Clinical trials: Chronic Post-operative Pain
Cardiac Anaesthesia, Chronic Pain
Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery
The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing…
- Conditions
- Cardiac Anaesthesia, Chronic Pain, Post Operative Pain, Chronic, Post Operative Pain, Acute
- Trial name
- NCT07490457
- Testing
- Ketamine group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa City Hospital
Phantom Limb Pain
Study of Phantom Limb Pain Suppression Using Neuromodulation Methods
This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral…
- Trial name
- NCT06644807
- Testing
- Motor Cortex Stimulation, Spinal cord stimulation, Peripheral Nerve Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Ambulatory Surgery, Children, Only
Anxiety and Chronic Postsurgical Pain Following Ambulatory Surgery in Children
Prospective, monocentric, observationnal study. The primary objective of this study is to identify if presurgical child or/and parental anxiety is predictive of chronic postsurgical pain in abdominal or urologic ambulatory…
- Conditions
- Ambulatory Surgery, Children, Only, Inguinal Hernia, Umbilical Hernia
- Trial name
- ANXIDOU (NCT04206956)
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Breast Cancer
Paravertebral Block and Reduction in Opioid Consumption After Mastectomy
This prospective randomized study evaluates the efficacy of paravertebral block in reducing opioid consumption during mastectomy and its impact on acute and chronic postoperative pain.
- Trial name
- BPV-MAST (NCT07817797)
- Testing
- Paravertebral Block, Multimodal Analgesia
- Where
- Tunisia
- Volunteers
- 40 people
- Sponsor
- University Tunis El Manar
Lung Cancer(Primary, Metastatic), Benign Lung Mass Requiring Operation
The Impact of Intraoperative Systemic Lidocaine Infusion on Chronic Postoperative Pain After Video-assisted Thoracic Surgery (VATS)
Systemic lidocaine infusion may improve the patients' chronic post surgical pain after video-assisted thoracic surgery
- Trial name
- NCT02006966
- Testing
- Systemic intravenous lidocaine infusion, Normal saline infusion
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Yonsei University
Chronic Postoperative Pain
Pain Control Following Total Hip Arthroplasty
Total hip arthroplasty (THA) is one of the most common surgical procedures performed in elderly patients, with its main indication being end-stage osteoarthritis of the hip1.
- Trial name
- NCT05062356
- Testing
- Bupivacaine Hydrochloride 0.25% Injection Solution_#2, EPINEPHrine 1:200,000 / Prilocaine HCl 4 % 1.8 ML Cartridge, Bupivacaine Hydrochloride 0.5% Injection Solution_#2
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- St. Mary's Research Center, Canada
Chronic Apical Periodontitis
Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain
Successful endodontic treatment depends on effective elimination of microorganisms from the infected root canal system and prevention of reinfection.
- Trial name
- NCT07892690
- Testing
- Cyperus articulatus
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Chronic Postoperative Pain, Pediatric ALL
Chronic Postsurgical Pediatric Pain. Evaluation Risk Factors to Develop Chronic Postsurgical Pain in Children and Adolescents Undergoing Surgery in a First Level Hospital
Chronic postsurgical pain had number of prevalence on 20%. Its derivates from risk factors, but recent research provide new potential risk factors to develop chronic postsurgical pediatric pain.
- Trial name
- NCT04735211
- Testing
- Surgery
- Where
- Spain
- Volunteers
- 260 people
- Sponsor
- Guillermo Ceniza Bordallo
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04858711
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Chronic Postoperative Pain, Open Heart Surgery
Comparison of IV Analgesia, Thoracic Epidural Analgesia, and ESP Block for Chronic Pain After Open Heart Surgery
This prospective observational study aims to compare three routinely used postoperative analgesia techniques in patients undergoing open heart surgery: intravenous analgesia, thoracic epidural analgesia (TEA), and bilateral…
- Conditions
- Chronic Postoperative Pain, Open Heart Surgery, Postoperative Analgesia, Analgesia
- Trial name
- TEA-ESPB-IV (NCT07257744)
- Testing
- Intravenous Analgesia, Thoracic Epidural Analgesia (TEA), Erector Spinae Plane Block (ESPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Karadeniz Technical University
Failed Back Surgery Syndrome
Improvement of Gait by Spinal Stimulation in Patients With Postoperative Chronic Lumbosciatalgia: Pilot Study (GaitStim)
The purpose of this study is to explore the changes in objective walking parameters induced by medullary stimulation in patients with Fail Back Surgery Syndrome, after chronic stimulation, in comparison with preoperative…
- Trial name
- GAITSTIM (NCT05857696)
- Testing
- walking quantified analysis
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Postoperative Pain, Lumbar Surgery
Retrolaminar Analgesia for LuMbar Surgery
This randomized controlled trial evaluates the effectiveness of ultrasound-guided retrolaminar nerve block in addition to standard multimodal analgesia for postoperative pain management in patients undergoing lumbar spine…
- Conditions
- Postoperative Pain, Lumbar Surgery, Back Pain Lower Back Chronic, Opioid Analgesia
- Trial name
- REALM (NCT07334288)
- Testing
- Ultrasound-Guided Retrolaminar Block, Standard Analgesia
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- Universidad de los Andes, Chile
Failed Back Surgery Syndrome
Clinical Evaluation of Direct Dorsal Column Stimulation
The study will examine the feasibility of Direct Dorsal Column Stimulation using existing Stimulation Leads (Ad-Tech). Secondary endpoints will include pain relief, somatosensory evoked potentials (SSEPs), stimulator settings…
- Trial name
- DDCS (NCT02020460)
- Testing
- Subdural trial lead, Epidural trial lead
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete
Postoperative Pain, Postoperative Pain, Acute
Incidence of Chronic Pain After Thoracic Surgery
Thoracotomy and video-assisted thoracic surgery procedures are frequently performed in thoracic surgery. It is widely accepted that thoracotomy causes severe acute pain.
- Conditions
- Postoperative Pain, Postoperative Pain, Acute, Postoperative Pain, Chronic, Video-Assisted Thoracoscopic Surgery
- Trial name
- NCT05145153
- Testing
- Thoracic surgery application
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Post-Operative Pain, Chronic, Necrotic Pulp
Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp
Propolis is a resinous product of honeybees. Propolis is said to be effective against resistant microorganisms inside the root canal compared to the gold standard medication known as calcium hydroxide.
- Trial name
- NCT04983524
- Testing
- propolis, Calcium Hydroxide
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Chronic Pain
Sensory Abnormalities in Post-surgical Peripheral Neuropathy
The concept of normality is a cornerstone in medical practice and research. As an example, in clinical chemistry, a laboratory value based on a plasma sample exceeding the +/- 1.96 x standard deviation (SD) range, referenced from…
- Trial name
- NCT03966677
- Where
- Denmark
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Chronic Postsurgical Pain, Acute Pain
Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery
Studies evaluating postoperative pain as a risk factor for CPSP are almost exclusively carried out in the context of scheduled surgery.
- Conditions
- Chronic Postsurgical Pain, Acute Pain, Emergency Surgery, Opioid
- Trial name
- POCSE (NCT06555107)
- Testing
- questionnaire, phone call
- Where
- France
- Volunteers
- 693 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University