Clinical trials: Chronic Spinal Pain
Low Back Pain
Non-Specific Chronic Back Pain; Insight From Spatial Aspects of Lumbar Spinal Muscle Activation
There is evidence for altered muscle activity patterns in individuals with non-specific chronic back pain (NSCBP). It is unknown why these alterations in activation pattern occur and how they may be linked to pain experience and…
- Trial name
- NCT01214213
- Where
- Norway
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Spinal Cord Injuries, Amputation, Traumatic
Treatment of Chronic Pain After Spinal Cord Injury (SCI) or Amputation
Pain is a major problem for people after spinal cord injuries and amputations. This is a study to test how pain is affected by adding methadone to a six-week program of weekly physical therapy, relaxation training and counseling.
- Conditions
- Spinal Cord Injuries, Amputation, Traumatic, Pain
- Trial name
- NCT00006448
- Testing
- cognitive therapy, Physical Therapy, Methadone
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Chronic Pain, Musculoskeletal Pain
Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain
Chronic spine pain is one of the most common and conditions in adults over the age of 65. Treatments for pain that are non-pharmacologic (do not use over-the-counter or prescription drugs) are recognized as some of the most…
- Trial name
- GOLDEN (NCT06632535)
- Testing
- Chiropractic care, Group medical visits
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Anklyosing Spondylitis
16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis
This study assessed the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who were tolerant to or had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor
- Trial name
- MEASURE2 (NCT01649375)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 219 people
- Sponsor
- Novartis Pharmaceuticals
Low Back Pain
Weight Bath Traction in Chronic Low Back Pain
It is typical of chronic low back pain that, after the first painful episode, is repeated at 44-78% of patients. For acute lumbar pain, approx. 10-15% of them are converted into chronic.
- Trial name
- NCT03488498
- Testing
- questionnaires
- Where
- Hungary
- Volunteers
- 226 people
- Sponsor
- Polyclinic of the Hospitaller Brothers of St. John of God, Budapest
Chronic Low Back Pain
Stimgenics Open-Label, Post Market Study
The purpose of this investigational study is to study the effects of Stimgenics Spinal Cord Stimulation (SGX-SCS) in subjects with chronic, intractable pain of the trunk with lower limb pain, including unilateral or bilateral…
- Trial name
- SGX-SCS-RCT (NCT03606187)
- Testing
- Stimgenics SCS Programming Approach, Standard SCS Programming Approach
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Stimgenics LLC
Sacroiliac Joint Pain
Peripheral Nerve Stimulation for Treatment of Sacroiliac Joint Pain
Prospective randomized controlled study, primary objective: Pain reduction in patients with chronic Sacroiliac joint pain after therapy either with Peripheral Nerve Stimulation or with best medical treatment.
- Trial name
- SIlencing (NCT05357300)
- Testing
- Peripheral Nerve Stimulation
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- PD Dr. med. Simon Bayerl
Back Pain
Spinal Cord Stimulator Implant Study
This study is for patients who have been approved by their doctors and insurance companies to receive spinal cord stimulator implants.
- Trial name
- SCS (NCT00887419)
- Testing
- Coping Skills Training, Education
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Duke University
Brachial Plexus Injury
Neurostimulation for Treatment of Chronic Upper Limb Pain After Brachial Plexus Injury
The purpose of this study is to see how much pain intensity is affected by high frequency spinal cord stimulation therapy in individuals with serious brachial plexus injury.
- Trial name
- NCT04733599
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chronic Low-Back Pain, Refractory Pain
Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)
The objective of this study is to evaluate the efficacy of BurstDR dorsal column stimulation, compared with conventional medical management, in improving pain and back-related physical function in subjects suffering with chronic…
- Conditions
- Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
- Trial name
- NCT04479787
- Testing
- Spinal Cord Stimulation, Conventional Medical Management
- Where
- 30 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Neck Pain
Pilot Study of Spinal Manipulation for Chronic Neck Pain
This study is designed to determine whether a medicine that can produce temporary amnesia (midazolam) can be used to block the memory of treatment with spinal manipulation.
- Trial name
- NCT00030004
- Testing
- spinal manipulation, midazolam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Low Back Pain
Specific or Non-Specific Manipulation for Patients With Back Pain
We aim to evaluate the long-term effects of 10 sessions of spinal manipulative therapy applied in a vertebral region-specific or region nonspecific level immediately after treatment and 3 and 6 months after randomization.
- Trial name
- NCT02883634
- Testing
- Specific manipulation, Non-specific manipulation
- Where
- Brazil
- Volunteers
- 148 people
- Sponsor
- Universidade Cidade de Sao Paulo
Spondyloarthropathy
Rehabilitative Therapy and Pridinol in Patients With Lumbar Spondylarthrosis and Chronic Low Back Pain
Spondyloarthrosis is a degenerative disease involving the intervertebral disc, vertebral bodies, and adjacent soft tissues. Treatment aims to slow disease progression and manage symptoms through an interdisciplinary approach.It…
- Trial name
- NCT06252064
- Testing
- Rehabilitation + Drug therapy, Rehabilitation, Drug therapy
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- University of Palermo
Spinal Cord Stimulation
New Markers to Assess the Efficacity of Spinal Cord Stimulation for the Treatment of Chronic Lower Limb Pain (MOTIVE)
By combining the usual care of patients eligible for spinal cord stimulation (SME) with measurements of the HRV index (Heart Rate Variability), objective measurements of activity (number of steps, quality of sleep) and…
- Trial name
- NCT04785001
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Chronic Low-back Pain
The METRIC Study Protocol
The goal of this clinical trial is to test the effects of spinal manipulative therapy in individuals with chronic primary low back pain and determine the neurophysiological mechanisms underlying pain relief.
- Trial name
- METRIC (NCT05986370)
- Testing
- lumbar spinal manipulative therapy, full spine spinal manipulative therapy
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Chronic Pain
Improving Spinal Cord Stimulation With ECAPS
The purpose of this study will be to investigate the optimization of spinal cord stimulation with ECAPs in patients with spinal cord implants.
- Trial name
- NCT04938245
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Osteopenia, Kyphosis
Effects of the "Spinomed Active" Orthosis on Chronic Back Pain in Women With Vertebral Fractures.
Osteoporotic vertebral fractures often lead to postural changes, chronic spinal pain conditions and limited functionality. Orthoses that straighten the spine have been shown in studies to have a positive effect on pain, posture…
- Trial name
- NCT04854629
- Testing
- Spinomed active
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pain, Myofacial, Pain, Neck
Does Dry Needling Affect Treatment Outcomes of Interlaminar Epidural Steroid Injection in Cervical Disc Herniation?
Chronic neck pain is among the most frequently seen chronic painful conditions. As an important cause of disability, chronic neck pain is a musculoskeletal disorder that negatively affects quality of life.
- Conditions
- Pain, Myofacial, Pain, Neck, Pain, Chronic
- Trial name
- NCT04914637
- Testing
- Cervical interlaminar epidural steroid injection, Dry needling
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Marmara University
Pain Management, Postoperative Acute Pain
Effect of Sedation After Ultrasound-Guided Spinal Anesthesia on Back Pain
This study will evaluate whether giving sedation before spinal anesthesia, when performed with ultrasound guidance, reduces the risk of developing back pain after surgery.
- Conditions
- Pain Management, Postoperative Acute Pain, Chronic Back Pain
- Trial name
- NCT07198412
- Testing
- Ultrasound-guided spinal anesthesia, Midazolam plus ultrasound-guided spinal anesthesia, Landmark-guided spinal anesthesia
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Benha University