Clinical trials: Chronic Pulmonary Obstruction
Chronic Obstructive Pulmonary Disease (COPD)
A Pragmatic Cluster Trial of a Tailored Intervention to Improve COPD Management
Background: Chronic Obstructive Pulmonary Disease (COPD) remains a major health problem, which is strongly related to smoking. Despite publication of guidelines on the prevention and treatment of COPD, not all COPD patients…
- Trial name
- TICD-COPD (NCT01893476)
- Testing
- Implementation educational programme
- Where
- Poland
- Volunteers
- 540 people
- Sponsor
- Medical University of Lodz
Chronic Obstructive Pulmonary Disease
A Study on the Microcirculatory Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With COPD
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches.
- Trial name
- NCT04045418
- Testing
- Laser doppler
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang Chinese Medical University
Asthma, Chronic Obstructive Pulmonary Disease
Usability and Acceptability Study of the P-STEP Mobile Application
Assess the usability and acceptance of the P-STEP app, through allowing participants with specific chronic conditions to pilot the app for 12-weeks.
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Coronary Heart Disease
- Trial name
- NCT05830318
- Testing
- P-STEP Mobile Application
- Where
- United Kingdom
- Volunteers
- 178 people
- Sponsor
- University of Leicester
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Safety and Effectiveness of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease
This study is being conducted to see if PRX-08066 can lower pulmonary artery pressures in patients with pulmonary hypertension associated with chronic obstructive pulmonary disease.
- Trial name
- NCT00345774
- Testing
- PRX-08066
- Where
- 19 sites in United States
- Volunteers
- 72 people
- Sponsor
- Epix Pharmaceuticals, Inc.
Chronic Obstructive Pulmonary Disease
Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations
People living with chronic obstructive pulmonary disease (COPD) may experience worsening of symptoms such as shortness of breath, cough and wheezing in addition to changes that may be expected for having COPD.
- Trial name
- OPACE (NCT05772013)
- Testing
- Azithromycin Pill
- Where
- United Kingdom
- Volunteers
- 1,311 people
- Sponsor
- Dr Ian B Wilkinson
COPD
Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation
In our study, changes in vastus lateralis muscle oxygenation will be evaluated with the Moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in COPD cases and the healthy…
- Trial name
- NCT06217276
- Testing
- Respiratory muscle fatigue protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Obstructive Pulmonary Disease
Analysis of Postural Control of COPD Patients (ATTRACTION)
Chronic Obstructive Pulmonary Disease (COPD) is a common chronic respiratory disease, causing disabling respiratory symptoms and impairing patients' quality of life.
- Trial name
- ATTRACTION (NCT05211674)
- Testing
- quantified analysis of postural control during activities of daily living
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Rennes 2
Pulmonary Disease, Chronic Obstructive
Effect on Exercise Endurance and Lung Hyperinflation of Tiotropium + Olodaterol in COPD Patients
The primary objective of this trial is to investigate the effect of 6 weeks treatment with tiotropium + olodaterol fixed dose combination inhalation solution on lung hyperinflation and exercise tolerance in patients with COPD
- Trial name
- NCT01533922
- Testing
- Tiotropium, Olodaterol, tiotropium + olodaterol
- Where
- 44 sites in United States, Argentina and 8 more
- Volunteers
- 295 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Continuous Positive Airway Pressure Versus Noninvasive Ventilation in Patients With Overlap Syndrome
The purpose of this study is to determine if Bipap should assume a standard-of-care role in the management of overlap syndrome.
- Conditions
- Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overlap Syndrome
- Trial name
- OS (NCT01427673)
- Testing
- Bipap procedure
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- United States Air Force
Myocardial Infarction, Chronic Obstructive Pulmonary Disease
Survival After First Myocardial Infarction in Patients With and Without Chronic Obstructive Pulmonary Disease
An estimated three million people are affected by chronic obstructive pulmonary disease (COPD) in the UK, giving it a prevalence of 1.5% of the population in 2007/08.
- Trial name
- NCT01335672
- Where
- United Kingdom
- Volunteers
- 2,100,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Chronic Obstructive Pulmonary Disease
Effects of Diaphragm and Abdominal Muscle Training on PFT and Dyspnea Among COPD Obstructive Pulmonary Disease Patients.
It will be a randomized control trial at Services Hospital Lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to Group A and Group B .
- Trial name
- NCT05587829
- Testing
- • Diaphragmatic breathing technique, basic breathing technique
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Obstructive Airway Disease
Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)
Patients with both sleep apnea and COPD have overlap syndrome, but their optimal management is not known. We plan to conduct a randomized trial of of bi-level PAP vs.
- Trial name
- NCT01261377
- Testing
- Bi-level positive airway pressure (BPAP), Oxygen, CPAP
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Chronic Obstructive Pulmonary Disease
Exacerbations and Health Related Quality of Life in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) exacerbation is a major cause of physician visits and hospital admissions associated with acute respiratory failure, causing increased morbidity and premature mortality and thus it can…
- Trial name
- NCT00884975
- Volunteers
- 102 people
- Sponsor
- University of Thessaly
Healthy
The Bioavailability of a Spray Dried Dispersion Solid Dose Formulation of PF-06260414 Relative to a Suspension Formulation
The current study will investigate the relative bioavailability of a spray dried dispersion solid dose formulation of PF 06260414 administered as a single oral dose of 30 mg of PF 06260414 relative to a single oral dose of 30 mg…
- Trial name
- NCT02393807
- Testing
- PF 06260414 solid dose formulation, PF-06260414 nanosuspension
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
COPD (Chronic Obstructive Pulmonary Disease)
Effects of Alternate Nostril Breathing and Bellows Breath in COPD Patients
COPD is a common respiratory disease characterized by progressive airflow obstruction, dyspnea, chronic cough, and sputum production.
- Trial name
- NCT07719192
- Testing
- alternate nostril breathing, bellows breath
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Chronic Obstructive Pulmonary Disease
Relationship Between Metabolic Profile and Clinical Phenotype in Chronic Obstructive Pulmonary Disease
Despite the high prevalence of chronic obstructive pulmonary disease (COPD), there continues to be a large gap in our understanding of disease pathogenesis and mechanisms accounting for large variability in disease phenotype.
- Trial name
- NCT03310177
- Where
- China
- Volunteers
- 167 people
- Sponsor
- Peking University Third Hospital
Pulmonary Disease, Chronic Obstructive
Long-term Safety Study for GSK573719/GW642444 in Japanese
The objective of this study is to evaluate the safety and tolerability of GSK573719/GW642444 Inhalation Powder 125/25 mcg once-daily.
- Trial name
- DB2115362 (NCT01376388)
- Testing
- GSK573719/GW642444 Inhalation Powder
- Where
- 23 sites in Japan
- Volunteers
- 131 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Cor Pulmonale
Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale
Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale potentially due to venous obstruction in the portal vein system.
- Trial name
- NCT03243994
- Testing
- Absorption test with D-xylose and zink
- Volunteers
- 14 people
- Sponsor
- Jens Rikardt Andersen
Bronchiectasis, Chronic Obstructive Pulmonary Disease
The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations.
- Trial name
- NCT03950531
- Testing
- No intervention
- Volunteers
- 122 people
- Sponsor
- Ministry of Health, Turkey
COPD, Chronic Obstructive Pulmonary Disease
Study of COPD Subgroups and Biomarkers
SPIROMICS I, SPIROMICS II, and SPIROMICS III are longitudinal observational studies of Chronic Obstructive Pulmonary Disease (COPD) cohort.
- Conditions
- COPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
- Trial name
- SPIROMICS (NCT01969344)
- Where
- 14 sites in United States
- Volunteers
- 2,981 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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