Clinical trials: Chronic Respiratory Diseases
End-stage Renal Disease, SARS-CoV-2 Acute Respiratory Disease
SARS-COV-2 Screening in Dialysis Facilities
Patients receiving dialysis are one of the highest risk groups for serious illness with SARS-CoV-2 infection. In addition to the inherent risks of travel to and dialysis within indoor facilities, patients receiving dialysis are…
- Conditions
- End-stage Renal Disease, SARS-CoV-2 Acute Respiratory Disease, Dialysis; Complications
- Trial name
- NCT05225298
- Testing
- Offering SARS-CoV-2 test
- Where
- United States
- Volunteers
- 2,389 people
- Sponsor
- Stanford University
Major Depressive Disorder
Combining Medications to Enhance Depression Outcomes
This study will compare whether a combination of antidepressant medications is better than one antidepressant medication alone when given as initial treatment for people with chronic or recurrent major depressive disorder.
- Trial name
- CO-MED (NCT00590863)
- Testing
- Escitalopram + Bupropion SR, Venlafaxine XR + Mirtazapine
- Where
- 15 sites in United States
- Volunteers
- 665 people
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Thromboembolic Pulmonary Hypertension
Early Non-invasive Detection of CTEPH After Pulmonary Embolism
This is a prospective, international, multicenter outcome cohort study. This study starts at the moment patients visit the outpatient clinic 3 to 6 months after a diagnosis of acute PE as part of routine medical care.
- Trial name
- InShape2 (NCT02555137)
- Testing
- 'prediction score' and 'rule-out criteria'
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 424 people
- Sponsor
- Leiden University
COPD
Drug-drug Interaction Study of CHF5993 With Cimetidine
The purpose of this study is to evaluate the pharmacokinetic interaction when CHF5993 (pressurized metered-dose inhaler (pMDI) is administered with Cimetidine (probe inhibitor of the organic cation transport in the kidneys), by…
- Trial name
- NCT02287272
- Testing
- CHF 5993 pMDI, Cimetidine plus CHF5993 pMDI
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Lung Cancer, Precancerous Condition
Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol
RATIONALE: Studying the genes expressed in samples of blood and lung fluid in the laboratory from patients receiving budesonide and formoterol may help doctors learn more about the effect of budesonide and formoterol on gene…
- Trial name
- NCT00569712
- Testing
- budesonide/formoterol fumarate dihydrate inhalation aerosol, DNA methylation analysis, comparative genomic hybridization
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- British Columbia Cancer Agency
COPD
Effects of Long Term Macrolide Antibiotic Therapy in Patients With COPD
The purpose of this study is to determine whether long term treatment with oral erythromycin is effective in the treatment of subjects with Chronic Obstructive Pulmonary Disease (COPD) by reducing the number of exacerbations and…
- Trial name
- NCT00147667
- Testing
- Erythromycin
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Royal Free and University College Medical School
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Roflumilast on Lung Function in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Salmeterol: The EOS Study (BY217/M2-127)
The aim of the study is to compare the efficacy of roflumilast on pulmonary function and symptomatic parameters in patients with chronic obstructive pulmonary disease (COPD) during concomitant administration of salmeterol.
- Trial name
- EOS (NCT00313209)
- Testing
- Roflumilast
- Where
- 134 sites in Austria, Belgium and 8 more
- Volunteers
- 933 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Postmarketing Surveillance Study of Atrovent® Inhalets in Chronic Obstructive Airways Disease
To obtain further information on the tolerability of Atrovent® inhalets in the treatment of Chronic Obstructive Airways Disease under conditions of daily practice
- Trial name
- NCT02238132
- Testing
- ATROVENT® inhalets
- Volunteers
- 374 people
- Sponsor
- Boehringer Ingelheim
Asthma
Study to Assess the Efficacy of a Single PBF-680 Oral Administration to Attenuate Adenosine 5'-Monophosphate Challenge-induced Airway Hyperresponsiveness in Mild-to-moderate Asthmatics
This is a single-center, double-blind, randomized trial utilizing a three-period, balanced block design, with each period comprising a unique study product administration.
- Trial name
- NCT01939587
- Testing
- PBF-680 5 mg, PBF-680 20 mg
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sleep Apnea, Obstructive, Hypertension
Epidemiology and Intervention of Obstructive Sleep Apnea Based on Community
This observational study in a real-world community was designed to perform epidemiological investigation and assess effect of CPAP intervention of obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypertension, Obesity, Diabetes
- Trial name
- NCT03280914
- Testing
- Auto-CPAP
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Oxygen Supplementation on Cerebral Oxygenation, Symptoms and Performance During STST in COPD Patients
It is a randomised, single-blind trial of the effect of acute oxygen supplementation on cerebral oxygenation during the 30 sec Sit-To-Stand Test (STST) in chronic obstructive pulmonary disease patients, without resting hypoxemia.
- Trial name
- NCT07024914
- Testing
- Oxygen, medical air
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- George Papanicolaou Hospital
Post-Acute COVID-19 Syndrome
Exercise Training Using an App on Physical Cardiovascular Function Individuals With Post-covid-19 Syndrome
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome.
- Trial name
- Recovery (NCT06168006)
- Testing
- Exercise, Control
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Pulmonary Disease, Chronic Obstructive
Assessment of Comorbidities in Chronic Obstructive Pulmonary Disease (COPD) in European Symptomatic Subjects From Primary Care
This is a prospective, observational, non-drug interventional, non-randomized study to compare the rate of moderate-severe COPD exacerbations in patients of all Chronic Obstructive Pulmonary Disease (COPD) severities with and…
- Trial name
- ACCESS (NCT01516528)
- Testing
- Spirometry
- Where
- 233 sites in Belgium, France and 4 more
- Volunteers
- 3,500 people
- Sponsor
- GlaxoSmithKline
Study is Being Conducted in Healthy Volunteers
A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers
This study will be conducted to establish the relative bioavailability of budesonide and formoterol delivered via Symbicort pressurized metered-dose inhaler (pMDI) with and without a spacer device.
- Trial name
- NCT02934607
- Testing
- Symbicort pMDI with spacer device, Symbicort pMDI without spacer device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.
- Trial name
- EXHALBIO (NCT05437198)
- Testing
- collection of human exhalation
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
COPD Exacerbation, Trauma
FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS
Evaluation of automated oxygen titration in comparison with manual adjustment oxygen in the out-of-hospital setting by paramedics.
- Trial name
- NCT03696563
- Testing
- Automated oxygen administration - FreeO2, Standard administration of oxygen flow
- Volunteers
- 100 people
- Sponsor
- François Lellouche
Chronic Obstructive Pulmonary Disease
Replacement of Nebulised Ipratropium With Inhaled Tiotropium in Stable Chronic Obstructive Pulmonary Disease (COPD)
Some patients with chronic obstructive pulmonary disease (COPD) take nebulised treatments to ease the symptom of breathlessness, including the drug ipratropium.
- Trial name
- NCT00335621
- Testing
- Inhaled Tiotropium
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- NHS Greater Glasgow and Clyde
COPD Exacerbation Acute
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement.
- Trial name
- NCT06274957
- Testing
- CONTROL, PEP DEVICE, HFCWO DEVICE
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Saglik Bilimleri Universitesi
Shortness of Breath
Effect of Senobi Versus Buteyko Technique on Functional Performance of Chronic Obstructive Pulmonary Disease Patient.
Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient.
- Trial name
- NCT06196957
- Testing
- pursed lip breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Lung Cancer, Vagus Nerve Injuries
Vagus Nerve Preservation and Chronic Cough in Non-small Cell Lung Cancer Surgery
Lung cancer is the leading cause of cancer death worldwide. Surgical resection is the main treatment for resectable non-small-cell lung cancer (NSCLC), and lobectomy with systemic mediastinal lymph node dissection is the standard…
- Conditions
- Lung Cancer, Vagus Nerve Injuries, Cough
- Trial name
- NCT04923412
- Testing
- Pulmonary branch of vagus nerve preserved, Pulmonary branch of vagus nerve not preserved
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Seoul National University Bundang Hospital