Clinical trials: Chronic Periodontitis
Chronic Periodontitis
Effect of a Locally Delivered Probiotic in Periodontitis
Saccharomyces boulardii is commonly employed as a live non-pathogenic probiotic microbial feed or food supplement. S. boulardii reduces the secretion of key pro inflammatory cytokines and promotes the production of…
- Trial name
- NCT02645669
- Testing
- Study site, Control site
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Chronic Apical Periodontitis
Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste
This study aimed to evaluate the efficacy of N-acetylcysteine (NAC) used as an intracanal medicament on antibacterial activity, periapical RANKL/OPG ratio, and postoperative pain levels.
- Trial name
- NCT07340944
- Testing
- N Acetyl Cysteine, Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Chronic Periodontitis
Utilization of a Videoscope in Periodontal Regeneration
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS).
- Trial name
- NCT05275192
- Testing
- Videoscope-assisted periodontal regeneration minimally invasive surgery, Periodontal regeneration minimally invasive surgery, Guided tissue regeneration surgery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Chronic Periodontitis
Efficacy of Turmeric in Gingival Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patient
Periodontal disease is considered as inflammatory, multifactorial, and threshold disease accompanied by destruction of periodontium and eventually the loss of natural teeth.
- Trial name
- NCT02890771
- Testing
- Tooth Brushing with Dentifrice, Turmeric Massaging, SRP with turmeric massaging
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Government College of Dentistry, Indore
Non-steroidal Anti-inflammatory Poisoning
Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic…
- Trial name
- NCT02658799
- Testing
- cataflam (diclofenac potassium)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Baskent University
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Dental Pulp Necrosis, Periapical Periodontitis
Measurement of Bite Force in Humans
This protocol is for a clinical trial to evaluate the reliability of the bite fork as a diagnostic instrument in subjects with pulpal necrosis and apical periodontitis.
- Trial name
- NCT00223327
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
HIV/AIDS, Periodontal Diseases
Effects of Periodontal Treatment on HIV-infected Patients
Periodontal diseases, such as chronic periodontitis (CP), frequently occur in immunosuppressed patients, including HIV-infected patients.
- Trial name
- NCT03262402
- Testing
- Basic periodontal treatment
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis Chronic Localized Slight
Locally Delivered Whey Protein Nanoparticles Gel in Stage II Grade B Periodontitis
Aim of the current study is to evaluate radiographic and clinical alterations following topical application of CWP gel and CWP nanoparticles gel in stage II grade B periodontitis patients.
- Trial name
- NCT06401798
- Testing
- CWP gel, NCWP gel
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Chronic Periodontitis
Probiotics Effects to Initial Periodontal Treatment
The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.
- Trial name
- NCT05408364
- Testing
- probiotic or natural yoghurt, SRP
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Chronic Periodontitis
Comparison of Rosuvastatin With Atorvastatin in Chronic Periodontitis
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical and radiographic efficacy of two local drug delivery systems containing 1.2% RSV gel and 1.2% ATV gel in…
- Trial name
- NCT02600520
- Testing
- SRP with RSV gel LDD, SRP with ATV gel LDD
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Periodontitis
Single Session Of Antimicrobial Photodynamic Therapy Using Indocyanine Green
In recent years, there has been a growing interest in the use of dental lasers for treatment of periodontal diseases. Commercially available photodynamic therapy for periodontal diseases utilizes methylene blue as a…
- Trial name
- NCT02043340
- Testing
- indocyanine green, LASER, Scaling and Root Planing
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Head and Neck Cancer, Chronic Periodontitis
suPAR is a Potential Biomarker of in Chronic Periodontitis Through the Impact of Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy; Complications
- Trial name
- HNCs (NCT06481059)
- Testing
- Head and Neck cancer post-radiotherapy
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Chronic Periodontitis, Occlusal Trauma
Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma
Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.
- Trial name
- NCT03621891
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Intrabony Defect, Intrabony Defects in Chronic Periodontitis
Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
- Trial name
- NCT07261878
- Testing
- injectable platelet rich fibrin and xenograft, Xenograft alone
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Periodontitis, Psoriasis
Evaluation of Salivary and Serum Levels of TNF-α, IL-17A, and YKL-40 in Individuals With Psoriasis
Background: Periodontitis is a chronic inflammatory disease triggered by microbial infections that lead to the destruction of tissues supporting the teeth.
- Trial name
- NCT06984237
- Testing
- TNF-α Analysis in saliva, IL-17A analysis in saliva, YKL-40 Analysis in saliva
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Chronic Periodontitis
Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis
Periodontal disease is an immune-inflammatory disease which consists of connective tissue breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an equilibrium maintained between reactive oxygen…
- Trial name
- NCT03533972
- Testing
- Ashwagandha
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College