Clinical trials: Chronic Sinus Infection
Sinusitis
Effect of Reslizumab in Chronic Rhinosinusitis
The purpose of this study is to determine whether Reslizumab is effective for the treatment of chronic sinusitis.
- Trial name
- NCT02799446
- Testing
- Reslizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua S. Jacobs
Chronic Rhinosinusitis
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network…
- Trial name
- RINET (NCT05935683)
- Testing
- Severe Uncontrolled Chronic Rhinosinusitis patients (CRS)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Italian Academy of Rhinology
Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis)
XprESS Maxillary Balloon Dilation Study
A prospective, single-arm, post approval pilot study.
- Trial name
- NCT01525862
- Testing
- Balloon sinus dilation
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Entellus Medical, Inc.
Sinusitis, Chronic
Effect of Postoperative Additive Systemic Steroids in CRSwNP
This study investigate the additive effect of systemic postoperative steroids in patients with chronic rhinosinusitis (CRSwNP). All patients receive a functional endoscopic sinus surgery (FESS) followed by topical steroid spray…
- Trial name
- NCT04915456
- Testing
- Systemic Steroid (Prednisolone)
- Volunteers
- 106 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Breast Cancer, Chronic Myeloproliferative Disorders
Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation
RATIONALE: White blood cells from donors may be able to kill cancer cells in patients with cancer that has recurred following bone marrow or peripheral stem cell transplantation.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003887
- Testing
- peripheral blood lymphocyte therapy
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Nasal Polyps, Chronic Sinusitis
Wound Healing After Endoscopic Sinus Surgery
This study aims to determine the effect of Thymoquinone (0.5%) and olive oil ointment on Wound healing after Endoscopic sinus surgery.
- Trial name
- NCT06070311
- Testing
- Thymoquinone (0.5%) and Olive oil ointment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Maxillary Sinusitis
Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis
This study is intended to evaluate the efficiency of utilizing "dynamic implant valve approach" (DIVA) system in treating chronic maxillary sinusitis.
- Trial name
- NCT03083392
- Testing
- treatment of chronic maxillary sinusitis using DIVA system, "dynamic implant valve approach" - DIVA system
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Western Galilee Hospital-Nahariya
Sinusitis
Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis
This post-market study aims to compare health outcomes for Chronic Rhinosinusitis (CRS) patients treated with balloon sinus dilation (BSD) versus continued medical management.
- Trial name
- MERLOT (NCT01685229)
- Testing
- Balloon sinus dilation, Medical Management
- Where
- 20 sites in United States
- Volunteers
- 198 people
- Sponsor
- Integra LifeSciences Corporation
Sick Sinus Syndrome, Complete Heart Block
Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
The number of cardiac implantable electronic devices (CIEDs) implanted each year has grown rapidly over the past two decades. CIED infections, defined as infections involving the generator implant site (pocket) and/or…
- Conditions
- Sick Sinus Syndrome, Complete Heart Block, Syncope, Chronic Systolic Heart Failure
- Trial name
- ENVELOPE (NCT02809131)
- Testing
- polymixin/bacitracin, cephalexin, or levofloxacin, or clindamycin, Saline
- Where
- United States
- Volunteers
- 1,010 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Rhinosinusitis, Nasal Polyps
Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
This is a randomized, double blind, placebo controlled, parallel group, study in patients with chronic rhinosinusitis with or without nasal polyps.
- Trial name
- DOXYPOSTOP (NCT01198912)
- Testing
- doxycycline 100 mg
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Chronic Sinusitis
The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
Sinus surgery is a common, day surgery procedure performed by general and subspecialty trained otolaryngologists. In most cases, this is a safe surgery with a low incidence of complications.
- Trial name
- NCT00671281
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Chronic Sinusitis
Amphotericin B Suspension in Refractory Chronic Sinusitis
The primary objective of the study is to evaluate the safety and efficacy of Amphotericin B suspension versus placebo in the complete resolution of key chronic sinusitis symptoms during 16 weeks of treatment in patients with…
- Trial name
- NCT00425620
- Testing
- SinuNase
- Where
- 68 sites in United States
- Volunteers
- 300 people
- Sponsor
- Accentia Biopharmaceuticals
Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
N-acetylcysteine (NAC), known to have mucolytic and antioxidant effects, is widely used to treat respiratory diseases and manage post-surgery pulmonary complications.
- Conditions
- Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis, Chronic Rhinosinusitis
- Trial name
- NOTUS (NCT04131686)
- Where
- South Korea
- Volunteers
- 294 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Bladder Cancer, Breast Cancer
Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
RATIONALE: Physician-initiated smoking cessation strategies may be effective in getting early-stage cancer patients to quit smoking.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00002520
- Testing
- nicotine, Usual Care
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Eastern Cooperative Oncology Group
Cystic Fibrosis, Rhinosinusitis
Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are often associated with Cystic Fibrosis. They can restrict quality of life enormously and give cause to repeated ENT surgery.
- Trial name
- NCT00534079
- Testing
- Dornase alfa (Pulmozyme), isotonic saline
- Where
- 2 sites in Germany
- Volunteers
- 23 people
- Sponsor
- University of Jena
Rhinosinusitis
Investigate the Role of microRNA in Chronic Rhinosinusitis From DC-Th Axis
This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the…
- Trial name
- ITROMICRFDTA (NCT02325596)
- Testing
- miRNA mimics or inhibitors
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Hidradenitis Suppurativa
Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa
This study will investigate how well adalimumab works in people with hidradenitis suppurativa (HS) in the short and long term.
- Trial name
- NCT00918255
- Testing
- adalimumab
- Where
- 26 sites in United States, Denmark and 2 more
- Volunteers
- 154 people
- Sponsor
- Abbott
Rhinosinusitis
Allele-specific Expression of a Bitter Taste Receptor
This single-site, within-subject experimental basic research study is designed to analyze the hypothesis that allele-specific expression of the bitter taste receptor T2R38 in taste tissue of individuals heterozygous for the taste…
- Trial name
- NCT02766959
- Testing
- Observational study
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Chronic Sinusitis, Ethmoidal
Quantification of the Airflow Into Sinuses Before and After ArchSinus Implantation
This is a single-center, single-arm, interventional case study designed to compare the sinonasal airflow and symptomatic status of four (4) chronic sinusitis patients, before and after the ArchSinus stent implantation.
- Trial name
- NCT05863468
- Testing
- ArchSinus implantation
- Volunteers
- 4 people
- Sponsor
- STS Medical