Clinical trials: Chronic Spinal Pain
Chronic Low Back Pain
Investigating the Hypoalgesic Effects of Manipulative Therapy Using Pain Conditioning and Expectations in Low Back Pain
The objective of this study will be to identify whether a conditioning procedure by the surreptitious downgrade of a noxious stimulus intensity associated with induced positive expectations about treatment will result in greater…
- Trial name
- NCT05202704
- Testing
- Procedure/Surgery: Experimental: Hidden conditioning + Positive Expectation, Procedure/Surgery: Active Comparator: Positive Expectation, Procedure/Surgery: Active Comparator: Neutral Expectation
- Where
- Brazil
- Volunteers
- 264 people
- Sponsor
- Universidade Federal de Sao Carlos
Spine, Low Back Pain
Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain
The goal of this randomized cross-over mechanistic trial is to compare pre- and post-level cortisol and oxytocin changes in patients with chronic spine pain who receive either a hand's on (massage) or a hand's off (talk-based)…
- Conditions
- Spine, Low Back Pain, Neck Pain
- Trial name
- COTHA (NCT06987786)
- Testing
- Massage, Talk-based therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Low Back Pain
Effects of Programming Parameters on Back Pain Relief in Subthreshold Spinal Cord Stimulation
The purpose of this study is to investigate the effects of varying programming parameters in subthreshold spinal cord stimulation therapy for pain relief.
- Trial name
- NCT01550562
- Testing
- Boston Scientific Precision Plus spinal cord stimulation therapy
- Where
- Australia
- Volunteers
- 1 people
- Sponsor
- Boston Scientific Corporation
Painful Diabetic Neuropathy
Comparison of 10 kHz SCS Combined With CMM to CMM Alone in the Treatment of Neuropathic Limb Pain
This post-market study is being conducted to document comparative safety, clinical effectiveness, and cost-effectiveness of the addition of HF10™ therapy to CMM compared with CMM alone in subjects with chronic, intractable…
- Trial name
- SENZA-PDN (NCT03228420)
- Testing
- Senza HF10 Therapy, CMM
- Where
- 4 sites in United States
- Volunteers
- 430 people
- Sponsor
- Nevro Corp
Degenerative Spondylolisthesis, Chronic Low Back Pain
Lumbar Stabilization Exercises vs Flexor Exercises in Degenerative Spondylolisthesis
The purpose of this study is to compare the effectiveness of pain control and functional improvement in patients with degenerative spondylolisthesis treated with "lumbar stabilization exercises" vs "flexor exercises (williams…
- Trial name
- NCT02664688
- Testing
- Lumbar stabilization exercises, Flexor exercises
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Chronic Low Back Pain
A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain
To administer the MSDR® (Musculoskeletal Disorder Reporting) instrument to document the musculoskeletal profile of patients with chronic low back pain, a prospective, non-randomized, multicenter treatment trial
- Trial name
- NCT00732394
- Testing
- MSDR
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- MedAppraise, Inc.
Lumbar Disc Herniation, Lumbar Disc Disease
Effects of Kinesio Taping on Pain, Endurance, Proprioception, Mobility and Disability in Lumbar Disc Herniation
In addition to the physical therapy program, taping was applied to 90 patients diagnosed with lumbar disc herniation. 90 patients were randomized into 3 groups.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Chronic Pain
- Trial name
- NCT06777095
- Testing
- Routine Treatment + I Taping, Routine Treatment + Star Taping, Routine Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sevtap Günay
Chronic Pain
A Post Market Study to Assess the Spinal Modulation Neurostimulator System for Chronic Intractable Pain
04-SMI-2012 is post market, observational, questionnaire based study to assess the effectiveness of the commercially available Axium neurostimulator in the management of chronic, intractable pain.
- Trial name
- NCT02335502
- Testing
- Implantation with the commercially available Axium neurostimulator
- Where
- 2 sites in Netherlands
- Volunteers
- 66 people
- Sponsor
- Abbott Medical Devices
Chronic Pain, Intractable Pain
Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR).
- Trial name
- PERSIST (NCT07507422)
- Testing
- Commercially available Inceptiv™ neurostimulation systems
- Where
- 6 sites in United States, France
- Volunteers
- 970 people
- Sponsor
- Medtronic
Failed Back Surgery Syndrome, Limb Ischemia
Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion
This observational multicenter study aims to evaluate the reliability and validity of the e-tool for selecting patients eligible for SCS for chronic pain caused by one of the four etiologies listed above in the experience of…
- Conditions
- Failed Back Surgery Syndrome, Limb Ischemia, Neuropathic Pain, Complex Regional Pain Syndromes
- Trial name
- E-TOOLSCS (NCT06229015)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Osteoporosis, Vertebral Fracture
A Trial of Vertebroplasty for Painful Chronic Osteoporotic Vertebral Fractures (Vertos V)
Background The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy.
- Trial name
- VERTOSV (NCT01963039)
- Testing
- percutaneous vertebroplasty
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Pain, Chronic, Pain, Intractable
APP-based Precise Management System of Chronic Intractable Pain
The goal of this clinical trial is to learn about a new management system in chronic and stubborn pain patients who accept therapy of spinal cord stimulation (SCS).
- Trial name
- PreMaSy (NCT05761392)
- Testing
- Precise management
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Spinal Spondyloarthropathies, Axial Spondyloarthritis
Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain (Study P05320)(COMPLETED)
This is a multi-national, multi-site, observational study to determine which of two strategies, when used by referring physicians is superior in the diagnosis of axial spondyloarthritis (AS) by rheumatologists.
- Trial name
- NCT00726765
- Volunteers
- 1,090 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Pain, Other Functional Disturbances Following Cardiac Surgery
Functional and Anatomical MRI of the Spinal Cord and Peri-spinal Tissues
The current study is an amendment to a previously approved blinded randomized controlled trial (NCT02697812) which examines the rate at which the sternal retraction maneuver is performed during cardiac surgery (standard over 30…
- Trial name
- NCT02925364
- Testing
- magnetic resonance imaging (MRI)
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Dr. Tarit Saha
Low Back Pain
Evaluation of the Effectiveness of Transforaminal Epidural Injections in Lumbar Disc Herniation or Radiculitis
To evaluate differences in outcomes in patients receiving steroids compared to those patients randomized to the local anesthetic group who did not receive steroids.
- Trial name
- NCT01052571
- Testing
- lumbar transforaminal epidural injections
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Pain Management Center of Paducah
Low Back Pain, Neck Pain
Goal Oriented Activity for Latinos With Spine Pain
The primary purpose of the study is to determine the efficacy of a culturally adapted cognitive behavioral based tele-rehabilitation program compared to usual care for Hispanics/Latinos with chronic neck or low back pain.
- Conditions
- Low Back Pain, Neck Pain, Chronic Pain, Chronic Low-back Pain
- Trial name
- GOALS (NCT05005416)
- Testing
- GOALS Intervention, Usual Care Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- San Diego State University
Intervertebral Disc Degeneration, Chronic Low-back Pain
Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD
DREAM is a phase II B efficacy monocentric, prospective, randomized, controlled double blinded trial, comparing intra-discal autologous adult bone marrow mesenchymal stem cells (BM-MSC) therapy and sham treated controls in…
- Trial name
- DREAM (NCT05066334)
- Testing
- Autologous BM-MSC
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Back Pain, Chronic Low Back Pain
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System
The purpose of this investigation is to establish the safety and efficacy of the Biostat System when used for treatment of chronic low back (lumbar) pain due to symptomatic internal disc disruptions (IDD) by comparing safety and…
- Conditions
- Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
- Trial name
- NCT01011816
- Testing
- BIOSTAT BIOLOGX, Saline
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Spinal Restoration, Inc.
Chronic Pain
The Benefits of Massage for Back Pain
This study evaluates the effectiveness of a oriented massage by comparing it with that of a classic symmetrical massage.
- Trial name
- NCT07664969
- Testing
- Massage
- Where
- New Caledonia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cabinet d'ostéopathie Michel Boeuf
Chronic Pain
Safety and Effectiveness of Spinal Cord Stimulation With Automatic Control to Treat Chronic Pain in an Extended Trial
The aims of the study are to compare automatic control of spinal cord stimulation with manual control in patients with chronic pain of the trunk and limbs
- Trial name
- Panorama (NCT02161627)
- Testing
- Saluda Medical External Trial System
- Where
- 10 sites in United States
- Volunteers
- 69 people
- Sponsor
- Saluda Medical Pty Ltd