Clinical trials: Chronic Post-operative Pain
Scar, Cesarean Section; Dehiscence
A Comparison of Scar Infiltration, Scar Deactivation, and Standard of Care for the Treatment of Chronic, Post-Surgical Pain After Cesarean Section
To compare scar infiltration with 0.5-1% Lidocaine at a dose of 3 mg/kg (max dose 300 mg) or scar deactivation with acupuncture surface release technique to determine which is more effective in reducing pain in adult patients…
- Trial name
- NCT03936309
- Testing
- Scar Deactivation Surface Release Technique protocol, Scar Infiltration with 0.25-1% Lidocaine, Physical therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jennifer Loomis
Breast Cancer, Chronic Pain
Can Chronic Post-surgical Pain be Reduced by Preserving Intercostobrachial Nerve During Axillary Lymph Node Dissection? : A Randomized Controlled Trial
Intercostobrachial nerve (ICBN) is a cutaneous nerve that provides sensation to the lateral chest, upper medial arm and axilla. It arises from the second intercostal nerve and leave intercostal space at the level of midaxillary…
- Conditions
- Breast Cancer, Chronic Pain, Intercostobrachial Nerve Injury
- Trial name
- PAINE (NCT05198622)
- Testing
- Intercostobrachial Nerve Preserving Axillary Lymph Node Dissection, Intercostobrachial Nerve Sacrificing Axillary Lymph Node Dissection
- Where
- Pakistan
- Volunteers
- 182 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Chronic Pain, Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Pain in Chronic Pain Patients Undergoing Spinal Surgery
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic…
- Trial name
- NCT02752477
- Testing
- Opioid-free general anesthetic, Traditional general anesthetic
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ben Lim
Cholecystitis, Cholecystitis, Acute
TAP Block vs External Oblique Plane Block for Laparoscopic Cholecystectomy Surgery
Ultrasound (US) guidedTransversus Abdominis Plane Block (TAPB) is performed by injecting a local anesthetic into the plane between the internal oblique and transverse abdominis muscles and provides analgesia in the anterolateral…
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic
- Trial name
- NCT06178757
- Testing
- TAPB, EOIB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Endometriosis, Chronic Pelvic Pain
The Effect of Preoperative Pelvic Floor Physical Therapy (Prehabilitation) on Postoperative Pain Following Endometriosis Surgery: A Randomized Controlled Trial
Endometriosis is a chronic inflammatory condition where there is abnormal tissue growing in the pelvis or other places in the body that resembles the lining of the uterus (endometrium), and is a common cause of long lasting…
- Trial name
- NCT07827794
- Testing
- Structured pre-operative pelvic floor physiotherapy program (prehabilitation)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Chronic Post-surgical Pain, Acute Postoperative Pain
CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment
Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization.
- Conditions
- Chronic Post-surgical Pain, Acute Postoperative Pain, Cardiac Surgery
- Trial name
- CROPS (NCT07629453)
- Testing
- Standard Multimodal Opioid-Based Analgesia, Regional Anesthesia-Based Analgesia
- Volunteers
- 180 people
- Sponsor
- Kočan Ladislav
Pain, Postoperative, Chronic Pain
Online Mindfulness-based Intervention to Prevent Chronic Pain
Cardiac and orthopedic surgeries are frequent procedures. However, pain after a major surgery may become chronic (lasting >3 months) in adults.
- Conditions
- Pain, Postoperative, Chronic Pain, Pain Catastrophizing, Pain, Acute
- Trial name
- NCT04848428
- Testing
- Online mindfulness-based cognitive therapy, Online standardized education
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Florida State University
Breast Cancer, Pain
Chronic Pain in Women Who Have Undergone Surgery for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Learning about chronic pain in women who have undergone surgery for breast cancer may help improve the quality of life for these patients and may help doctors plan the best treatment.
- Conditions
- Breast Cancer, Pain, Perioperative/Postoperative Complications
- Trial name
- NCT00971919
- Testing
- questionnaire administration, assessment of therapy complications, psychosocial assessment and care
- Where
- United Kingdom
- Volunteers
- 284 people
- Sponsor
- Aberdeen Royal Infirmary
Post Operative Pain
Combined Supraclavicular Block and General Anesthesia in Pediatric Patients With Chronic Kidney Disease
compare the safety and efficacy of ultrasound-guided supraclavicular block in addition to general anesthesia in pediatric patients undergoing upper limb superficialization of arteriovenous fistula for hemodialysis.
- Trial name
- NCT05580094
- Testing
- general anesthesia only., general anesthesia plus supraclavicular block.
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Assiut University
Chronic Postoperative Pain, Cesarean Section Complications
Monocentric Observational Study: Postoperative Pain After Cesarean Section: Incidence and Risk Factors.
The purpose of this prospective study was to assess chronic pain 3, and 12 months after cesarean delivery in a cohort of women in University hospital La Paz.
- Trial name
- NCT04280432
- Testing
- CESAREAN
- Where
- Spain
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Thoracotomy, Chronic Pain
Sensory Changes From Chest Drains
Does chest drains contribute to the post thoracotomy pain syndrome
- Trial name
- NCT01274871
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Postoperative, Pain, Acute
Dexmedetomidine and Morphine as Adjuvants to US Guided Erector Spinae Plane Blocks in Elective Thoracic Surgeries
The aim of this study will be to compare the effects of morphine versus dexmedetomidine when used as adjuvants to local anesthetic (Ropivacaine) in Erector Spinae Plane Block under ultrasound guidance.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Morphine
- Trial name
- NCT05843344
- Testing
- erector spinae plane block with a combination of ropivacaine and morphine, erector spinae plane block with a combination of ropivacaine and dexmedetomidine, erector spinae plane block with ropivacaine only
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Dr Kassiani Theodoraki
Gallbladder Disease, Biliary Colic
Fluorescence Imaging on the da Vinci Surgical System for Intra-operative Near Infrared Imaging of the Biliary Tree (up to 2-weeks Post-operatively)
The investigators hypothesize that the da Vinci Fluorescence Imaging Vision System provides real-time endoscopic near infrared fluorescence imaging of the biliary anatomy as defined as identifying biliary vessels; either cystic…
- Conditions
- Gallbladder Disease, Biliary Colic, Gallstones
- Trial name
- NCT01410734
- Testing
- Indocyanine green (ICG)
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 72 people
- Sponsor
- Intuitive Surgical
Pain, Postoperative, Hip Pain Chronic
PENG Block Versus LP Block for THA Postop Pain
The purpose of this randomized, double blinded, prospective study is to compare the postoperative analgesia provided by the PENG block to that provided by the LPB for patients undergoing primary anterior approach THA.
- Trial name
- NCT05261009
- Testing
- Peri-capsular Nerve Group (PENG), Lumbar Plexus Block (LPB)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Wake Forest University Health Sciences
Sexual Dysfunction, Hernia, Inguinal
Pain Related Sexual Dysfunction After Laparoscopic Inguinal Hernia Repair
Previous studies have reported that about 3 % of patients who have had open inguinal herniorrhaphy had a visceral, ejaculatory-related pain.
- Conditions
- Sexual Dysfunction, Hernia, Inguinal, Other Chronic Postoperative Pain
- Trial name
- NCT01086007
- Where
- Denmark
- Volunteers
- 1,172 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain, Cerebral Palsy
Popliteal Block for Postoperative Pain in Knee-ankle Soft Tissue Surgery in Cerebral Palsy
Popliteal block is a technique for providing postoperative pain management in children. In this randomized double-blinded study, the investigators evaluated the effects of preoperative popliteal nerve block on postoperative pain…
- Trial name
- NCT02507700
- Testing
- Popliteal block, Sevoflurane, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Hyperalgesia, Pain
Local Anesthetic Infusion and Sternotomy
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy.
- Trial name
- CARDIODOLAL (NCT00802048)
- Testing
- Local anesthetic (Ropivacaine), Saline
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Acute Postoperative Pain
Effects of tDCS and VNS on Postoperative Analgesia
This study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general…
- Trial name
- NCT06554067
- Testing
- Active transcranial direct current stimulation, Active vagus nerve stimulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University