Clinical trials: Chronic Rhinitis
Rhinosinusitis
Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis
The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS)…
- Trial name
- NCT02038166
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Rhinitis, Urticaria
The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism
Levocetirizine (Xyzal®), the active levorotatory enantiomer of cetirizine (Zyrtec®), is a FDA-approved drug used in the treatment of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic…
- Trial name
- NCT01008592
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University
Chronic Rhinitis
Study on the Optimization of the Diagnostic Process for Chronic Rhinitis Using Nasal Allergen Provocation Test
Chronic rhinitis (CR) is one of the most prevalent global diseases, with studies estimating that up to 30% of the worldwide population is affected.
- Trial name
- NCT06999044
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Rhinosinusitis
The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the…
- Trial name
- NCT01296919
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assuta Hospital Systems
Olfactory Dysfunction
Olfactory Training in Chronic Rhinosinusitis
Persons with a loss of sense of smell, who agree to participate in this study, will be assigned to one of three groups: two groups will have smell training and the third group will not do smell training.
- Trial name
- NCT03055572
- Testing
- Olfactory Training with Essential Oils, Olfactory Training with Pure Fragrance Oils
- Sponsor
- Emory University
Chronic Rhinitis
Posterior Nasal Nerve (PNN) Rhinitis Study
Evaluation of the Aerin Medical Device used for the treatment of chronic rhinitis
- Trial name
- NCT03727347
- Testing
- InSeca Stylus
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aerin Medical
Rhinitis, Urticaria
Safety of Aerius Syrup in Pediatric Patients Aged 1-5 Years Old With Allergic Rhinitis or Chronic Idiopathic Urticaria (Study P04446AM1)(COMPLETED)
The objective of this non-interventional study is to evaluate the safety of Aerius syrup in pediatric patients aged 1-5 years old with allergic rhinitis or chronic idiopathic uticaria.
- Trial name
- NCT00723736
- Testing
- Desloratadine
- Volunteers
- 100 people
- Sponsor
- Organon and Co
Chronic Allergic Rhinitis, Nonallergic Rhinitis
Study to Evaluate the Safety and Tolerability of a Nasal Spray in Patients With Chronic Allergic or Nonallergic Rhinitis
The purpose of this study is to determine if Astepro Nasal Spray (0.1% azelastine hydrochloride) is as safe as Astelin Nasal Spray (0.1% azelastine hydrochloride)
- Trial name
- NCT00783432
- Testing
- Astepro Nasal Spray (0.1% azelastine hydrochloride), Astelin Nasal Spray (0.1% azelastine hydrochloride)
- Where
- United States
- Volunteers
- 862 people
- Sponsor
- Meda Pharmaceuticals
Chronic Rhinitis
Registry of Subject Treated With ClariFix
A multi-center, prospective, non-randomized, observational registry to asses the results of the ClariFix(TM) device when used to ablate unwanted tissue in the nose of subjects with chronic rhinitis.
- Trial name
- SNIF (NCT03739216)
- Testing
- ClariFix
- Where
- 23 sites in United States
- Volunteers
- 354 people
- Sponsor
- Arrinex, Inc.
Chronic Rhinitis
Evaluation of Pulsed Field Ablation of the Posterior Nasal Nerve for Chronic Rhinitis
Evaluation of safety, effectiveness and tolerability of the Aventix Medical Device used for the treatment of chronic rhinitis
- Trial name
- NCT06598319
- Testing
- NOVOCLEAR™ Device
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Aventix Medical Inc.
Nasal Obstruction, Chronic Rhinitis
Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants
This prospective, virtually administered trial conducted throughout the United States aims to evaluate a standardized protocol including the serial dilution of topical decongestants with concurrent topical steroids…
- Trial name
- STEROID (NCT07168148)
- Testing
- Oxymetazoline + Triamcinolone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
Rhinitis, Nasal Polyps
Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction
Nasal symptoms are the main elements that lead to a therapeutic decision and allow for evaluating treatment effects or natural evolution.
- Trial name
- DyNaChron (NCT02879929)
- Volunteers
- 759 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Rhinitis
The Epidemiological and Intrinsic Characteristics of Chronic Rhinitis
Chronic rhinitis affects 10-40% of China's population, or over 300 million people, and can lead to respiratory and psychological issues.
- Trial name
- NCT06370468
- Testing
- Epidemiological investigation
- Where
- China
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Zheng Liu ENT
Rhinitis, Allergic
Mechanism of EGR2 in Allergic Rhinitis
EGR2 may be a target for the treatment of nasal polyps.
- Trial name
- NCT05724290
- Testing
- EGR2
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zu-xia Ma
Rhinosinusitis
Investigate the Role of microRNA in Chronic Rhinosinusitis From DC-Th Axis
This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the…
- Trial name
- ITROMICRFDTA (NCT02325596)
- Testing
- miRNA mimics or inhibitors
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Chronic Sinusitis, Rhinosinusitis
Comparison of Two Steroid Nasal Implants Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis
The purpose of this study is to learn whether there is a difference in postoperative (after surgery) endoscopic appearance of the sinus cavities (the way that the sinuses look through a camera) between sinuses that receive one of…
- Trial name
- NCT03729310
- Testing
- Propel 'implant', Triamcinolone, Nasopore
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Sinusitis
Sinus Balloon Dilation in Pediatric Patients
Safety and effectiveness of sinus balloon dilation in patients 2-21 years old.
- Trial name
- NCT02278484
- Testing
- XprESS device and PathAssist confirmation tools
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Entellus Medical, Inc.
Rhinitis, Allergic, Seasonal, Asthma, Bronchial
An Approved Drug to Study a New Indication for Seasonal Allergic Rhinitis in Patients With Asthma (0476-269)
The purpose of this study is to determine the effect of an approved medication on the symptoms of seasonal allergic rhinitis (a seasonal variety of inflammation of the mucous membrane of the nose) in patients who are experiencing…
- Trial name
- NCT00092885
- Testing
- MK0476, montelukast sodium
- Volunteers
- 831 people
- Sponsor
- Organon and Co
Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
N-acetylcysteine (NAC), known to have mucolytic and antioxidant effects, is widely used to treat respiratory diseases and manage post-surgery pulmonary complications.
- Conditions
- Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis, Chronic Rhinosinusitis
- Trial name
- NOTUS (NCT04131686)
- Where
- South Korea
- Volunteers
- 294 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Chronic Rhinitis
Safety and Efficacy Study of the Neurent Medical NEUROMARK™ System in Subjects With Chronic Rhinitis
A randomized, sham-controlled, double-blind study of the NEUROMARKTM system as a treatment for chronic rhinitis
- Trial name
- MERIDIEN (NCT04769596)
- Testing
- NEUROMARK™ System
- Where
- 8 sites in United States
- Volunteers
- 143 people
- Sponsor
- Neurent Medical