Clinical trials: Chronic Post-operative Pain
Chronic Pain, Complex Regional Pain Syndrome
Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients
It's well known that Spinal cord stimulation (SCS) changes the perception of chronic pain in the area stimulated by epidural electrodes.
- Conditions
- Chronic Pain, Complex Regional Pain Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT02837822
- Testing
- Spinal cord stimulator, Implantation of a spinal cord stimulator
- Where
- 2 sites in United States, Canada
- Volunteers
- 38 people
- Sponsor
- CHU de Quebec-Universite Laval
Chronic Postsurgical Pain, Acute Postoperative Pain
Persistent Pain and Its Impact on Daily Life After Lung Surgery
This study will examine how pain changes over the first six months after lung surgery and how it affects daily life. It will include adults scheduled for surgery to remove part or all of a lung.
- Conditions
- Chronic Postsurgical Pain, Acute Postoperative Pain, Pain-Related Functional Interference
- Trial name
- NCT07853456
- Testing
- Longitudinal Assessment of Pain and Pain-Related Functional Interference
- Volunteers
- 350 people
- Sponsor
- Aerospace Center Hospital
Post Operative Pain
Postoperative Pain After Using Different Single-File Glide Path Systems
This study aimed to evaluate postoperative pain intensity after glide-path preparation with the ProGlider (PG) and WaveOne Gold Glider (WOGG) systems in asymptomatic teeth with necrotic pulp and periapical lesions.Maxillary and…
- Trial name
- NCT05955742
- Testing
- Control, ProGlider, WaveOne Gold Glider
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Chronic Pain, Surgery
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain
The investigators will approach elective cardiac and thoracic surgery patients in the preoperative consultation clinic. Consenting individuals will be administered, before surgery validated pain, psychological and sleep…
- Trial name
- CT-Pain (NCT04798573)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Chronic Pain
Sensory Abnormalities in Post-surgical Peripheral Neuropathy
The concept of normality is a cornerstone in medical practice and research. As an example, in clinical chemistry, a laboratory value based on a plasma sample exceeding the +/- 1.96 x standard deviation (SD) range, referenced from…
- Trial name
- NCT03966677
- Where
- Denmark
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Pain, Postoperative
Chronic Pain Following Thoracic Surgery
Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem.
- Trial name
- PTPS-18 (NCT01144845)
- Testing
- Thoracic surgery
- Where
- Denmark
- Volunteers
- 702 people
- Sponsor
- University of Aarhus
Perioperative Pain Management
Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.
This study aimed To investigate the effects of different doses of Intraoperative intravenous lidocaine infusion on intraoperative opioid consumption, perioperative pain control and incidence of postoperative chronic pain.
- Trial name
- NCT06431165
- Testing
- Lidocaine IV
- Where
- Egypt
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Pain Syndrome, Thoracotomy
Retrospective Analysis of Factors Affecting Chronic Postoperative Pain After Thoracotomy
The aim of this retrospective study is to determine the factors affecting the development of chronic pain in patients with thoracotomy in the Thoracic Surgery Operating Rooms of İbn-i Sina Hospital.
- Trial name
- NCT05501977
- Testing
- thoracotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Ankara University
Chronic Postsurgical Pain
Effectiveness of Myofascial Release in Patients With Chronic Post Sternotomy Pain Syndrome
The main aim of this study is to investigate the effectiveness of Myofascial release in patients with chronic sternotomy pain.
- Trial name
- NCT06630208
- Testing
- Myofascial release, Breathing exercises, Pharmacological treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Osteo Arthritis Knee, Chronic Post-operative Pain
Pain Phenotyping in Knee OA: a Pilot Trial
Osteoarthritis (OA) is disease in which the joint breaks down, causing pain. The decision to surgically replace the knee, a procedure called total knee arthroplasty (TKA), depends on x-ray results as well as pain and dysfunction.
- Trial name
- NCT06066684
- Testing
- n/a, observational
- Where
- 2 sites in Canada
- Volunteers
- 55 people
- Sponsor
- University Health Network, Toronto
Postoperative Pain, Chronic Postsurgical Pain
Effect of Erector Spinae Plane Block on Neuropathic Pain After Abdominal Hysterectomy
This study evaluated whether bilateral erector spinae plane block (ESPB) performed before abdominal hysterectomy could reduce postoperative pain and the development of chronic and neuropathic pain.
- Trial name
- NCT07830706
- Testing
- Bupivacaine, Standard Perioperative Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Necmettin Erbakan University
Scoliosis Correction, Esketamine
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance.
- Conditions
- Scoliosis Correction, Esketamine, Dexmedetomidine, Postoperative Analgesia
- Trial name
- NCT06062550
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Chronic Pain, Knee Pain Chronic
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total…
- Conditions
- Chronic Pain, Knee Pain Chronic, Post Operative Pain
- Trial name
- PROVISION (NCT06123715)
- Testing
- Vitamin C
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Pain, Postoperative, Pain, Acute
Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks
The aim of this study will be to compare the effects of morphine versus ketamine when they are used as adjuvants to the local anesthetic in paravertebral nerve blocks performed with the aid of ultrasound.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- Annie-Dimitr (NCT04852484)
- Testing
- local anesthetic-morphine, local anesthetic-ketamine, local anesthetic
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Aretaieion University Hospital
Endometriosis, Postoperative Pain
Postoperative Pain Trajectories After Endometriosis Surgery
The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors.
- Conditions
- Endometriosis, Postoperative Pain, Pain Trajectories, Chronic Postsurgical Pain
- Trial name
- TRACK-ENDO (NCT07882498)
- Testing
- Perioperative quantitative sensory testing, questionnaire
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Surgery
Lidocaine and Prevention of Chronic Pain
The study seeks to investigate a safe and inexpensive strategy to reduce persistent post-surgical pain that can affect up to 60% of patients undergoing surgical procedures.
- Trial name
- NCT01619852
- Testing
- Group L (lidocaine)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Northwestern University
Analgesia, Acute Pain
Comparison of the Effects of QLB 2 and QLB 3 on Post-operative Analgesia in Cesarean Section Surgery
This study evaluates the post-operative analgesic effects of quadratus lomborum block 2 and 3 (QLB 2, 3) in patients having cesarean section with spinal anesthesia.
- Conditions
- Analgesia, Acute Pain, Chronic Pain
- Trial name
- NCT04364906
- Testing
- Regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ondokuz Mayıs University