- Testing
- Amoxicillin
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Chronic Periodontitis With Mandibular Degree 2 Furcation Defects
Boric Acid in Degree 2 Furcation Defect
The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic…
- Trial name
- NCT02738515
- Testing
- 0.75 % Boric Acid
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Diseases
Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation
Non-surgical treatment of chronic periodontitis with vitamin E and coenzyme Q10 supplementation
- Trial name
- NCT06373848
- Testing
- Receive 30 mg of Coq10
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Periodontitis
Diode Laser and SRP in Chronic Periodontitis
The purpose of this study is to compare the efficacy of photoablative and photodynamic diode laser in adjunct to scaling-root planing (PAPD+SRP) and SRP alone for the treatment of periodontitis.
- Trial name
- PAPD (NCT02407379)
- Testing
- PAPD+SRP
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Odontostomatologic Laser Therapy Center, Florence, Italy
Periodontal Regeneration
Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect
Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each.
- Trial name
- RCT (NCT04786327)
- Testing
- Minimal invasive flap technique, Minimally invasive flap with root conditioning (EDTA) and platelet rich fibrin, minimally invasive flap with root contioning by EDTA and growth factor enhanced matrix GEM21S
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tanta University