Clinical trials: Chronic Rhinosinusitis
Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps
Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps
Impaired olfaction is one of the major complaints of patients with nasosinus polyposis, with nasal obstruction. In case of failure of medical treatment for patients with polyposis nasosinusal, they may use endoscopic surgery…
- Conditions
- Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps, Olfaction Disorders
- Trial name
- OIPN (NCT04104594)
- Testing
- Sniffin Stick Test, numerical evaluation scale for olfaction, numerical evaluation scale for nasal obstruction
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Olfactory Impairment
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label
Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with…
- Trial name
- SCENT-OL (NCT07689773)
- Testing
- Trigeminal Nerve Stimulation-enhanced Smell Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Chronic Sinusitis
Results of Endoscopic Sinus Surgery in Management of Ophthalmological Complications of Chronic Rhino Sinusitis
Investigate the clinical features of orbital complications of sinusitis in the Egyptian population, and observed that certain ophthalmological manifestations and outcomes were significantly associated with disease stage
- Trial name
- NCT04617223
- Testing
- Endoscopic sinus evacuation
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Chronic Sinusitis, Radiology
Research on Identifying and Treatment Prognosis of Chronic Rhinosinusitis Based on Image and Sequencing Data
This project focuses on researching chronic rhinosinusitis in patients, employing image processing techniques and molecular biology methods to jointly determine the research objectives: 1. Investigating heterogeneity. 2.
- Conditions
- Chronic Sinusitis, Radiology, Pathology, Surgery
- Trial name
- NCT05983003
- Testing
- endoscopic sinus surgery
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Zheng Liu
Chronic Rhinosinusitis With Nasal Polyps
A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Adult Japanese Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps
This is a randomized, multicenter, double-blind, Phase 3 study with 2 parallel groups. The purpose of this study is to evaluate the efficacy, safety, and tolerability of 2 different dosing regimens of itepekimab monotherapy in…
- Trial name
- CEREN-4 (NCT07484230)
- Testing
- Itepekimab (SAR440340)
- Sponsor
- Sanofi
Chronic Rhinosinusitis
Long-term Safety and Efficacy of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps
This is a multicenter, randomized, continuing, Phase II expansion trial to evaluate the safety, efficacy, and immunogenicity of two doses of TQH2722 in the long-term treatment of severe chronic sinusitis with or without nasal…
- Trial name
- NCT06439381
- Testing
- 300mg/600mg of TQH2722 injection
- Where
- 27 sites in China
- Volunteers
- 119 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Sinusitis
480 Biomedical Sinus Drug Depot
This is a Phase I, exploratory safety study of the 480 Biomedical Mometasone Furoate Sinus Drug Depot in adult subjects with chronic sinusitis.
- Trial name
- NCT02967731
- Testing
- 480 Mometasone Furoate Sinus Drug Depot
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 20 people
- Sponsor
- Lyra Therapeutics
Chronic Rhinosinusitis
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network…
- Trial name
- RINET (NCT05935683)
- Testing
- Severe Uncontrolled Chronic Rhinosinusitis patients (CRS)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Italian Academy of Rhinology
Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps
The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear.
- Trial name
- NCT03975842
- Testing
- Sinonasal and otologic evaluation
- Volunteers
- 80 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Chronic Rhinosinusitis, High-risk Patient
Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy
Justification: Chronic rhinosinusitis (CRS) is one of the most common inflammatory diseases with an incidence and prevalence superior to 10%.
- Trial name
- AZI-CRS (NCT02307825)
- Testing
- Azithromycin
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Rhinosinusitis Acute, Rhinosinusitis Chronic
Sinolpan® Pharmacy Non-interventional Study - Quality of Live
This non-interventional study investigates the Quality of Life of patients suffering from rhinosinusitis. Patients who seek advice in a pharmacy and choose to intake Sinolpan® or Sinolpan® forte or to use nasally applied…
- Conditions
- Rhinosinusitis Acute, Rhinosinusitis Chronic, Bronchitis
- Trial name
- NCT04703673
- Testing
- Cineole, Nasal Decongestant
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- Engelhard Arzneimittel GmbH & Co.KG
Post-viral Anosmia, Post-traumatic Anosmia
Self-assessment of Olfactory Disorders for French Speaking Patients
Sense of smell disorders are common and are said to affect up to 20% of the general population. They are often disabling and have a real impact on the quality of life.
- Conditions
- Post-viral Anosmia, Post-traumatic Anosmia, Chronic Rhinosinusitis, Idiopathic Anosmia
- Trial name
- VIF-DOR (NCT04705805)
- Testing
- Self-assessment of olfactory disorders through two questionnaires.
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Rhinosinusitis (Diagnosis)
Real-Life Chronic Rhinosinusitis Outcome Registry
An international consortium of leading medical experts in the field of chronic respiratory disease, the research team of Galenus Health and the non-profit organization EUFOREA (European Forum for Research and Education in Allergy…
- Trial name
- NCT04670172
- Where
- 13 sites in Austria, Belgium and 8 more
- Volunteers
- 4,550 people
- Sponsor
- Change Accelerator in Respiratory Care
Chronic Rhinosinusitis With Nasal Polyps
Dupilumab in Chinese Adult Participants With CRSwNP
This is a parallel group, Phase 3, 2-arm study for treatment. The purpose of this study is to evaluate dupilumab subcutaneous (SC) injections compared to placebo in Chinese adult participants with CRSwNP, on a background therapy…
- Trial name
- NCT05878093
- Testing
- Dupilumab, Budesonide
- Where
- 18 sites in China
- Volunteers
- 63 people
- Sponsor
- Sanofi
Chronic Rhinosinusitis With Nasal Polyps
The Study of CM310 in Patients With Chronic Rhinosinusitis With Nasal Polyps
This is an open-label, single-arm, multicenter, extension study to evaluate the long-term safety and efficacy of CM310 in patients with CRSwNP.
- Trial name
- NCT05131464
- Testing
- CM310
- Where
- 3 sites in China
- Volunteers
- 46 people
- Sponsor
- Keymed Biosciences Co.Ltd
Chronic Sinusitis
Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis
We propose to study the effects of Xolair on patients with chronic sinusitis with or without nasal polyps. Because of the similarities between the inflammatory processes found in asthmas and rhinitis to those found in chronic…
- Trial name
- NCT00603785
- Testing
- Xolair
- Sponsor
- University of California, San Francisco
Chronic Sinusitis, Frontal Sinusitis
Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure
We propose a randomized, single-blinded, prospective trial in order to evaluate the efficacy of the Cook Biodesign ENT Repair graft in improving outcomes after the Draf III or Endoscopic Modified Lothrop procedure.
- Trial name
- NCT02981017
- Testing
- Porcine Intestinal submucosal xenograft
- Where
- United States
- Sponsor
- University of California, Los Angeles
Sinusitis
Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis
This post-market study aims to compare health outcomes for Chronic Rhinosinusitis (CRS) patients treated with balloon sinus dilation (BSD) versus continued medical management.
- Trial name
- MERLOT (NCT01685229)
- Testing
- Balloon sinus dilation, Medical Management
- Where
- 20 sites in United States
- Volunteers
- 198 people
- Sponsor
- Integra LifeSciences Corporation
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP
This study compares two surgical approaches combined with anti-IL-5 therapy in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
- Trial name
- NCT07200336
- Testing
- Mepolizumab, Simple Polypectomy, Extended Endoscopic Sinus Surgery
- Where
- 17 sites in China
- Volunteers
- 360 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Asthma Bronchiale, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Effect of Tezepelumab on Barrier Function in Severe Asthmatic Patients With and Without Comorbid Chronic Rhinosinusitis With Nasal Polyps
In this study, we will investigate the effect of tezepelumab on the epithelial barrier function of the upper and lower airways in patients suffering from severe asthma with and without chronic rhinosinusitis with nasal polyps.
- Trial name
- Tezebarrier (NCT07046117)
- Testing
- Tezepelumab
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna