Clinical trials: Chronic Post-operative Pain
Breast Cancer
The Effect of Ultrasonography-guided Fascial Plane Blocks in Breast Cancer Surgery Patients
The aim of this study was to evaluate the efficacy of serratus anterior plane (SAP) block, pectoserratus plane (PECS II) block, and erector spinae plane (ESP) block on postoperative acute pain, quality of recovery and chronic…
- Trial name
- NCT06419504
- Testing
- SAP block group, PECS II block group, ESP block group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Antalya Training and Research Hospital
Pain, Phantom, Pain, Neuropathic
Valproic Acid for the Prevention of Post-Amputation Pain
The objectives of this study are, to test the effectiveness of Valproic Acid (VPA) in the prevention of chronic neuropathic and post-amputation pain, as well as to further define the underlying inflammatory and epigenetic…
- Trial name
- NCT01928849
- Testing
- Valproic Acid, Cherry Syrup
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Chronic Apical Periodontitis
Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth
The goal of this clinical trial is to learn whether regenerative endodontic treatment (RET) should be performed in one visit or two visits in people with mature permanent teeth with chronic apical periodontitis.
- Trial name
- NCT07480226
- Testing
- Single-Visit Regenerative Endodontic Treatment, Multiple-Visit Regenerative Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Marmara University
Inguinal Hernia, Inguinal Hernia Repair
TransREctus Sheath PrePeritoneal Procedure (TREPP) for Inguinal Hernia Repair
Inguinal hernia repair remains one of the most commonly performed surgical procedures worldwide. Tension-free repair with mesh augmentation is the predominant treatment option, either achieved by preperitoneal laparoscopic…
- Trial name
- NCT07618884
- Testing
- trans rectus sheath extra-peritoneal procedure (TREPP)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Pain, Chronic, Pain, Chronic Post-Surgical
iCanCope With Post-Operative Pain (iCanCope PostOp)
There are few applications available in the community to help teenagers manage pain after surgery. The focus of this study is to better understand the pain experience of children after having surgery and to design a Smartphone…
- Trial name
- NCT05382962
- Testing
- iCanCope Post Op Application
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Lumbar Spine Surgery, Chronic Low-back Pain
Telehealth Mindfulness After Spine Surgery
The goal of this pilot clinical trial is to compare two behavioral interventions for patients who are recovering from lumbar spinal surgery for a degenerative spine condition. The study aims to answer the following questions: 1.
- Conditions
- Lumbar Spine Surgery, Chronic Low-back Pain, Postsurgical Pain
- Trial name
- NCT05698914
- Testing
- Telehealth mindfulness-based intervention (MBI), Telehealth Education
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Breast Neoplasms, Pain, Postoperative
Persistant Post-mastectomy Pain in Breast Cancer : Incidence and Risk Factors
Post Mastectomy Pain Syndrome (PMPS) is a major complication of breast surgery responsible for depression and disability. The project consists of a prospective cohort on patients going for oncological breast surgery at National…
- Conditions
- Breast Neoplasms, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT04676438
- Where
- 2 sites in Morocco
- Volunteers
- 722 people
- Sponsor
- Moroccan Society of Surgery
Neuropathy;Peripheral
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
- Trial name
- NCT03037684
- Testing
- neurophysiology
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Uterine Bleeding, Uterine Neoplasms
Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies
The main goal of this randomised double-blinded controlled trial is to assess whether adding anterior quadratus lumborum block preoperatively can reduce intraoperative and postoperative opioid consumption, reduce pain after…
- Conditions
- Uterine Bleeding, Uterine Neoplasms, Uterine Diseases, Uterine Fibroids
- Trial name
- NCT07046949
- Testing
- ANTERİOR QUADRATUS LUMBORUM BLOCK, Parenteral administration of analgesics, General Anesthesia (GA)
- Where
- Ukraine
- Volunteers
- 56 people
- Sponsor
- Yuri Semenyuk Rivne Regional Clinical Hospital
Postoperative Chronic Pain
Postoperative Chronic Pain in Children Aged 8 to 17
The objective of this study is to assess the incidence of chronic postoperative pain in pediatric patients aged 8 to 17 years following surgical procedures.
- Trial name
- NCT07120399
- Where
- Turkey (Türkiye)
- Volunteers
- 323 people
- Sponsor
- Kocaeli University
Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS)
Erector Spinae Plane Block in Uniportal VATS
The main aim of this study is to compare the effectiveness of three alternative techniques (continuous Erectus Spinae Plane Block : c-ESPB; continuous Serratus Anterior Plane Block : c-SAPB; and Intercostal Nerve Block: ICNB) in…
- Conditions
- Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS), Lung Resections, Post-Operative Pain, Chronic
- Trial name
- ESPB-UVATS (NCT04892901)
- Testing
- c-ESPB, c-SAPB, ICNB
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Pain
Efficacy of Parasternal Blocks in Cardiovascular Surgery Patients Undergoing Median Sternotomy
Acute and chronic pain after cardiac surgery is a common problem that negatively affects quality of life. Postoperative pain after cardiac surgery is most intense in the first two days and decreases in the following period.
- Trial name
- NCT06387095
- Testing
- 1. no block, 2. superficial parasternal block, 3. deep parasternal block
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Postoperative Pain, Cerebral Palsy
Postoperative Pain in Children With Cerebral Palsy After Pelvic and Femoral Osteotomies
This study is a comparison of postoperative pain in children with cerebral palsy after surgery on the hip or femur. One group is treated with p.o.
- Trial name
- NCT00964639
- Testing
- Ropivacaine, Saline
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Chronic Post-surgical Pain
Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify…
- Trial name
- NCT05304286
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Chronic Pain, Opioid Use
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
The goal of this interventional clinical trial is to assess opioid consumption 24-48 hrs post anesthesia block among patients undergoing total knee arthroplasty. The main question it aims to answer is: 1.
- Conditions
- Chronic Pain, Opioid Use, Adductor Canal Block, Total Knee Arthroplasty
- Trial name
- NCT05981105
- Testing
- ambIT pump with catheter
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Hospital for Special Surgery, New York
LUMBAR STENOSIS
Pain After Microsurgical Decompression
This prospective observational cohort study aims to determine whether a combination of preoperative clinical, psychological, sleep-related, inflammatory, genetic, and epigenetic factors can predict chronic postoperative pain 12…
- Trial name
- NCT07883694
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University
Persistent Postsurgical Pain, Arthritis Knee
Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties
The study is a nationwide, register-based cohort survey study. The objective of this study is to investigate whether weight change is associated with the incidence of persistent postoperative pain following total hip arthroplasty…
- Conditions
- Persistent Postsurgical Pain, Arthritis Knee, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT06024161
- Testing
- Weight gain, Weight loss, Weight unchanged
- Volunteers
- 6,400 people
- Sponsor
- Bispebjerg Hospital
Neuroma, Cryoablation
Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation
atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life.
- Trial name
- AXON-FREEZE (NCT07618689)
- Testing
- Perineuroma Cryoablation, Proximal Nerve Cryoablation
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Internal Hernia, Mesocolic Hernia
Internal Hernias After Laparoscopic Gastric Bypass
The main goal of this study is to describe the trends in the incidence rate of internal hernia presentation after different modifications of the mesenteric closure technique after primary laparoscopic Roux-en-Y gastric bypass…
- Conditions
- Internal Hernia, Mesocolic Hernia, Petersen´s Hernia, Jejunojejunostomy Hernia
- Trial name
- IHafterLRYGB (NCT01040364)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of California, San Francisco