Clinical trials: Chronic Sinus Disease
Sinusitis, Chronic
Nasal and Peripheral Blood Biomarkers of CRS Patients Before and After Surgical Intervention
To characterize inflammatory cells in the nose of patients with Chronic Rhinosinusitis (CRS) before and after sinus surgery.
- Trial name
- NCT03250429
- Testing
- Sinus surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Sinusitis, Nasal Polyps
The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis
Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery.
- Trial name
- NCT03374124
- Testing
- sinonasal outcome test-22
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jianbo Shi
Uremia; Chronic
The Effect of LIPUS on the Maturation of Newly Constructed Autogenous AVF
This study aims to evaluate the effect of 12 week low-intensity pulse ultrasound (LIPUS) intervention on the maturation of newly constructed autologous arteriovenous fistulas in uremic patients.
- Trial name
- NCT06249373
- Testing
- Low intensity pulse ultrasound （LIPUS） intervention for arteriovenous fistula anastomosis
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Suzhou Municipal Hospital
Chronic Renal Failure
A Study of Cytokine and Inflammatory Markers in Patients With Chronic Renal Failure
We hope to study components within the blood that may predict success, failure or other associated complications in relation to the type of vascular access being used.
- Trial name
- NCT00565994
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Arteriovenous Fistula
Neuromuscular Electrostimulation in Radiocephalic Fistula
Objective: To analyze the effect of neuromuscular electrostimulation in the maturation of radiocephalic arteriovenous fistula (RC-AVF) patients with chronic kidney disease (CKD) stage 5-5D Design: Clinical Trial with medical…
- Trial name
- NMS (NCT02925845)
- Testing
- Neuromuscular electrostimulation
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Hospital de Terrassa
Renal Insufficiency, Chronic
VasQ and Hemodynamic Conditions in AVFs
End-stage renal disease (ESRD) is a growing global health problem, strictly connected with progressive ageing population and longer survival of patients living on renal replacement therapy.
- Trial name
- RESHAPE (NCT04141852)
- Testing
- Implantation of VasQ device
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Chronic Kidney Diseases
Effects of Aerobic Exercise on Arteriovenous Fistula
Arteriovenous fistula (AVF) is considered the gold standard for safe and effective vascular access during hemodialytic treatment.
- Trial name
- NCT04015674
- Testing
- Exercise group, Control group
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Rhinosinusitis
Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study
Chronic rhinosinusitis is a pervasive and costly disease. Recent estimates describe over 20 million Americans suffering from this diagnosis at a cost of over $4.3 billion per year.
- Trial name
- NCT00669799
- Testing
- gentamyacin
- Where
- United States
- Sponsor
- University of South Florida
End-Stage Kidney Disease, Hemodialysis Complication
The Arteriovenous Vascular (AV) ACCESS Trial
This study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions
- Trial name
- NCT04646226
- Testing
- AV graft, surgical intervention for creation of a fistula
- Where
- 7 sites in United States
- Volunteers
- 103 people
- Sponsor
- Wake Forest University Health Sciences
End Stage Renal Disease, Hemodialysis Vascular Access Failure
Reduction of Plasma Free VEGF-A Using Low-dose Bevacizumab in Hemodialysis Patients
The primary purpose of this pilot study is to assess the pharmacokinetic profile of low-dose bevacizumab and its effectiveness in reducing plasma free VEGF-A levels safely in hemodialysis patients.
- Trial name
- NCT02695641
- Testing
- 1.25mg bevacizumab, 2.50mg bevacizumab
- Sponsor
- Mayo Clinic
Cystic Fibrosis, Rhinosinusitis
Sino-nasal Inhalation of Sodium Chloride 6,0% in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are almost regularly associated to Cystic Fibrosis (CF). The basic defect in CF is a dysfunction of chloride channels in exocrine glands which equally concerns upper airway mucosa.
- Trial name
- NCT01086839
- Testing
- sodium chloride 6%, sodium chloride 0,9%
- Where
- 11 sites in Germany
- Volunteers
- 69 people
- Sponsor
- University of Jena
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps
This is a single-center, randomized, double-blinded, placebo-controlled clinical trial in adults with moderate-to-severe chronic rhinosinusitis with nasal polyps (CRSwNP) who have no previous nasal surgery.
- Trial name
- NCT07616609
- Testing
- Stapokibart
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tongren Hospital
End-stage Renal Disease
Evaluation of the Radial Artery Deviation And Reimplantation Technique for Primary Hemodialysis Access Creation
The Radial Artery Deviation And Reimplantation (RADAR) technique is a new approach for the construction of hemodialysis arteriovenous fistula.
- Trial name
- RADAR (NCT02728817)
- Testing
- End-cephalic vein to side-radial artery fistula creation, RADAR fistula creation
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sinusitis
Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitis
Chronic rhinosinusitis that recurs after adequate surgery and conventional medical treatment is called refractory chronic rhinosinusitis (RCRS).
- Trial name
- NCT05390255
- Testing
- Mometasone furoate nasal spray hormone, Mometasone furoate nasal spray hormone + oral hormone, Mometasone furoate nasal spray hormone + omalizumab
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Beijing Tongren Hospital
Cancer
Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer
RATIONALE: Suberoylanilide hydroxamic acid may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth.
- Trial name
- NCT00045006
- Testing
- vorinostat
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Kidney Diseases
The Effect of Virtual Reality Application on Pain Due to Fistula Puncture in Hemodialysis Patients
The aim of this study is to examine the effect of virtual reality application on fistula puncture-related pain (FPi-A) in hemodialysis patients.
- Trial name
- NCT05807906
- Testing
- virtual reality application
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Hacettepe University
Arteriovenous Fistula Complications and Failure
Clipped Versus Handsewn Arteriovenous Fistula Anastomosis
The purpose of this study is to determine whether handsewn anastomosis versus clipped technique is associated with more complications, fistula failures, surgical cost and surgical time.
- Trial name
- NCT01669850
- Testing
- Clipped anastomosis, Handsewn anastomosis
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Gundersen Lutheran Medical Foundation
End Stage Renal Failure
Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block
To compare the analgesic properties of ultrasound guided supraclavicular block using ropivacaine 0.5% in arteriovenous fistula creation when used in combination with intravenous administered dexamethasone at 4mg and 8 mg as an…
- Trial name
- NCT06389617
- Testing
- supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous administered dexamethasone
- Volunteers
- 50 people
- Sponsor
- Hospital Universiti Sains Malaysia
Sinusitis, Cystic Fibrosis
Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis
Chronic sinusitis is a frequent complication in cystic fibrosis. The aim of this study is to determine whether Pulmozyme(dornase alfa) would maintain sinus health (compared to placebo) in patients with cystic fibrosis who have…
- Trial name
- NCT00416182
- Testing
- Pulmozyme (dornase alfa)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Vermont
Cystic Fibrosis, Rhinosinusitis
Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients
Patients with cystic fibrosis frequently develop chronic rhinosinusitis. Bacterial colonization is facilitated by a reduced mucociliary function and some previous studies suggest that the microbiology of the upper airways might…
- Conditions
- Cystic Fibrosis, Rhinosinusitis, Lung Diseases
- Trial name
- AVASMUC (NCT02888730)
- Testing
- Tobramycin nebulized nasally, Physiologic serum nebulized nasally
- Where
- 6 sites in France
- Volunteers
- 86 people
- Sponsor
- Virginie ESCABASSE