Clinical trials: Chronic Spinal Pain
Spinal Cord Injuries, Physical Inactivity
Effects of Physical-Psychological Integrative Intervention on SCI Patient: a Pilot Randomized Controlled Trial
Spinal cord injury (SCI) is a neurological disorder that leads to "partial or complete loss of people's motor and/ or sensory function below the level of the injury".
- Conditions
- Spinal Cord Injuries, Physical Inactivity, Depression, Chronic Pain
- Trial name
- NCT05535400
- Testing
- Physical-Psychological Integrative Intervention, Brief online didactic education
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- The Hong Kong Polytechnic University
Spinal Cord Stimulation, Deep Brain Stimulation
Implantable Systems Performance Registry
The Implantable Systems Performance Registry (ISPR) was developed to evaluate the long-term reliability and performance of market-released Medtronic Neuromodulation infusion and stimulation products.
- Conditions
- Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
- Trial name
- ISPR (NCT00959296)
- Testing
- Various
- Where
- 50 sites in United States, Austria and 5 more
- Volunteers
- 10,981 people
- Sponsor
- MedtronicNeuro
Chronic Pain
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
The REALITY study is a prospective, post-market, non-randomized, multi-center, single-arm, open-label study intended to collect short- and long-term safety and effectiveness data on various populations implanted with Abbott's…
- Trial name
- REALITY (NCT03876054)
- Testing
- Spinal cord stimulation (SCS), Dorsal root ganglion stimulation (DRG)
- Where
- 55 sites in United States, Australia and 7 more
- Volunteers
- 2,000 people
- Sponsor
- Abbott Medical Devices
Chronic Neck Pain
Validation of a Novel Sham Cervical Spinal Manipulation Procedure
Primary hypotheses: Ho1: In chronic neck pain patients, randomly treated with either a "sham" or "real" cervical manipulation procedure, the probability of perceiving a Real Manipulation Procedure is equal to the probability of…
- Trial name
- NCT00978094
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Canadian Memorial Chiropractic College
Chronic Low-back Pain, CRPS
Comparison of Continuous and Burst High Frequency Spinal Cord Stimulation Paradigms
Spinal cord stimulation (SCS) delivered at 10kHz frequency (HF10 Therapy) has demonstrated superiority to traditional SCS for leg and back pain.
- Conditions
- Chronic Low-back Pain, CRPS, Peripheral Neuropathy
- Trial name
- NCT04709757
- Testing
- Intermittent Dosing HF10 30/90, Intermittent Dosing HF10 30/360
- Sponsor
- Rush University Medical Center
Chronic Pain, Intractable Pain
Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR).
- Trial name
- PERSIST (NCT07507422)
- Testing
- Commercially available Inceptiv™ neurostimulation systems
- Where
- 6 sites in United States, France
- Volunteers
- 970 people
- Sponsor
- Medtronic
Low Back Pain, Chronic Low Back Pain
Evaluation of Stabilization Training With Biofeedback in Lumbosacral Spine Pain Syndrome
The aim of the study is to evaluate the effects of biofeedback-assisted stabilization training and conventional therapy on pain perception, balance, spinal mobility, functional performance, physical activity, stress level, and…
- Trial name
- NCT07463729
- Testing
- Standard Rehabilitation, Biofeedback Ultrasonography
- Where
- Poland
- Volunteers
- 110 people
- Sponsor
- University of Rzeszow
Type 2 Diabetes, Neuropathy, Painful
Methylglyoxal Evaluation in Humans
The investigators will test the hypothesis that patients with low back pain associated with lumbar disc aberrancy will have elevated MGO-protein levels circulating in the blood that are comparable to patients with painful…
- Conditions
- Type 2 Diabetes, Neuropathy, Painful, Chronic Low-back Pain, Lumbar Disc Herniation
- Trial name
- MEH (NCT05350553)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Chronic Pain Due to Trauma, Spinal Cord Injuries
The Effect of Gabapentin Used as a Preemptive to the Emergence and Development Chronic Neuropathic Pain in Patients After Spinal Cord Trauma
Study of the effect of gabapentin used as a preemptive to the emergence and development chronic neuropathic pain in patients after spinal cord trauma
- Trial name
- GabaNeuBol (NCT03255330)
- Testing
- Gabapentin, Metamizol, Tramadol
- Where
- Czechia
- Sponsor
- Masaryk University
Low Back Pain, Disc, Herniated
Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation
Lumbar disk herniation (LDH)is a prevalent health problem around the world. It can cause symptoms of low back pain, numbness or weakness.The understanding of low back pain in traditional Chinese medicine(TCM) theory"unbalanced…
- Trial name
- NCT03475095
- Testing
- Tuina
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Chronic Low Back Pain, Spinal Cord Injury
SERENITY Study of Chronic Pain Interference in Adults
SERENITY is a remote observational study designed to characterize inter-individual differences in chronic pain among adults with chronic low back pain and adults with spinal cord injury-related neuropathic pain.
- Conditions
- Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain
- Trial name
- SERENITY (NCT07820475)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Low Back Pain, Mechanical, Spinal Stenosis
Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients
Observational study of axial spine pain and hyperflexibility. Patients will receive physical exam maneuvers (traditional straight leg raise, FABER, facet loading as well as Beighton's hypermobility score) and blood / urine /…
- Conditions
- Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical
- Trial name
- Hypermoble (NCT02761928)
- Testing
- Beighton score for hypermobility
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Pain, Back Pain
Safety and Efficacy Study of the Evoke™ SCS System With Feedback vs. Conventional Stimulation
The purpose of this study is to evaluate the safety and efficacy of the Saluda Medical Evoke SCS System with feedback control to treat chronic pain of the trunk and/or limbs.
- Conditions
- Chronic Pain, Back Pain, Pain
- Trial name
- EVOKE (NCT02924129)
- Testing
- Evoke Spinal Cord Stimulator (SCS) System
- Where
- 16 sites in United States
- Volunteers
- 134 people
- Sponsor
- Saluda Medical Americas, Inc.
Pain, Neuropathic
Comparative Study in Patients With Refractory Chronic Lower Limb Neuropathic Pain and/or Back Neuropathic Pain.
Neuropathic pain is described as a "pain initiated or caused by a primary lesion or dysfunction in the nervous system". It is thus often a chronic affection, as a difficult-to-treat condition.
- Trial name
- BOOST DRG (NCT04852107)
- Testing
- Spinal Cord Stimulation, association of both (DUAL), Dorsal Root Ganglion stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Failed Back Surgery Syndrome, Chronic Pain
Patient Profiling and Outcome Assessment in Spinal Cord Stimulation for Chronic Back and/or Leg Pain
The PROSTIM study is an ongoing prospective, multicentric and observational clinical study. Patients are recruited in three different centers in Eastern Belgium from May 2018 onwards.
- Trial name
- PROSTIM (NCT05349695)
- Testing
- Spinal cord stimulation
- Where
- 3 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Studie- & Opleidingscentrum Neurochirurgie Virga Jesse
Chronic Low Back and Leg Pain
Spinal Cord Stimulation Research Study
The purpose of this study is to characterize a patient's activity levels before and after spinal cord stimulation therapy.
- Trial name
- ADR-SCS (NCT00768872)
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- MedtronicNeuro
Psoriatic Arthritis
Rewiring the Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis
Despite advances in immunomodulatory therapies, many Psoriatic arthritis (PsA) patients experience persistent pain unrelated to clinical active joint inflammation.
- Trial name
- REACT (NCT07403890)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS), Control Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- NHS Greater Glasgow and Clyde
Chronic Pain
Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury
The diagnosis of chronic pain currently lacks objective and quantifiable biomarkers. This study aims to observe the EEG characteristics of patients with chronic pain following spinal cord injury and subsequently administer…
- Trial name
- NCT06531837
- Testing
- Esketamine(Continuous infusion), Remifentanil (Target-Controlled Infusion), Flurbiprofen (Single intravenous injection)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
The study will be investigating the effectiveness of oxycodone-naloxone (brand name Targin®) at treating chronic pain in individuals with spinal cord injury.
- Trial name
- NCT03179475
- Testing
- Oxycodone Naloxone Combination
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Pain, Postoperative, Pain
Improved Rehabilitation After Spinal Surgery in Adolescents
Impact of the OFA technique on postoperative recovery from adolescent spine surgery and the incidence of chronic postoperative pain.
- Conditions
- Pain, Postoperative, Pain, Scoliosis, Spinal Fusion
- Trial name
- NCT04183049
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital