Clinical trials: Chronic Sinus Disease
End Stage Renal Disease (ESRD), Vascular Access Complication
Autologous Adipose Derived Mesenchymal Stem Cells (AMSC) in Reducing Hemodialysis Arteriovenous Fistula Failure
The aim of this phase 1 study is to determine the role of autologous adipose derived mesenchymal stem cells in the reduction of hemodialysis arteriovenous fistula failure when applied during the time of surgical creation.
- Trial name
- NCT02808208
- Testing
- Single Application of Adipose Derived Mesenchymal Stem Cells (AMSC), Two Applications of Adipose Derived Mesenchymal Stem Cells (AMSC)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Mayo Clinic
End Stage Renal Disease (ESRD), Chronic Kidney Disease Requiring Hemodialysis
Ultrasound Prediction of Successful Balloon Assisted AVF Maturation
An arteriovenous fistula (AVF) is created to allow for cleaning of the blood in patients with severe kidney disease. An artery and a vein are surgically connected, typically in the arm.
- Trial name
- NCT06771973
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
End Stage Renal Disease
Confirmatory Study to Assess the V Needle in End-Stage Renal Disease Patients During In-Clinic Hemodialysis
This study is a prospective, multi-center, single-arm study with subjects acting as their own control designed to confirm the safety, performance, and usability of the V Needle, a new safety needle for use during in-clinic…
- Trial name
- Clinic-SAVER (NCT05493423)
- Testing
- V Needle AV Fistula Set
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Hemotek Medical Inc
Rhinosinusitis
Ideal Frequency of Postoperative High Volume Saline Irrigations Following Endoscopic Sinus Surgery
The aim of this study is to determine what the ideal frequency of high-volume sinonasal saline irrigation in the early postoperative period following ESS for medically refractory CRS.
- Trial name
- NCT01680705
- Testing
- High Volume Saline Irrigation
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Dr. Luke Rudmik
End-stage Renal Disease, Hemodialysis Access Failure
Arteriovenous Fistula Maturation Evaluation Study. FAME Study
Study of the features of hemodynamic and clinical maturation of the native arteriovenous fistula for hemodialysis.
- Conditions
- End-stage Renal Disease, Hemodialysis Access Failure, Vascular Access Maturation, Native Arteriovenous Fistula
- Trial name
- NCT04736875
- Testing
- Doppler ultrasound study
- Where
- Greece
- Volunteers
- 86 people
- Sponsor
- Medifil AE
Chronic Rhinosinusitis (Diagnosis)
Effect of Patient Education Videos on Perioperative Anxiety in Patients Undergoing Endoscopic Sinus Surgery
Chronic rhinosinusitis treatment consists of medical management and surgical intervention. Improving patient education can positively impact perioperative patient experiential outcomes such as anxiety, pain and satisfaction.
- Trial name
- NCT04595461
- Testing
- Video Education, Control
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Haemodialysis
Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis
The primary objective of this study is to evaluate the effect of topically applied heparin in comparison to placebo on suitability of newly constructed primary arteriovenous fistulas in patients planned for haemodialysis at 7th…
- Trial name
- NCT01382888
- Testing
- Heparin 2,400 IU /ml Cutaneous Spray
- Where
- 3 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Cyathus Exquirere Pharmaforschungsgmbh
Chronic Rhinosinusitis
Response Shift in Sinus Surgery Outcomes
The aims of the study are: 1)to assess pre and post-operative Quality of Life (QOL) as measured by the Sino-Nasal Outcomes Test(SNOT)-20 questionnaire and 2)determine the significance of response shift on treatment effect.
- Trial name
- NCT01391910
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Greg Davis
Cancer
Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment
RATIONALE: Caspofungin acetate or amphotericin B liposomal may be effective in preventing or controlling fever and neutropenia caused by chemotherapy, bone marrow transplantation, or peripheral stem cell transplantation.
- Trial name
- NCT00008359
- Testing
- caspofungin acetate, liposomal amphotericin B
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Rhinosinusitis (Diagnosis)
Adrenaline Solution Irrigation and Bleeding During Sinus Surgery
Intranasal irrigation with normal saline is routinely used in sinus surgery to clean the tip of the nasal endoscope and clear the surgical field from blood.
- Trial name
- NCT04551703
- Testing
- Adrenaline saline irrigation
- Volunteers
- 60 people
- Sponsor
- Jordan University of Science and Technology
Chronic Stable Heart Failure
Matrix Metalloproteinase (MMP) in Heart Failure
The purpose of this study is to evaluate the production of MMP in failing hearts.
- Trial name
- NCT00663494
- Volunteers
- 22 people
- Sponsor
- Tottori University Hospital
Chronic Kidney Disease
Impact of Presurgical Exercise on Hemodialysis Fistula Outcomes
The purpose of this research study is to determine whether two different types of forearm exercise, performed before fistula creation surgery, can improve surgery success and fistula maturation.
- Trial name
- NCT02205944
- Testing
- Progressive Handgrip Exercise
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Chronic Sinusitis, Nasal Polyposis
FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps
Chronic rhinosinusitis with nasal polyps is a condition that causes long-lasting inflammation and swelling in the nose and sinuses and may lead to nasal blockage, nasal discharge, facial pressure, and reduced sense of smell.
- Trial name
- NCT07855315
- Testing
- Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery
- Volunteers
- 174 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Chronic Rhinosinusitis (Diagnosis)
Comparative Analysis of Silastic Stenting in Sinus Surgery
Silastic stenting is a measure taken to support tissue healing following sinus surgery. Silastic stents are inserted into the sinus cavities and provide structural support while facilitating healing in the critical period of…
- Trial name
- NCT06502197
- Testing
- Silastic Stenting
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Stenosis, Restenosis
Clinical Study of the BARD® COVERA™ Arteriovenous (AV) Stent Graft
The objective of this study is to assess the safety and effectiveness of the COVERA™ Vascular Covered Stent for the treatment of stenotic lesions in the upper extremity venous outflow of the Arteriovenous (AV) access circuit.
- Trial name
- AVeNEW (NCT02649946)
- Testing
- Covera Vascular Covered Stent following PTA, Percutaneous Transluminal Angioplasty (PTA) with Uncoated PTA Balloon
- Where
- 24 sites in United States, Australia and 6 more
- Volunteers
- 280 people
- Sponsor
- C. R. Bard
Chronic Sinusitis, Endoscopic Sinus Surgery
The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps
Functional endoscopic sinus surgery (FESS) is the pimary surgical treatment of CRS, characterized with the preservation of nasal structure and function.But the control of disease by surgery has been unsatisfactory.
- Conditions
- Chronic Sinusitis, Endoscopic Sinus Surgery, Nasal Polyps
- Trial name
- EMRESSECRS (NCT04852562)
- Testing
- Modified radical endoscopic sinus surgery, functional endoscopic sinus surgery
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zheng Liu
Chronic Sinus Disease, Chronic Sinusitis, Ethmoidal
Pre-operative Steroids in CRSsP
Randomized controlled trial to determine the effectiveness of a five-day course of pre-operative oral steroids on decreasing intra-operative blood loss during endoscopic sinus surgery.
- Conditions
- Chronic Sinus Disease, Chronic Sinusitis, Ethmoidal, Chronic Sinusitis, Sphenoidal, Chronic Sinusitis - Maxillary Bilateral
- Trial name
- NCT05095961
- Testing
- Prednisone
- Sponsor
- Loma Linda University
Chatbot-Based Training, Hemodialysis
DialysisBot: AI Chatbot for Hemodialysis Self-Management
End-stage kidney disease requiring hemodialysis is a chronic condition with substantial clinical, functional, and psychosocial burden.
- Conditions
- Chatbot-Based Training, Hemodialysis, Self-management
- Trial name
- NCT07830810
- Testing
- DialysisBot
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Rome Tor Vergata
Chronic Rhinosinusitis (Diagnosis), Surgery
The Effect of Enhanced Recovery After Surgery in Endoscopic Sinus Surgery
Enhanced recovery after surgery (ERAS) protocols have been widely applied during perioperative periods for different diseases, there are few reports of ERAS in patients undergoing endoscopic sinus surgery (ESS).
- Trial name
- NCT04048070
- Testing
- Flurbiprofen Axetil, Sufentanil, Extended perioperative counseling
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Beijing Tongren Hospital
Sinusitis, Bronchitis, Chronic
Outcomes of Patients Not Responding to Antibiotics in the Community
A study to report the outcomes of patients who fail to respond to beta-lactam and macrolide antibiotics in the community
- Conditions
- Sinusitis, Bronchitis, Chronic, Pneumonia, Bacterial
- Trial name
- NCT00245427
- Testing
- all macrolide antibiotics, all beta-lactam antibiotics
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- CPL Associates