Clinical trials: Chronic Pulmonary Obstruction
Pulmonary Disease, Chronic Obstructive
A Study of MK0359 in Patients With Chronic Obstructive Pulmonary Disease (COPD)(0359-016)
A study to test the effect of MK0359 in lessening the symptoms of COPD as compared to salmeterol and placebo.
- Trial name
- NCT00482235
- Testing
- MK0359
- Volunteers
- 45 people
- Sponsor
- Merck Sharp & Dohme LLC
COPD (Chronic Obstructive Pulmonary Disease), Cardiovascular Disease
Impact of Combined Cardio-pulmonary Assessment on COPD Clinical Management.
The goal of this randomized clinical trial is to learn whether a combined cardio-pulmonary assessment improves cardiac function, exercise capacity, cardiac biomarkers and health-related quality of life in adults with…
- Trial name
- ICARUS (NCT07481825)
- Testing
- Structured combined cardio-pulmonary clinical management strategy, Standard Respiratory Management
- Volunteers
- 350 people
- Sponsor
- University of Bari Aldo Moro
Chronic Obstructive Pulmonary Disease
Efficacy, Safety, and Tolerability of Once Daily Indacaterol in Chronic Obstructive Pulmonary Disease (COPD) Using Formoterol Twice Daily as Active Control
This study was designed to assess the efficacy and long-term safety of 300 and 600 µg doses of indacaterol when delivered via a single-dose dry-powder inhaler (SDDPI) in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00393458
- Testing
- Indacaterol, Formoterol
- Where
- 183 sites in Argentina, Chile and 23 more
- Volunteers
- 1,732 people
- Sponsor
- Novartis
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Influenza, Human
Effectiveness of Xuanfei Jiangzhuo Decoction for Influenza-Induced AECOPD
The goal of this observational study is to learn if a traditional Chinese herbal medicine (Xuanfei Jiangzhuo Decoction) works to help older adults recover from a COPD flare-up caused by the flu (influenza virus).
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Influenza, Human, Virus Diseases
- Trial name
- NCT07393685
- Testing
- Xuanfei Jiangzhuo Decoction, Standard Antiviral Therapy (Oseltamivir or Baloxavir marboxil)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tianjin Medical University
COPD, COPD Exacerbation
A Retrospective rEal-life daTa Study to Assess the exaceRbations and Lung functIon in Chronic Obstructive Pulmonary Disease ( COPD ) patiEnts receiVing Fluticasone/Salmeterol Comparing to Those Εscalating in Open-triple Fluticasone/Salmeterol, Long Acting Muscarinic Antagonist (LAMA) Combination
Inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA) combination is commonly prescribed to treat COPD; we will perform a retrospective analysis on the effect of adding a long-acting muscarinic receptor antagonist (LAMA) to…
- Trial name
- RETRIEVE (NCT03858348)
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Chronic Obstructive Pulmonary Disease
The Differences of Muscle Activity Between Patients With COPD and Healthy Adults
The purpose of this study attempts to investigate the differences and relationships of respiratory parameters, muscle activity, and dyspnea during ADL between patients with COPD and age-matched healthy participants.
- Trial name
- NCT04146948
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Pulmonary Disease, Chronic Obstructive
Pharmacokinetics, Safety and Tolerability of Twice-Daily Aclidinium Bromide/Formoterol Fumarate Fixed Dose Combination in Chinese Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
A Phase IIa, open-label, repeat-dose trial to investigate the pharmacokinetics (PK), safety and tolerability of single and multiple twice daily doses of inhaled Aclidinium Bromide/Formoterol Fumarate 400/12 μg in 20 Chinese male…
- Trial name
- NCT03276078
- Testing
- Aclidinium Bromide/Formoterol Fumarate 400/12μg BID
- Where
- China
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
High Dose Trial in COPD
The primary objective of this study was to compare the efficacy and safety of 200 μg and 400 μg of BEA 2180 BR to tiotropium 5 μg and placebo when each was delivered by the Respimat® Inhaler once daily for four weeks in patients…
- Trial name
- NCT00128440
- Testing
- BEA 2180 BR, tiotropium
- Where
- 13 sites in United States
- Volunteers
- 78 people
- Sponsor
- Boehringer Ingelheim
Pulmonary Emphysema
Collateral Ventilation Effects on Response to AeriSeal System Treatment in Upper Lobe Predominant Emphysema
This study will evaluate the effects of baseline collateral ventilation status on outcomes following treatment with AeriSeal System in patients with advanced upper-lobe predominant heterogenous emphysema.
- Trial name
- CV+/- (NCT01520740)
- Testing
- Emphysematous Lung Sealant
- Where
- 13 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Aeris Therapeutics
Pulmonary Disease, Chronic Obstructive
Effects of Liraglutide in Chronic Obstructive Pulmonary Disease
The study is a 44 weeks, prospective, randomized, placebo-controlled, double-blinded, parallel group two-center trial. Forty patients are recruited among the outpatients of the chronic obstructive pulmonary disease (COPD) clinic…
- Trial name
- NCT03466021
- Testing
- Liraglutide
- Where
- 2 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Claus Bogh Juhl
COPD
A Study to Evaluate Safety and Efficacy of BOTOX in Adults With Moderate COPD
The aim of this clinical trial to determine the safety and effectiveness of treating the COPD symptoms with subcutaneous BOTOX injections in participants with moderate COPD.
- Trial name
- NCT06003049
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- RMW Testing
Chronic Obstructive Pulmonary Disease
Effects of NIMV on the Health Status of Chronic Obstructive Pulmonary Disease (COPD )Patients
In this proposal, we will implement a randomized controlled trial to determine whether nocturnal NIMV applied for 3 months: 1) improves (disease-specific) health related quality of life (HRQL) of COPD patients compared to a…
- Trial name
- NCT00114426
- Testing
- non-invasive mechanical ventilation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Chronic Obstructive Pulmonary Disease (COPD)
Magnetic Stimulation of Diaphragm in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by persistent airflow limitation and respiratory symptoms due to airway and/or alveolar deterioration caused by severe exposure to…
- Trial name
- COPD (NCT06714721)
- Testing
- Repetitive peripheral magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara University
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer
- Trial name
- LoF (NCT07536178)
- Testing
- Woodsmoke (Lodgepole Pine) exposure, Filtered air exposure
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pulmonary Disease, Chronic Obstructive
Multiple Dose Comparison of Tiotropium Inhalation Capsules, Salmeterol Inhalation Aerosol and Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD)
To compare the long -term (six month) bronchodilator efficacy and safety of tiotropium inhalation capsules, salmeterol inhalation aerosol and placebo in patients with COPD.
- Trial name
- COPD (NCT02172287)
- Testing
- Tiotropium (Ba679 BR), Salmeterol
- Volunteers
- 623 people
- Sponsor
- Boehringer Ingelheim
Invasive Pulmonary Aspergillosis, Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease
The investigators propose to study the efficacy and safety of three-week antifungal therapy with caspofungin in hospitalized patients with proven or probable IPA underlying chronic obstructive pulmonary disease.
- Trial name
- NCT01499433
- Testing
- caspofungin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD, Smoking Cessation
Transtheoretical Model Based Nursing Interventions on Smoking Cessation in Patients With COPD
Background: The aim of this study is to evaluate the efficiency of nursing intervention based on smoking cessation transtheoretical model in patients with COPD who smoke Method: Experimental design was used in the study.
- Conditions
- COPD, Smoking Cessation, Home Visit
- Trial name
- NCT04313738
- Testing
- Assigned Interventions
- Volunteers
- 80 people
- Sponsor
- Dokuz Eylul University
Chronic Obstructive Pulmonary Disease
Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
The aims of this study is : to assess the bronchodilator (DUOVENT HFA) response of parameters measured by the forced oscillations (FOT) and in particular the reactance parameters related to the presence of a limitation of…
- Trial name
- NCT03910985
- Testing
- Duovent HFA
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire UCLouvain Namur
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
The Improvement of Indoor Air and Health Effects After Air Purifier Intervention Among Susceptible Population in Industrial Area
Invesitigators conducted a double-blind, randomized, and crossover study to investigate the effects of PCO and PCO + filters interventions on indoor air pollutants in households and health outcomes in susceptible group, such as…
- Trial name
- NCT07069907
- Testing
- Air purfiers with photocatalytic oxidation (PCO), Air purfiers with photocatalytic oxidation (PCO) + filters
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
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