Clinical trials: Chronic Respiratory Diseases
Lung Diseases, Pulmonary Disease, Chronic Obstructive
An Investigational Drug Study In Patients With COPD (Chronic Obstructive Pulmonary Disease) (MK-0873-005)
This is a study to evaluate the effectiveness and tolerability of a once-daily oral medication (MK-0873) for the treatment of COPD (chronic obstructive pulmonary disease) to determine whether the study drug leads to an…
- Trial name
- NCT00132730
- Testing
- MK-0873 2.5 mg, MK-0873 1.25 mg, MK-0873 0.75 mg
- Volunteers
- 604 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease
Comparison of Efficacy of Indacaterol Versus Placebo Over 12 Weeks
This 12-week study evaluated the efficacy and safety of indacaterol versus placebo.
- Trial name
- NCT01068600
- Testing
- Indacaterol
- Where
- 54 sites in United States
- Volunteers
- 318 people
- Sponsor
- Novartis
Pulmonary Disease, Chronic Obstructive
COPD MSA 3 Regions: Epidemiology and Risk Factors of COPD in Rural Environment (BM3R)
The agricultural environment presents a unique profile in terms of epidemiology of pulmonary diseases. Certainly due to persistent exposure to organic particles, the prevalence of COPD is higher in farmers than in the general…
- Trial name
- BM3R (NCT03299907)
- Testing
- Spirometry
- Volunteers
- 5,263 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Chronic Obstructive Pulmonary Disease
Do Educational Digital Films Enhance Patient COPD Outcomes?
This study aims to assess the efficacy of Pocket Medic to promote self-management and pulmonary rehabilitation adherence in COPD patients.
- Trial name
- NCT03263754
- Testing
- Pocket Medic, Pulmonary Rehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Aberystwyth University
Chronic Obstructive Pulmonary Disease
Tiotropium In Early Chronic Obstructive Pulmonary Disease Patients in China
Chronic obstructive pulmonary disease (COPD) is one of the commonest respiratory diseases. During the early stage of COPD, patients only have mild respiratory symptoms or signs which may lead to under-diagnosis of the disease.
- Trial name
- Tie-COPD (NCT01455129)
- Testing
- Tiotropium
- Where
- 25 sites in China
- Volunteers
- 841 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Depression, ESRD
Morbidity and Mortality Among Dialysis Patients After Treatment for Depression
Morbidity and Mortality among Dialysis Patients after Treating Depression Objectives Our investigation has two objectives: 1. To assess whether treatment and recovery from depression decreases adverse clinical events in chronic…
- Trial name
- NCT00442429
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Portland VA Medical Center
Pulmonary Disease, Chronic Obstructive
Repeat Doses Of A New Medication (GW642444) In Asthmatic Patients
In order to obtain information on a wider range of doses of GW642444 (a possible new medication to treat asthma) than has been previously examined in asthmatic patients, this current study will be conducted at doses of 25 100 and…
- Trial name
- NCT00347139
- Testing
- GW642444 (25, 100 & 400 mcg/day), Salmeterol 50mcg
- Where
- 7 sites in Germany, New Zealand and 3 more
- Volunteers
- 55 people
- Sponsor
- GlaxoSmithKline
COPD Exacerbation, COPD
Borg Score Outcomes in Respiratory Compromised Acute Exacerbating Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Treatment Via Vibrating Mesh Nebuliser Versus Jet Nebuliser in the Emergency Department
The purpose of this study is to compare clinical outcomes in patients with acute COPD treated with a vibrating mesh nebuliser (VMN) versus a current standard jet nebuliser (JN), in the Emergency Department (ED).
- Trial name
- BRAVE (NCT04181073)
- Testing
- Jet Nebuliser, Vibrating Mesh Nebuliser
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- NHS Greater Clyde and Glasgow
Chronic Obstructive Lung Disease, Respiratory Ilness
InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without…
- Conditions
- Chronic Obstructive Lung Disease, Respiratory Ilness, Estrogen Deficiency, Asthma
- Trial name
- ESSENTIAL (NCT06713512)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hypercapnic Respiratory Failure, COPD
Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
Hypothesis Treatment with HFNC and OptiflowTM+Duet can significantly reduce PaCO2 and normalize pH in patients with COPD exacerbation and acute hypercapnic failure, compared to HFNC with OptiflowTM.
- Trial name
- DUACT (NCT06257667)
- Testing
- Respiratory Support
- Volunteers
- 138 people
- Sponsor
- Aalborg University Hospital
Cardio-vascular Disease, Depression Disorders
Supporting Patients Starting New Medicines: Evaluating the myCare Start Service in Switzerland
In Phase B, the aim is to evaluate the myCare Start service in routine care within the ambulatory primary care medicine and community pharmacy setting in Switzerland.
- Conditions
- Cardio-vascular Disease, Depression Disorders, Diabetes, COPD
- Trial name
- myCare Start-I (NCT07036471)
- Testing
- myCare Start
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- University of Geneva, Switzerland
Seriously Ill Patients, Cancer
Goals of Care Conversations Study
The long term goal is to improve quality of care in Veterans with serious illnesses by aligning medical care with Veterans' goals and values.
- Conditions
- Seriously Ill Patients, Cancer, Heart Failure, Interstitial Lung Disease
- Trial name
- LSTDI (NCT05001009)
- Testing
- Clinician Implementation Strategy Stage 1: low intensity clinician training, Clinician Implementation Strategy Stage 2: high intensity clinician training, Low patient engagement
- Where
- 3 sites in United States
- Volunteers
- 2,859 people
- Sponsor
- VA Office of Research and Development
Pulmonary Disease, Chronic Obstructive, Rehabilitation
Remote Prescribed and Monitored Exercise Program After Pulmonary Rehabilitation in Individuals With Chronic Lung Disease
Remote Prescribed and Monitored Exercise Program After Pulmonary Rehabilitation in Individuals with Chronic Lung Disease
- Trial name
- NCT04599387
- Testing
- Remote Exercise Prescription, Usual Care
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Heart Failure, Chronic Obstructive Pulmonary Disease
Bisoprolol in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease
The principal research objectives are to demonstrate cardioselective beta-blockade using bisoprolol is not inferior to placebo with regard to pulmonary function and improves quality of life in patients with heart failure and…
- Trial name
- NCT00702156
- Testing
- Bisoprolol
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- NHS Greater Glasgow and Clyde
Rehabilitation, Post-Acute COVID-19 Syndrome
RCT Long COVID-19 Rehabilitation
The Coronavirus 2019 (COVID-19) pandemic has resulted in at least four million infections in Norway. The vast majority of cases are diagnosed and followed up in the community, but some with extensive symptoms and large degree of…
- Conditions
- Rehabilitation, Post-Acute COVID-19 Syndrome, Post-Infectious Disorders
- Trial name
- NCT06085911
- Testing
- One day course, Individual follow-ups
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Migraine
A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches
The purpose of this study is to assess the safety and effectiveness of topiramate as compared to placebo for the prevention of headaches in patients with chronic migraine.
- Trial name
- NCT00210912
- Testing
- topiramate
- Volunteers
- 328 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Mental Illness, Schizophrenia
Cognitive Training to Enhance VA Work Program Outcomes
The purpose of this study is to determine whether augmenting work services with cognitive remediation can improve vocational outcomes for psychiatrically disabled participants in VA work services.
- Conditions
- Mental Illness, Schizophrenia, Depression, PTSD
- Trial name
- NCT00829400
- Testing
- Cognitive Remediation, Nintendo Brain Age
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Connecticut Healthcare System
COPD, Sleep Apnea Syndromes
Registry for Chronic Obstructive Pulmonary Disease With Sleep Apnea Hypopnea Syndrome in China
COPD and sleep apnea dyspnea syndrome represent two of the most common chronic lung diseases. It is reported that the prevalence of COPD with sleep apnea dyspnea syndrome is also very high.
- Trial name
- NCT03182309
- Where
- China
- Volunteers
- 3,502 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Reducing Sedentary Behavior in Patients with Severe COPD: a Feasibility Study on Nurse-Led Motivational Intervention
This feasibility study aims to assess the practicality and acceptability of a nurse-led motivational interview intervention designed to reduce sedentary behavior in patients with severe Chronic Obstructive Pulmonary Disease…
- Trial name
- NCT06882863
- Testing
- Motivational interviewing
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Zealand University Hospital
Chronic Obstructive Pulmonary Disease
Home-based in Chronic Obstructive Pulmonary Disease
Pulmonary rehabilitation consists of a multidisciplinary program of care for patients with chronic respiratory disease, which currently encompasses numerous features and physical training methods aimed at maintaining stability…
- Trial name
- HBCOPD (NCT01554072)
- Testing
- Home based pulmonary rehabilitation with exercise
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho