Clinical trials: Chronic Postoperative Pain
Esketamine, Pregabaline
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain.
- Conditions
- Esketamine, Pregabaline, Chronic Post Operative Pain
- Trial name
- NCT06117917
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Analgesia, Acute Pain
Comparison of the Effects of QLB 2 and QLB 3 on Post-operative Analgesia in Cesarean Section Surgery
This study evaluates the post-operative analgesic effects of quadratus lomborum block 2 and 3 (QLB 2, 3) in patients having cesarean section with spinal anesthesia.
- Conditions
- Analgesia, Acute Pain, Chronic Pain
- Trial name
- NCT04364906
- Testing
- Regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ondokuz Mayıs University
Pain, Chronic, Pain, Postoperative
Efficacy of Pain Neuroscience Education and Pre-anesthetic Assessment in Reducing Levels of Anxiety, Stress and Pain in Patients Undergoing Elective Total Abdominal Hysterectomy (ENAH Study)
Through this quantitative, multivariate factorial experimental parallel randomized clinical trial, the investigators analyzed the effectiveness of pre-anesthetic assessment and pain neuroscience education in reducing anxiety…
- Conditions
- Pain, Chronic, Pain, Postoperative, Anesthesia, Surgery
- Trial name
- NCT05435508
- Testing
- Pain Neuroscience Education, Usual care
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Neurociencia Del Dolor
Postoperative Pain, Video-Assisted Thoracoscopic Surgery
US-Guided ESPB Versus TPVB on Acute and Chronic Pain After VATS
Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary…
- Conditions
- Postoperative Pain, Video-Assisted Thoracoscopic Surgery, Thoracic Paravertebral Block, Erector Spinae Plane Block
- Trial name
- NCT04964401
- Testing
- Thoracic paravertebral block vs Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Impact of Repetitive Transcranial Magnetic Stimulation on the Prognosis of Elderly Surgical Patients
Exploring the effects of repeated transcranial magnetic stimulation (rTMS) during the perioperative period on the incidence of postoperative delirium, postoperative cognitive dysfunction, and chronic postoperative pain in elderly…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Chronic Post-surgical Pain
- Trial name
- NCT06392919
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Affiliated Hospital of Nantong University
Inguinal Hernia, Femoral Hernia
Factors Influencing the Results of Treatment in Patients With Hernias of Various Localizations
The study attempts to quantify the relative risks for acute postoperative pain, complications rate, chronic postoperative pain (CPIP) and recurrence rate after different methods of repair of groin, umbilical and incisional hernia…
- Conditions
- Inguinal Hernia, Femoral Hernia, Umbilical Hernia, Ventral Hernia
- Trial name
- NCT05920200
- Testing
- open non-mesh hernia repair, open mesh hernia repair, MIS hernia repair
- Where
- Russia
- Volunteers
- 4,000 people
- Sponsor
- Immanuel Kant Baltic Federal University
Serratus Plane Block, Chronic Pain
Serratus Plane Block in Preventing Postoperative Pain of Mastectomy
A prospective, double-blinded randomized controlled, 1-year follow-up study was designed to compare the analgesic effect of serratus plane block (SPB) after breast cancer surgery.
- Conditions
- Serratus Plane Block, Chronic Pain, Breast Cancer
- Trial name
- NCT03615430
- Testing
- serratus plane block with local anesthetic, serratus plane block with saline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Feng Xia
Arrythmia, Chronic Pain
Acute and Chronic Pain After One-stage Hybrid Arrhythmia Ablation Surgery
After one-stage hybrid arrhythmia ablation surgery there are possible side effects like acute and chronic pain. There is a lot of research surrounding these pains but not specifically after one-stage hybrid arrhythmia ablation…
- Conditions
- Arrythmia, Chronic Pain, Acute Pain, Post Operative Pain
- Trial name
- NCT05211492
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Postoperative Pain, Pediatric ALL
Chronic Postsurgical Pediatric Pain. Evaluation Risk Factors to Develop Chronic Postsurgical Pain in Children and Adolescents Undergoing Surgery in a First Level Hospital
Chronic postsurgical pain had number of prevalence on 20%. Its derivates from risk factors, but recent research provide new potential risk factors to develop chronic postsurgical pediatric pain.
- Trial name
- NCT04735211
- Testing
- Surgery
- Where
- Spain
- Volunteers
- 260 people
- Sponsor
- Guillermo Ceniza Bordallo
Pain, Postoperative, Anxiety Preoperative
The Efficacy of a Mindfulness-Based Virtual Reality Intervention to Reduce Pain in Postoperative Patients
The goal of this randomized clinical trial is to evaluate whether a virtual reality (VR) mindfulness intervention can reduce anxiety and postoperative pain in adults undergoing surgery, primarily hernia and varicose vein…
- Trial name
- VR-MindPain (NCT06961695)
- Testing
- VR Mindfulness-Based Relaxation
- Volunteers
- 64 people
- Sponsor
- Babes-Bolyai University
Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled, Persistent Post Surgical Pain
The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain.
- Trial name
- NCT03095157
- Testing
- fractionated marine lipid concentrate derived from anchovy and sardine oil
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Chronic Post-surgical Pain
Chronic Post Surgical Pain-Cardiac
The CPSP-Cardiac is a large, multi-center, observational study with the aim to investigate the incidence of chronic pain in the 3rd month postoperatively in cardiac surgery and its affecting factors.
- Trial name
- CPSP-Cardiac (NCT06382077)
- Where
- 29 sites in Turkey (Türkiye)
- Volunteers
- 2,442 people
- Sponsor
- Ondokuz Mayıs University
Postoperative Pain
NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain
The investigators investigated whether a strictly controlled pain management with patients participating in a clinical study can attenuate persistence of post-thoracotomy pain.
- Trial name
- NCT01541137
- Testing
- Diclofenac, parecoxib/ valdecoxib, patient controlled epidural analgesia
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Pain, Acute, Pain, Postoperative
The Impact of Esmolol Administration on Postoperative Recovery
The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain
- Conditions
- Pain, Acute, Pain, Postoperative, Pain, Chronic Post-Surgical, Esmolol
- Trial name
- esmolol (NCT05567822)
- Testing
- Esmolol Hydrochloride, normal saline
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aretaieion University Hospital
Knee Disease, Knee Deformity
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy.
- Conditions
- Knee Disease, Knee Deformity, Knee Pain Chronic, Knee Arthropathy
- Trial name
- NCT06084403
- Testing
- 20 ml volume adductor canal block, 30 ml volume adductor canal block, 40 ml volume adductor canal block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa City Hospital
Pain, Postoperative
Observational Study of an Automatic Detection of Patients at Risk of Chronic Postoperative Pain ("Alerte Douleur")
Following surgery, some but not all patients develop persistent (or chronic) postoperative pain CPSP. Several risk factors for this persistent pain have been confirmed in previous studies, but neither surgeons nor…
- Trial name
- ALDO (NCT03164954)
- Testing
- automatic risk detection
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Benno Rehberg-Klug
Postoperative Pain, Chronic Pain
Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers
This is a A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of a kappa receptor agonist HSK21542 in Healthy Volunteers.
- Trial name
- NCT04110886
- Testing
- HSK21542
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Chronic Pain, Cardiac Surgery
Bilateral Erector Spinae Plane Block for Postoperative Chronic Pain After Open Heart Surgery
The aim of this study is to investigate the effect of bilateral erector spinae plane (ESP) block application on postoperative chronic pain in patients undergoing on-pump open-heart surgery.
- Conditions
- Chronic Pain, Cardiac Surgery, Post Operative Pain
- Trial name
- NCT06315959
- Testing
- Bilateral ultrasound guided erector spinae plane block, morphine PCA, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Ondokuz Mayıs University
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071988
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Chronic Shoulder Pain
Exparel for Total Shoulder Pain
Total shoulder surgery (arthroplasty) is a widely successful method of treating shoulder arthritis. Although the goal of the procedure is pain relief, post-operative pain is unavoidable.
- Trial name
- ETSP (NCT03739021)
- Testing
- Exparel, Ropivacaine
- Volunteers
- 60 people
- Sponsor
- University of South Florida