Clinical trials: Chronic Postoperative Pain
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Chronic Pain, Pain Measurement
Relationship of Intra-Epidermal Nerve Fibre Density (IENFD) and Structure to Chronic Post-Mastectomy Pain Syndrome (PMPS)
This is a retrospective, observational study which will utilise the Edinburgh Cancer Research Centre's Tissue Bank to provide samples for IENFD testing in those who have undergone mastectomy surgery for breast cancer.
- Conditions
- Chronic Pain, Pain Measurement, Mastectomy, Postoperative Pain
- Trial name
- NCT02919891
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Royal Infirmary of Edinburgh
Neuropathy;Peripheral
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
- Trial name
- NCT03037684
- Testing
- neurophysiology
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Chronic Postoperative Pain, Chest Pain
The Effectiveness of Thoracal Epidural Steroid and Local Anesthetic Injection
The primary objective was to evaluate the effectiveness of thoracic interlaminar epidural injections in alleviating pain and enhancing function in patients suffering from chronic mid and/or upper back pain.
- Conditions
- Chronic Postoperative Pain, Chest Pain, Back Pain
- Trial name
- NCT06507995
- Testing
- thoracic interlaminar epidural injection
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara University
Post-operative Chronic Pain
Shifting Pain Modulation From Pro-to Anti-nociceptive
To create a data base that will facilitate the enrichment of the insights regarding post-operative pain development, and to identify those individuals with the potential to develop this kind of pain.
- Trial name
- NCT02672202
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Acute Postoperative Pain
Effects of tDCS and VNS on Postoperative Analgesia
This study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general…
- Trial name
- NCT06554067
- Testing
- Active transcranial direct current stimulation, Active vagus nerve stimulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Chronic Pain
Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome
The purpose of this study is to learn whether or not certain risk factors and patient characteristics are linked with and possibly can predict the development of chronic pain after lumbar spine surgery.
- Trial name
- NCT03444168
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Postoperative Acute Pain, Chronic Pain
Comparison of Postoperative Analgesic Efficacy of Interscalene and Suprascapular Blocks Used in Arthroscopic Shoulder Surgery
The Importance of Postoperative Analgesia in Shoulder Surgery Shoulder surgery is an orthopedic procedure that can be performed either through open surgery or arthroscopically.
- Trial name
- NCT07483814
- Testing
- rescue analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Pain, Postoperative, Intrathoracic Procedure
Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy
The researchers will compare the common methods of post-surgical pain control, such as epidural or intercostal nerve block with a newer method called cryoablation.
- Trial name
- NCT06384664
- Testing
- Atricure's crysoSPHERE probe, Standard of Care
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Apical Periodontitis
Effect of Cyperus Articulatus on Bacterial Reduction and Postoperative Pain
Successful endodontic treatment depends on effective elimination of microorganisms from the infected root canal system and prevention of reinfection.
- Trial name
- NCT07892690
- Testing
- Cyperus articulatus
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Hernia, Inguinal, Chronic Postoperative Pain
Surgical Outcomes Following Neurectomy Based Upon Response to Local Anesthetic Injection in Chronic Groin Pain
The management of chronic pain after inguinal hernia surgery presents unique challenges. Ilioinguinal nerve blocks are often used in the initial treatment of this disease.
- Trial name
- NCT05386693
- Testing
- Ilioinguinal nerve block
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Cervical Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of lidocaine and ketamine in the same syringe versus remifentanyl analgesia in cervical spine…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05717361
- Testing
- ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Hysterectomy, Chronic Pain
Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy
Phase 1 (started in July 2019): Central Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete…
- Conditions
- Hysterectomy, Chronic Pain, Central Sensitisation, Anxiety Depression
- Trial name
- EPOCH (NCT04014829)
- Testing
- Pain-Pressure Threshold, Mechanical Temporal Summation, Hospital Anxiety and Depression Scale
- Where
- Singapore
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Postoperative Pain, Chronic Pain
Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers
This is a A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of a kappa receptor agonist HSK21542 in Healthy Volunteers.
- Trial name
- NCT04110886
- Testing
- HSK21542
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Post Operative Pain
Postoperative Pain After Using Different Single-File Glide Path Systems
This study aimed to evaluate postoperative pain intensity after glide-path preparation with the ProGlider (PG) and WaveOne Gold Glider (WOGG) systems in asymptomatic teeth with necrotic pulp and periapical lesions.Maxillary and…
- Trial name
- NCT05955742
- Testing
- Control, ProGlider, WaveOne Gold Glider
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Chronic Pain
A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children
The purpose of this study is to investigate the prevalence, risk factors and consequences of chronic post-surgical pain in children aged 0-16 years through a number of questionnaires completed at various timepoints, from before…
- Trial name
- POPSICLE (NCT06354699)
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Telethon Kids Institute
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome
Paravertebral Versus Pectoralis Block for Post Mastectomy Pain
Post-mastectomy pain affects more than half of patients undergoing the procedure and can last for years. It has been well established that development of chronic pain is related to experienced pain in the perioperative period.
- Conditions
- Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome, Opioid Use
- Trial name
- NCT03656679
- Testing
- Pectoralis Blockade (PECs), Paravertebral Blockade
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Phantom Limb Pain
Electrical Stimulus Therapy for Chronic Phantom Limb Pain
The goal of this pilot study is to assess the effectiveness of an electrical stimulation therapy option for the treatment of chronic phantom limb pain in upper or lower limb amputees.
- Trial name
- NCT03030079
- Testing
- Experimental Electrical Stimulation Regimen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver