Clinical trials: Chronic Sinus Infection, active
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Clinical Trial of TQC2731 Injection in Patients With Chronic Sinusitis and Nasal Polyps
TQC2731 injection is a humanized monoclonal antibody that targets Thymic Stromal Lymphopoietin (TSLP), blocks the TSLP pathway, and inhibits the production of downstream cytokines, thereby exerting anti-inflammatory effects.
- Trial name
- NCT07107256
- Testing
- TQC2731 injection
- Where
- 60 sites in China
- Volunteers
- 246 people
- Sponsor
- Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
Chronic Sinusitis
Endotypic Stability in CRS
A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and…
- Trial name
- NCT06272123
- Testing
- no intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Maxillary Sinusitis, Sinusitis, Chronic
Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis.
This study is a prospective, randomized, placebo-controlled, double-blinded clinical study. The balloon sinuplasty treatment is compared to placebo effect in chronic or recurrent maxillary sinusitis.
- Conditions
- Maxillary Sinusitis, Sinusitis, Chronic, Sinusitis Recurrent, Eustachian Tube Dysfunction
- Trial name
- NCT04645511
- Testing
- Balloon sinuplasty of maxillary sinuses
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Tampere University Hospital
Nasal Polyps, Sinusitis
Dupixent Study for Alternate Administration
Investigators will investigate an alternate Dupilumab administration schedule in patients with recurrent chronic rhinosinusitis with nasal polyposis, who have a history of full endoscopic sinus surgery and are on appropriate…
- Conditions
- Nasal Polyps, Sinusitis, Chronic Disease
- Trial name
- NCT06750471
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Chronic Rhinosinusitis (Diagnosis)
Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior…
- Trial name
- NCT05427695
- Testing
- Lactobacillus sakei proBio65, Isotonic Saline Solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Sinusitis, Chronic, Sinus Disease
Microbiota Transfer for Chronic Rhinosinusitis
Chronic sinusitis (CRS) is a common inflammatory condition of the sinuses that affects up to 2.5% of the Canadian population, and is thought to be caused by bacterial infection, resistant biofilms, chronic inflammation and…
- Conditions
- Sinusitis, Chronic, Sinus Disease, Sinus Infection, Sinus Infection Chronic
- Trial name
- SNMT (NCT05454072)
- Testing
- Sinonasal Microbiota Transfer
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Amin Javer
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Chronic Sinusitis Without Nasal Polyps
A Study to Evaluate the Efficacy and Safety of HTMC0658 Tablets in the Treatment of Chronic Rhinosinusitis Without Nasal Polyps
The purpose of this clinical trial is to assess the efficacy and safety of HTMC0658 tablets in treating subjects with chronic rhinosinusitis without nasal polyps (CRSsNP).
- Trial name
- NCT07174115
- Testing
- HTMC0658
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis
Dupilumab Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis
The investigators will investigate the efficacy of dupilumab in patients with severe eosinophilic CRSsNP who are resistant to the conventional treatment with intranasal corticosteroids and have significantly extensive disease…
- Trial name
- NCT04430179
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of South Florida
Chronic Sinusitis
A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stapokibart in the Treatment of Type 2 Chronic Rhinosinusitis
Through a prospective study, the efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) in the surgical treatment of patients with type 2 chronic rhinosinusitis was verified.
- Trial name
- NCT07073664
- Testing
- The surgical side of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES), The surgical side of Endoscopic Sinus Surgery (ESS)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Union Hospital
Chronic Sinusitis, Acute Sinusitis
Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis.
- Conditions
- Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis
- Trial name
- BEE-SONIC (NCT07151313)
- Testing
- Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sinai University
Sinusitis, Nasal Polyps
A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps
This study will evaluate the effect and safety of 611 in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
- Trial name
- NCT06639295
- Testing
- 611
- Where
- China
- Volunteers
- 243 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Chronic Rhinosinusitis
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network…
- Trial name
- RINET (NCT05935683)
- Testing
- Severe Uncontrolled Chronic Rhinosinusitis patients (CRS)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Italian Academy of Rhinology
Sinusitis, Chronic, Sinus Infection Chronic
Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults
Purulent Oedematous Sinusitis (POS) is a particular form of chronic rhinosinusitis observed in 2% of the general population. In spite of its heavy impact on the quality of life, There is no established recommendation for the…
- Trial name
- SOPAZITHRO (NCT05157685)
- Testing
- Azithromycin Oral Tablet
- Where
- 13 sites in France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Chronic Rhinosinusitis (CRS), Frontal Sinusitis
Endoscopic Direct "Draf IIa" (Carolyn's Window Approach) Versus Endoscopic Angled "Draf IIa"Approach in Chronic Rhinosinusitis With Frontal Sinus Affection ( A Comparative Study ).
Patients with chronic rhinosinusitis with frontal sinus affection indicated for sinuscopy will be randomly categorized in 2 groups: group A will have endoscopic directDraf IIa frontal sinusotomy and group B will have endoscopic…
- Conditions
- Chronic Rhinosinusitis (CRS), Frontal Sinusitis, Draf I or IIa, Functional Endoscopic Sinus Surgery (FESS)
- Trial name
- NCT06668844
- Testing
- Endoscopic direct Draf IIa, Endoscopic angled Draf IIa
- Volunteers
- 68 people
- Sponsor
- Assiut University
Chronic Sinusitis, Nasal Polyps
Biologics in Chronic Rhinosinusitis With Nasal Polyposis
The prevalence of Chronic Sinusitis with Nasal Polyps (CRSwNP) in the United States is estimated at roughly 4%, which equates to over 13 million Americans.
- Trial name
- CRSwNP (NCT06824649)
- Testing
- Biologic Agents
- Where
- 5 sites in United States
- Volunteers
- 504 people
- Sponsor
- Medical University of South Carolina
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Sinusitis Chronic, Postoperative Care
Effect of Probiotic Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis
Chronic rhinosinusitis is a common chronic disease in otolaryngology, with a prevalence of approximately 20% in Taiwan. Patients often experience symptoms such as nasal congestion, runny nose, postnasal drip, and olfactory…
- Trial name
- probiotic (NCT07865715)
- Testing
- heat-killed probiotic LDL557 (Lactobacillus delbrueckii subsp. lactis LDL557), Normal Saline (NS)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taichung Veterans General Hospital
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Sinus Disease
Peppermint and Decongestant Technique on Chronic Sinusitis
Chronic rhinosinusitis (CRS) is defined as persistent symptomatic inflammation of the nasal and sinus mucosa that lasts more than 3 months.
- Trial name
- peppermint (NCT07866937)
- Testing
- Sinus self-massage and inhalation of steated boiled peppermint
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University