Clinical trials: Chronic Pulmonary Obstruction
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD
Laying the Foundation for Building a Resilient KPNC Community in the Face of Worsening Air Quality Due to Wildfire Smoke
The overarching goal of this project is to conduct a pilot intervention in high-risk Kaiser Permanente Northern California patients with chronic obstructive pulmonary disease to mitigate their exposure to poor air quality and…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation of COPD, Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- DS-F (NCT07118189)
- Testing
- N95 masks and indoor air cleaner
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Chronic Obstructive Pulmonary Disease (COPD)
A Prospective, Cohort Study of Hyperpolarized 3He MRI in Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine the MRI characteristics of Chronic Obstructive Pulmonary Disease subjects both at baseline and yearly for a period of 5 years, and to correlate these biomarkers with pulmonary function…
- Trial name
- NCT02734368
- Testing
- Hyperpolarized Helium-3
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation
Trial to Study Intubation Rates of Non-invasive Ventilation Using Pressure Support Ventilation (PSV) Versus Adaptive Support Ventilation (ASV) Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The clinical course of chronic obstructive pulmonary disease (COPD) is associated with recurrent episodes of exacerbation that results in respiratory failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation, Adaptive Support Ventilation
- Trial name
- PSV vs ASV for (NCT02877524)
- Testing
- Adaptive support ventilation, Pressure support ventilation
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COPD, Emphysema
Evaluation of Immunological, Microbiological and Metabolomic Profiles in COPD
COPD is a significant health problem worldwide. It affects more than 10% of patients over the age of 40. According to the World Health Organization, it is the third most common cause of death among adults in the world, and the…
- Conditions
- COPD, Emphysema, Chronic Bronchitis, Smoking
- Trial name
- NCT06826560
- Where
- Poland
- Volunteers
- 92 people
- Sponsor
- Medical University of Warsaw
Pulmonary Disease, Chronic Obstructive (COPD)
Real-world, 52-week Prospective Study to Capture the Reasons for Switch to Triple Combination Therapy, Assess the Clinical and Patient Reported Outcomes in Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece
Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive respiratory condition characterized by irreversible airflow limitation.
- Trial name
- TRIAENA (NCT05915182)
- Testing
- Budesonide Glycopyrronium bromide Formoterol fumarate pressurized Metered Dose Inhaler
- Where
- 15 sites in Greece
- Volunteers
- 212 people
- Sponsor
- AstraZeneca
COPD (Chronic Obstructive Pulmonary Disease)
Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators
The purpose of this study is to compare the effectiveness of inhaled bronchodilators delivered via nebulizers vs. dry powder inhalers (DPIs) in symptomatic participants with Chronic Obstructive Pulmonary Disease (COPD) who have…
- Trial name
- NCT07133880
- Testing
- umeclidinium 62.5 µg and vilanterol 25 µg, Revefenacin 175 µg, Formoterol 20 µg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Tennessee Graduate School of Medicine
COPD, Lung Cancer
Prevalence of COPD in Our Lung Cancer Population, Compared to Controls
This study will investigate the prevalence of chronic obstructive pulmonary disease (COPD) in patients who are newly diagnosed with lung cancer and compare it to the prevalence of COPD in controls recruited from a smoking…
- Conditions
- COPD, Lung Cancer, Smoking
- Trial name
- NCT02603627
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Russian Current and Expiratory Muscle Training in COPD Patients
Respiratory muscles are essential to alveolar ventilation. In COPD, these muscles work against increased mechanical loads due to airflow limitation and geometrical changes of the thorax derived from pulmonary hyperinflation.
- Trial name
- NCT04704479
- Testing
- Russian current, EMT
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Obstructive Airway Disease
Pulmonary Disease in a Psychiatric Inpatient Population
Purpose: Patients with mental health disorders have a reduced life expectancy, compared to the general population. The shorter life expectancy is caused by natural and unnatural death.
- Trial name
- NCT01823627
- Testing
- Spirometry with reversibility test
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Psykiatrien Syd
Postoperative Pain, Satisfaction with Care
Thoracic Spinal Versus Thoracic Epidural Anesthesia for Patients with Chronic Obstructive Pulmonary Disease Undergoing Supine Percutaneous Nephrolithotomy for Management of Renal Stones.
Owing to the elevated risk of perioperative comorbidities, chronic obstructive and restrictive pulmonary disorders can be a challenging task for the anesthetist.
- Trial name
- NCT06663488
- Testing
- Thoracic epidural anesthesia, Thoracic spinal anesthesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Chronic Obstructive Pulmonary Disease
Analysis With Clusters of QUAntitative Tomodensitometric Vascular, bronchIal and Parenchymal Pulmonary Parameters for COPD Patients
Chronic obstructive pulmonary disease (COPD) is caused by tobacco consumption. The goal is to characterize on clinical and radiological data, using computed tomography, this illness in order to improve diagnostic and be able to…
- Trial name
- ACQUAVIP (NCT03337854)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Bordeaux
Chronic Obstructive Pulmonary Disease
Using Clinical Prediction Models to Improve Treatment for Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease of the lungs that affects more than 2.5 million Canadians. Patients with COPD experience episodes of lung attacks (or exacerbations).
- Trial name
- NCT05309356
- Testing
- ACCEPT Decision Intervention, Comparator
- Where
- 2 sites in Canada
- Volunteers
- 1,130 people
- Sponsor
- University of British Columbia
COPD (Chronic Obstructive Pulmonary Disease)
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative
The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted will still derive symptomatic benefit from…
- Trial name
- RETHINC (NCT02867761)
- Testing
- Indacaterol/Glycopyrrolate
- Where
- 16 sites in United States
- Volunteers
- 780 people
- Sponsor
- University of Michigan
Hypertension, Diabetes Mellitus, Type 2
Enhancing Community Health Through Patient Navigation, Advocacy and Social Support
Some patients who have multiple long-term health conditions have significant challenges accessing needed services despite available primary care and social services resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT03077386)
- Testing
- ENCOMPASS Intervention
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University of Calgary
Pulmonary Disease, Chronic Obstructive
Effects of Once Daily Tiotropium in Patients With Chronic Obstructive Pulmonary Disease (COPD) of Different Severity
The primary objective of this study is to investigate the effect of tiotropium vs. placebo on trough FEV1 and FEV1 2 hours post inhalation after 12 weeks of treatment. For both endpoints changes from baseline will be analysed.
- Trial name
- NCT00274573
- Testing
- Tiotropium bromide
- Where
- 177 sites in Germany
- Volunteers
- 1,639 people
- Sponsor
- Boehringer Ingelheim
Smoking, Airway Obstruction
Effect of the Salbutamol on Mechanical Properties of Respiratory System
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
- Trial name
- NCT01521572
- Testing
- Salbutamol sulphate
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Chronic Obstructive Pulmonary Disease
Short Compared With Standard Duration of Antibiotic Treatment for AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease.
- Trial name
- AECOPD (NCT03698682)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease, Emphysema
Lung Volume Reduction Coil Microbiome Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema
- Trial name
- LVRC-Micro (NCT03010566)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COPD
Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD
Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by long-term poor airflow, resulting in chronic pulmonary heart disease, chronic respiratory failure or even death.
- Trial name
- NCT03655795
- Testing
- Bronchial basal cells
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Chronic Obstructive Pulmonary Disease
Evaluation of Efficacy and Safety of Formoterol in Patients With COPD Compared With Placebo in Patients in Japan, EU
The purpose of this study is to show the efficacy and safety of formoterol for the maintenance treatment of patients with COPD compared with placebo in patients in Japan and in European countries during 12 weeks.
- Trial name
- OCEAN (NCT00628862)
- Testing
- Formoterol Turbuhaler® 4.5mg, Formoterol Turbuhaler® 9 mg
- Where
- 47 sites in Bulgaria, Japan and 3 more
- Volunteers
- 613 people
- Sponsor
- AstraZeneca
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