Clinical trials: Chronic Post-operative Pain
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete
Quality of Life, Living-donor Liver Transplantation
The Effect of Individualised Pain Education on Chronic Postoperative Pain Development and Quality of Life in Living Liver Donors
Chronic postoperative pain is defined as pain that is a continuation of acute pain or develops after a pain-free period, is localised to the surgical site, affects quality of life, and persists for at least 3 months after surgery…
- Conditions
- Quality of Life, Living-donor Liver Transplantation, Chronic Post Operative Pain, Pain Management
- Trial name
- NCT06609772
- Testing
- Individualised Pain Education
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Nazlican Bagci
Arrythmia, Chronic Pain
Acute and Chronic Pain After One-stage Hybrid Arrhythmia Ablation Surgery
After one-stage hybrid arrhythmia ablation surgery there are possible side effects like acute and chronic pain. There is a lot of research surrounding these pains but not specifically after one-stage hybrid arrhythmia ablation…
- Conditions
- Arrythmia, Chronic Pain, Acute Pain, Post Operative Pain
- Trial name
- NCT05211492
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- Universitair Ziekenhuis Brussel
Pain, Postoperative, Pain, Acute
Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries
The aim of this study will be to compare the effects of morphine versus dexmedetomidine when used as adjuvants to local anesthetic (Ropivacaine) in Erector Spinae Plane Block under ultrasound guidance.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Morphine
- Trial name
- NCT05843344
- Testing
- erector spinae plane block with a combination of ropivacaine and morphine, erector spinae plane block with a combination of ropivacaine and dexmedetomidine, erector spinae plane block with ropivacaine only
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Dr Kassiani Theodoraki
Phantom Limb Pain After Amputation, Lower Limb Amputation
Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation
The study will investigate the application of a non-pharmacological operant conditioning approach to reduce phantom limb pain (PLP). PLP afflicts 60-90% people who have lost a limb.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain
- Trial name
- OCS-PLP (NCT05880251)
- Testing
- Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Inguinal Hernia
Safety and Effectiveness of Optomesh 3D for Inguinal Hernia Repair
OPTIMUS is an observational study assessing the safety and effectiveness of Optomesh 3D, a shaped surgical mesh used in planned keyhole surgery for a groin (inguinal) hernia.
- Trial name
- OPTIMUS (NCT07836179)
- Testing
- Optomesh 3D
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Swissmed Hospital
Pain, Chronic, Pain, Neuropathic
Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic Pain
Prospective multicentric observational trial on caregiver burden, caregiver satisfaction and clinical outcome in spinal cord stimulation for chronic neuropathic pain.
- Conditions
- Pain, Chronic, Pain, Neuropathic, Failed Back Surgery Syndrome
- Trial name
- CAREstim (NCT04737746)
- Where
- 2 sites in Belgium
- Volunteers
- 42 people
- Sponsor
- AZ Delta
Pain, Post Operative Pain
Patient Reported Outcomes, Postoperative Pain and Pain Relief After Day Case Surgery (POPPY)
Around 3 out of 4 operations in the UK are performed as day-case, meaning the patient goes home on the same day of their operation.
- Conditions
- Pain, Post Operative Pain, Opioid Use, Chronic Pain
- Trial name
- POPPY (NCT06008496)
- Testing
- Day case surgery
- Where
- United Kingdom
- Volunteers
- 7,839 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Chronic Pain
Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair
The effect of intraoperative infiltration of the operation site with bupivacain on the development of chronic pain is the object of our trial.
- Trial name
- NCT00484731
- Testing
- Infiltration with Saline, Infiltration with Bupivacaine
- Where
- Switzerland
- Volunteers
- 404 people
- Sponsor
- Luzerner Kantonsspital
Acute Pain, Chronic Postsurgical Pain
The Influence of Different Anesthesia on Acute and Chronic Postsurgical Pain After Thoracic Surgery
This study would compare acute and chronic postsurgical pain in patients underwent thoracic surgery with different anesthesia and analgesia methods, and explore the influencing factors.
- Trial name
- NCT03847363
- Testing
- epidural anesthesia, nerve block
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Kidney Diseases, Post Operative Pain
Methadone Pharmacokinetics in End-stage Renal Disease
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the management of acute…
- Conditions
- Chronic Kidney Diseases, Post Operative Pain, Pain, Acute
- Trial name
- MCKD (NCT06056245)
- Testing
- Preoperative step, Intraoperative, Post-operative
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Phantom Limb Pain, Chronic Pain
Prevention of Phantom Limb Pain After Transtibial Amputation
Phantom limb pain following amputation is a major problem. Current evidence how to best prevent phantom limb pain is equivocal because previous trials have included small numbers of patients, and tested heterogeneous patient…
- Conditions
- Phantom Limb Pain, Chronic Pain, Prevention
- Trial name
- PLATA (NCT01626755)
- Testing
- Sciatic name block
- Where
- 9 sites in United States, Austria and 3 more
- Volunteers
- 12 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cerebral Palsy, Post-operative Pain
The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Cerebral palsy is common. It affects approximately 3 per 1000 children. Hip displacement due to muscle tightness (spasticity) occurs in up to half of the more severely affected children, and many of these children require major…
- Trial name
- POPPIES (NCT01437644)
- Testing
- botulinum toxin intramuscular injection
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cancer, Pain
PECBLOCK for the Treatment of Pain After Breast Surgery
Pain after breast cancer surgery could be severe and about 1/3 of patients will develop chronic pain. The PECBLOCK is the injection of local anesthetics between the two pectoral muscles to block pectoral nerves and intercostal…
- Trial name
- PECBLOC (NCT01670448)
- Testing
- PECBLOCK under echoguidance
- Where
- 2 sites in Canada, France
- Volunteers
- 128 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Chronic Postoperative Pain
Help With Early Detection of Postoperative Neuropathic Pain Using SMS After Ambulatory Surgery
Chronic post-operative pain is generally defined by persistent pain more than 2 months after surgery. General reviews on chronic post-operative pain describe an overall incidence of 30%, of which 5 to 10% are described as severe.
- Trial name
- SMS DPpostop (NCT04313855)
- Testing
- SMS in the early detection of postoperative neuropathic pain
- Where
- France
- Volunteers
- 306 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Phantom Limb Pain, Pain, Chronic
Continuous Sciatic Nerve Block vs Epidural Analgesia in Lower Limb Amputation for Postoperative Pain
Controlled clinical trial of two parallel groups, with random assignment 1:1, non-inferiority, blinded for the patient, for who administers the intervention and for who analyzes the data. 112 participants
- Trial name
- Ampupain (NCT05608733)
- Testing
- Epidural catheter, Continuous sciatic nerve block
- Where
- Colombia
- Volunteers
- 112 people
- Sponsor
- Universidad de Antioquia
Breast Cancer
Paravertebral Block and Reduction in Opioid Consumption After Mastectomy
This prospective randomized study evaluates the efficacy of paravertebral block in reducing opioid consumption during mastectomy and its impact on acute and chronic postoperative pain.
- Trial name
- BPV-MAST (NCT07817797)
- Testing
- Paravertebral Block, Multimodal Analgesia
- Where
- Tunisia
- Volunteers
- 40 people
- Sponsor
- University Tunis El Manar
Spinal Stenosis Lumbar, Surgical Site Infection
Efficacy of ActiveMatrix on Spinal SSI Rate
This clinical trial seeks to provide high level of evidence on the efficacy of ActiveMatrix primarily on spinal surgical site infection rate.
- Conditions
- Spinal Stenosis Lumbar, Surgical Site Infection, Back Pain Lower Back Chronic
- Trial name
- NCT05297513
- Testing
- ActiveMatrix
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Pain, Postoperative
TEMporal PostOperative Pain Signatures
The purpose of this research study is to determine what causes pain after surgery to increase or decrease over time.
- Trial name
- TEMPOS (NCT02407743)
- Testing
- Surgical patients' clinical progression, Genetic markers
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- University of Florida
Breast Cancer, Chronic Pain
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking.
- Conditions
- Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
- Trial name
- B-CAPP (NCT03408717)
- Testing
- Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment
- Where
- 2 sites in United States, Singapore
- Volunteers
- 220 people
- Sponsor
- KK Women's and Children's Hospital